Pirfenidet (Pirfenidone)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Pirfenidet Used For?
Pirfenidet is a medication that contains the active ingredient Pirfenidone, used primarily to treat Idiopathic Pulmonary Fibrosis (IPF), a condition characterized by lung tissue scarring that impairs breathing.
Primary Uses
Pirfenidet is used to manage Idiopathic Pulmonary Fibrosis (IPF), helping to reduce lung scarring and improve breathing.
How It Works
Pirfenidone works by reducing inflammation and fibrosis in the lungs, thereby improving lung function.
Good to know: Pirfenidet is not considered addictive.
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How to Take Pirfenidet
It is important to follow your doctor's instructions when taking Pirfenidet to ensure effective treatment.
Dosage Instructions
The recommended dosage starts with 267 mg taken three times a day for the first week, increasing to 534 mg three times a day for the second week, and then 801 mg three times a day from day 15 onward.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember, but wait at least 3 hours before taking the next dose. Do not take more than 3 doses in a day.
Important: Never double the dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Tiredness
- Dizziness
- Headache
- Muscle aches
- Nausea
- Diarrhea
- Indigestion
- Loss of appetite
Seek immediate medical attention if you experience:
- Jaundice (yellowing of the skin or eyes)
- Dark or brown urine
- Upper stomach pain
- Easy bruising or bleeding
- Swelling of the face, lips, or tongue
- Difficulty breathing or wheezing
Important Warnings
There are several important considerations to keep in mind before taking Pirfenidet.
Who Should Not Take Pirfenidet
Do not take Pirfenidet if you have a known allergy to Pirfenidone or any of its ingredients, have severe liver or kidney problems, or are taking fluvoxamine.
Medical Conditions to Discuss
Discuss any history of kidney or liver problems with your doctor, as these may affect your treatment.
Pregnancy and Breastfeeding
Do not take Pirfenidet if you are pregnant or breastfeeding, as it may harm your baby.
Drug Interactions
Certain medications may interact with Pirfenidet, affecting its effectiveness.
Grapefruit interaction: Avoid grapefruit juice while taking Pirfenidet, as it may interfere with the medication's effectiveness.
- Fluvoxamine
- Tetracyclines (e.g., doxycycline)
- Ciprofloxacin
- Enoxacin
- Omeprazole
- Rifampicin
- Amiodarone
- Propafenone
Alcohol & Driving
Be cautious with alcohol consumption and operating vehicles while taking Pirfenidet.
Alcohol
Inform your doctor if you consume alcohol, as it may affect your treatment.
Driving and Operating Machinery
Pirfenidet may cause dizziness and tiredness; avoid driving or operating machinery if you experience these symptoms.
Storage
Store Pirfenidet tablets in a cool, dry place below 25 °C, away from moisture and heat.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The effects of Pirfenidet may vary, but it is important to continue taking it as prescribed for the best results.
Yes, take Pirfenidet with or immediately after food to reduce the risk of side effects.
No, Pirfenidet is not considered addictive.
Do not stop taking Pirfenidet suddenly without consulting your doctor, as your condition may worsen.
Inform your doctor if you consume alcohol, as it may affect your treatment.
Weight loss can occur while taking Pirfenidet, and your doctor will monitor your weight during treatment.
Discuss any concerns about safety in elderly patients with your doctor.
If you miss a dose, take it as soon as you remember, but separate doses by at least 3 hours.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.