Pulmozyme (Dornase Alfa)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Pulmozyme Used For?
Pulmozyme is a medication used to help manage cystic fibrosis, a genetic condition that leads to the production of thick, sticky mucus in the lungs.
Primary Uses
Pulmozyme is primarily used to treat cystic fibrosis by breaking down DNA in mucus, improving lung function, and reducing infection risk.
How It Works
Dornase alfa, the active ingredient in Pulmozyme, mimics a natural enzyme that breaks down excess DNA in lung secretions, thereby reducing mucus thickness and easing breathing.
Good to know: Pulmozyme is not addictive.
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How to Take Pulmozyme
Pulmozyme is inhaled using a nebuliser as prescribed by your doctor.
Dosage Instructions
The typical dosage is one ampoule inhaled once a day. For some adults over 21, the dose may be increased to twice a day.
What If You Miss a Dose?
If you miss a dose, take your next dose at the scheduled time. Do not double up on doses.
Important: Never double dose to make up for a missed dose.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- hoarse voice
- sore throat
- skin rash
- chest pain
- conjunctivitis
- upset stomach
Seek immediate medical attention if you experience:
- severe allergic reactions
Important Warnings
There are specific warnings to consider before using Pulmozyme.
Who Should Not Take Pulmozyme
Do not use Pulmozyme if you are allergic to dornase alfa or any ingredients in the solution, or if you have had a reaction to Chinese Hamster Ovary (CHO) proteins.
Medical Conditions to Discuss
Consult your doctor if you have other health issues, are under 5 years old, or are taking other medications.
Pregnancy and Breastfeeding
Consult your doctor if you are pregnant or breastfeeding, as it is unknown if Pulmozyme is harmful to an unborn baby or if it passes into breast milk.
Drug Interactions
Inform your doctor about any other medications you are taking.
- antibiotics
- bronchodilators
- vitamins
- corticosteroids
- painkillers
Alcohol & Driving
Be cautious when driving or operating machinery until you know how Pulmozyme affects you.
Alcohol
No specific warnings regarding alcohol were mentioned.
Driving and Operating Machinery
Pulmozyme has not been shown to impair your ability to drive or operate machinery.
Storage
Store Pulmozyme in the fridge (2–8°C) in its protective foil pouches, away from light, heat, and moisture.
Overdose Information
If you think you have inhaled too much Pulmozyme, seek medical attention immediately. Contact your doctor or go to the nearest hospital.
Frequently Asked Questions
Pulmozyme works by breaking down DNA in mucus, which can improve lung function and ease symptoms, but the time to notice effects may vary.
There are no specific instructions regarding food interactions with Pulmozyme.
No, Pulmozyme is not considered addictive.
Do not stop using Pulmozyme suddenly without consulting your doctor, as it may affect your lung function.
There are no specific warnings about alcohol consumption while taking Pulmozyme.
Weight gain is not listed as a side effect of Pulmozyme.
Consult your doctor for advice regarding the safety of Pulmozyme in elderly patients.
If you miss a dose, take your next dose at the scheduled time and do not double up.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.