Polivy (Polatuzumab Vedotin)

Complete patient guide for uses, dosage, side effects, and safety information

Prescription Required

Quick Facts

Generic Name

polatuzumab vedotin

Drug Class

anti-neoplastic agent

Used For

treatment of diffuse large B-cell lymphoma

How Taken

administered via intravenous infusion every three weeks

What Is Polivy Used For?

Polivy is a medication that contains polatuzumab vedotin, designed to treat diffuse large B-cell lymphoma, particularly in cases that have not been treated before or have returned after previous therapies.

Primary Uses

It is used for treating diffuse large B-cell lymphoma that has either not been treated previously or has recurred after one or more treatments.

How It Works

Polivy targets cancer cells by delivering the anti-cancer agent vedotin directly to them, inhibiting their growth and spread.

Good to know: Polivy is not considered addictive.

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How to Take Polivy

Polivy is administered by a healthcare professional through an intravenous infusion, ensuring proper dosage and monitoring.

Dosage Instructions

The recommended dosage is based on your weight and is given as an IV infusion once every three weeks. The first infusion lasts 90 minutes, and if tolerated well, subsequent infusions may be shortened to 30 minutes.

What If You Miss a Dose?

If you miss an appointment for your infusion, reschedule as soon as possible. Do not wait for your next planned appointment.

Important: Never double the dose if you miss an appointment.

Available Tablet Strengths

140 mg

140 mg Tablet White to grey, Powder • AUST R 314866

30 mg

30 mg Tablet White to grey, Powder • AUST R 374135

Side Effects

Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.

Common Side Effects

These side effects occur relatively frequently and usually don’t require emergency care:

nausea
vomiting
fatigue
dizziness
rash
decreased appetite

Seek immediate medical attention if you experience:

signs of an allergic reaction (swelling of face, lips, tongue, or throat)
shortness of breath
severe infections
numbness or tingling in hands or feet
confusion or memory loss

Important Warnings

There are several important considerations to keep in mind before using Polivy.

Who Should Not Take Polivy

Do not use Polivy if you have a known allergy to polatuzumab vedotin or any of its ingredients, or if you have an active severe infection.

Medical Conditions to Discuss

Inform your doctor if you have a history of nerve problems, liver issues, or recurrent infections.

Pregnancy and Breastfeeding

Notify your doctor immediately if you become pregnant during treatment. Effective contraception is advised during treatment and for 9 months after stopping. Breastfeeding is not recommended during treatment and for at least 3 months after the last dose.

Drug Interactions

Certain medications may interact with Polivy, affecting its efficacy.

oral antifungal medications (e.g., ketoconazole, itraconazole, voriconazole)
some antibiotics (e.g., rifampicin)

Alcohol & Driving

Caution is advised when driving or operating machinery while taking Polivy, as it may cause light-headedness or dizziness.

Alcohol

Consult your doctor regarding alcohol consumption while on Polivy.

Driving and Operating Machinery

Avoid driving or using machinery if you experience dizziness or fatigue.

Storage

Polivy should be stored in a refrigerator at temperatures between 2°C and 8°C.

Overdose Information

Overdose is unlikely as Polivy is administered under medical supervision. If side effects occur, inform your healthcare provider immediately.

Frequently Asked Questions

The effectiveness of Polivy can vary, and your doctor will monitor your progress during treatment.

Polivy is administered via infusion and does not have dietary restrictions.

No, Polivy is not considered addictive.

Do not stop treatment without consulting your doctor, as this may affect your health.