Prograf and Advagraf XL (Tacrolimus)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Prograf and Advagraf XL Used For?
Prograf and Advagraf XL are medications that contain tacrolimus, which helps prevent your body from rejecting a transplanted organ such as a liver, kidney, lung, or heart.
Primary Uses
Used primarily to prevent organ rejection after transplants.
How It Works
Tacrolimus suppresses the immune system to stop it from attacking the transplanted organ.
Good to know: Prograf and Advagraf XL are not addictive.
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How to Take Prograf and Advagraf XL
It's important to take Prograf and Advagraf XL exactly as prescribed by your doctor.
Dosage Instructions
Prograf should be taken in two doses each day, while Advagraf XL is taken once daily in the morning. Always take the capsules at least 1 hour before or 2 to 3 hours after a meal.
What If You Miss a Dose?
If you miss a dose, skip it and take the next dose at the scheduled time. Do not double the dose.
Important: Never change your dose without consulting your doctor.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- tiredness
- nausea
- vomiting
- loss of appetite
- diarrhea
- headache
- sleeping difficulties
Seek immediate medical attention if you experience:
- allergic reactions (rash, swelling, difficulty breathing)
- fever
- high blood sugar
- unusual bleeding or bruising
- high blood pressure
- palpitations
- new lumps or changes in moles
- yellowing of skin or eyes (jaundice)
- seizures
Important Warnings
There are several important warnings to consider when using Prograf and Advagraf XL.
Who Should Not Take Prograf and Advagraf XL
Do not use if you are allergic to tacrolimus, macrolide antibiotics, or any ingredients in the medication.
Medical Conditions to Discuss
Inform your doctor if you have kidney problems, are receiving cyclosporin therapy, or have other medical conditions.
Pregnancy and Breastfeeding
Consult your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
Drug Interactions
Certain medications can interact with Prograf and Advagraf XL, affecting their effectiveness.
Grapefruit interaction: Avoid grapefruit juice as it can interfere with the action of Prograf and Advagraf XL.
- macrolide antibiotics (e.g., erythromycin, clarithromycin)
- antifungal medications (e.g., ketoconazole, fluconazole)
- HIV protease inhibitors
- HCV protease inhibitors
- mycophenolic acid
- stomach ulcer medications (e.g., omeprazole)
- anti-arrhythmic drugs (e.g., amiodarone)
- statins
- carbamazepine, phenytoin, phenobarbital
- corticosteroids
- herbal preparations (e.g., St. John’s wort)
Alcohol & Driving
Be cautious with alcohol consumption and driving while on Prograf and Advagraf XL.
Alcohol
Discuss alcohol use with your doctor, as it may affect your treatment.
Driving and Operating Machinery
Be careful when driving or using machinery, as these medications may cause visual or nervous disturbances.
Storage
Store Prograf capsules below 30°C and Advagraf XL capsules below 25°C in a cool, dry place. Keep out of reach of children.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The time it takes for Prograf and Advagraf XL to work can vary, but they are intended to prevent organ rejection immediately after a transplant.
It's best to take these medications at least 1 hour before or 2 to 3 hours after a meal.
No, Prograf and Advagraf XL are not addictive.
Do not stop taking these medications without consulting your doctor, as it may lead to organ rejection.
Discuss alcohol consumption with your doctor, as it may affect your treatment.
Weight gain is not specifically mentioned as a side effect, but it is important to monitor your overall health.
Elderly patients should consult their doctor to ensure safety, especially if they have pre-existing conditions.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.