Zejula (Niraparib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Zejula Used For?
Zejula is a medication that contains the active ingredient niraparib, which is used to treat certain types of cancer.
Primary Uses
Zejula is primarily used for treating ovarian cancer, fallopian tube cancer, or peritoneal cancer that has either partially or completely responded to platinum-based chemotherapy.
How It Works
Niraparib works by blocking an enzyme called PARP, which helps cancer cells repair their damaged DNA. By inhibiting this enzyme, the drug prevents the cancer cells from repairing themselves, leading to their death.
Good to know: Zejula is not considered addictive.
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How to Take Zejula
It is important to follow your doctor's instructions when taking Zejula.
Dosage Instructions
The typical starting dose is 2 capsules (200 mg) taken once daily. Depending on your doctor's assessment, a starting dose of 3 capsules (300 mg) may be appropriate. Your doctor may adjust the dose based on side effects or liver function.
What If You Miss a Dose?
If you miss a dose, take your next dose at the scheduled time. Do not take an extra dose to make up for a missed one.
Important: Never double the dose to compensate for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Tiredness
- Weakness
- Nausea
- Stomach pain
- Vomiting
- Constipation
- Diarrhoea
- Indigestion
- Decreased appetite
- Inability to sleep
- Headache
- Dizziness
- Runny or stuffy nose
- Shortness of breath
- Cough
- High blood pressure
- Urinary tract infection
- Heart palpitations
- Back pain
- Joint pain
Seek immediate medical attention if you experience:
- Bruising or prolonged bleeding
- Shortness of breath, extreme tiredness, pale skin, or rapid heartbeat (signs of low red blood cell count)
- Fever or signs of infection (indicating low white blood cell count)
- Kidney problems such as fatigue, nausea, changes in urination, or swelling
- Allergic reactions including difficulty breathing or low blood pressure
Important Warnings
There are several important considerations before using Zejula.
Who Should Not Take Zejula
Do not use Zejula if you are allergic to niraparib or any of its ingredients, are pregnant, intend to become pregnant, or are breastfeeding.
Medical Conditions to Discuss
Inform your doctor if you have low blood counts, high blood pressure, myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), or posterior reversible encephalopathy syndrome (PRES).
Pregnancy and Breastfeeding
Zejula can be harmful to an unborn baby. Women who could become pregnant must use effective contraception during treatment and for 6 months after the last dose. Do not breastfeed while taking Zejula and for at least 1 month after your last dose.
Drug Interactions
Certain medications may interact with Zejula, affecting its effectiveness.
- Cyclosporin
- Tacrolimus
- Alfentanil
- Ergotamine
- Pimozide
- Quetiapine
- Clozapine
- Halofantrine
- Theophylline
- Ropinirole
- Irinotecan
- Rosuvastatin
- Simvastatin
- Atorvastatin
- Methotrexate
- Metformin
Alcohol & Driving
Be cautious when consuming alcohol or operating machinery while on Zejula.
Alcohol
Consult your doctor about alcohol consumption while taking Zejula.
Driving and Operating Machinery
Zejula may cause dizziness or weakness. Avoid driving or operating machinery until you know how it affects you.
Storage
Store Zejula capsules in their original packaging in a cool, dry place below 25°C, out of reach of children.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The time it takes for Zejula to work can vary by individual and should be discussed with your doctor.
You can take Zejula with or without food.
No, Zejula is not considered addictive.
Do not stop taking Zejula suddenly without consulting your doctor, as it may worsen your condition.
Consult your doctor regarding alcohol consumption while on Zejula.
Weight gain is not listed as a common side effect of Zejula.
Elderly patients should discuss their health conditions with their doctor before taking Zejula.
If you miss a dose, take your next dose at the scheduled time and do not double up.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.