Rexulti (Brexpiprazole)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Rexulti Used For?
Rexulti is an antipsychotic medication that helps manage symptoms of schizophrenia and agitation linked to Alzheimer's disease in adults who do not respond to non-drug treatments.
Primary Uses
Rexulti is primarily used to treat adults with schizophrenia and agitation associated with dementia due to Alzheimer's disease.
How It Works
Rexulti acts on certain neurotransmitters in the brain to help control symptoms of schizophrenia and agitation.
Good to know: Rexulti is not considered addictive.
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How to Take Rexulti
Follow your doctor's instructions on how to take Rexulti, as the dosage can vary based on your condition.
Dosage Instructions
Your doctor will determine the appropriate dosage for you. It is important to follow their guidance closely.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember. If it's close to your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Important: Never take a double dose to make up for a missed one, as this could increase the risk of side effects.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- drowsiness
- diarrhea
- indigestion
- weight gain
- shaking
- restlessness
- dizziness
- impulsive behaviors
- sleepwalking
Seek immediate medical attention if you experience:
- serious allergic reactions
- tardive dyskinesia
- neuroleptic malignant syndrome
- suicidal thoughts or actions
- swelling or pain in the leg
- chest pain or difficulty breathing
Impulse Control Issues
Rexulti may lead to impulsive behaviors, including compulsive gambling or spending.
Important Warnings
There are several important warnings to consider before using Rexulti.
Who Should Not Take Rexulti
Do not take Rexulti if you have a known allergy to brexpiprazole or any of its ingredients.
Medical Conditions to Discuss
Inform your doctor if you have conditions such as dementia, neuroleptic malignant syndrome, tardive dyskinesia, heart issues, epilepsy, or a history of suicidal thoughts.
Pregnancy and Breastfeeding
Rexulti is not recommended during pregnancy. If you are pregnant or plan to become pregnant, discuss the risks with your doctor. It is also advised not to breastfeed while taking Rexulti.
Elderly Patients With Dementia: Elderly patients with dementia may be at increased risk for serious side effects, including stroke and heart problems.
Drug Interactions
Certain medications can interact with Rexulti, affecting its effectiveness.
Grapefruit interaction: Avoid grapefruit while taking Rexulti, as it may affect how the medication works.
- medications for depression and anxiety (e.g., fluoxetine, paroxetine)
- anticonvulsants for epilepsy
- medications for high blood pressure
- medications for heart rhythm issues
- medications for blood disorders
Alcohol & Driving
Be cautious with alcohol and driving while taking Rexulti.
Alcohol
Avoid alcohol while taking Rexulti, as it can enhance side effects.
Driving and Operating Machinery
Rexulti may cause dizziness or tiredness. Do not drive or operate heavy machinery until you know how it affects you.
Temperature Regulation
Rexulti can affect your body's ability to regulate temperature. Stay cool in hot weather and warm in cold weather.
Storage
Store Rexulti in its original container in a cool, dry place below 30°C, away from moisture and sunlight. Keep it out of reach of children.
Overdose Information
If you suspect an overdose, contact your doctor or the Poisons Information Centre at 13 11 26 immediately, even if you feel fine. Monitoring may be required.
Frequently Asked Questions
The time it takes for Rexulti to work can vary by individual. It may take several weeks to notice significant improvements.
Yes, Rexulti can be taken with or without food.
No, Rexulti is not considered addictive.
Do not stop taking Rexulti suddenly without consulting your doctor, as it may worsen your condition.
It is advised to avoid alcohol while taking Rexulti due to potential increased side effects.
Weight gain is a possible side effect of Rexulti, and you should monitor your weight regularly.
Elderly patients may be at increased risk for serious side effects, so they should use Rexulti with caution.
If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.