Otezla (apremilast) (Apremilast)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Otezla (apremilast) Used For?
Otezla is a medication that helps reduce inflammation in the body. It is prescribed for adults to manage specific inflammatory conditions.
Primary Uses
Otezla is used to treat plaque psoriasis, psoriatic arthritis, and mouth ulcers related to Behçet's disease.
How It Works
Otezla works by inhibiting the activity of phosphodiesterase 4, which helps regulate the immune response associated with these conditions.
Good to know: Otezla is not considered addictive.
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How to Take Otezla (apremilast)
Otezla is taken as a tablet, which can be swallowed whole with water, either with or without food.
Dosage Instructions
The initial treatment starts with a titration phase, where the dose gradually increases over the first 6 days. The recommended dose after this phase is 30 mg taken twice daily.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember. If it's close to your next dose, skip the missed dose and continue with your schedule. Do not double up.
Important: Never take a double dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- diarrhoea
- nausea
- vomiting
- stomach pain
- indigestion
- decreased appetite
- cough
- cold
- runny nose
- fatigue
- difficulty sleeping
- headaches
- back pain
Seek immediate medical attention if you experience:
- shortness of breath
- wheezing
- swelling of the face, lips, or tongue
Important Warnings
There are specific warnings to consider before taking Otezla.
Who Should Not Take Otezla (apremilast)
Do not take Otezla if you are allergic to apremilast or any of its ingredients, or if you are pregnant or breastfeeding.
Medical Conditions to Discuss
Discuss with your doctor if you have kidney problems, a history of depression, or if you are taking other medications.
Pregnancy and Breastfeeding
Otezla should not be taken during pregnancy or while breastfeeding.
Drug Interactions
Certain medications may interact with Otezla and affect its effectiveness.
- rifampicin
- carbamazepine
- phenytoin
- phenobarbitone
- St. John's Wort
Alcohol & Driving
Be cautious when driving or operating machinery until you know how Otezla affects you.
Alcohol
Consult your doctor before consuming alcohol while on Otezla.
Driving and Operating Machinery
Use caution when driving or using tools until you are aware of how Otezla affects your abilities.
Storage
Store Otezla below 30°C in a cool, dry place away from children.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact the Poisons Information Centre at 13 11 26 or go to the nearest hospital.
Frequently Asked Questions
The time it takes for Otezla to show effects can vary, but many patients notice improvements within a few weeks.
Yes, Otezla can be taken with or without food.
No, Otezla is not considered addictive.
Do not stop taking Otezla without consulting your doctor, as it may affect your condition.
Consult your doctor before consuming alcohol while on Otezla.
Weight changes can occur, but it varies by individual. Discuss any concerns with your doctor.
Elderly patients should consult their doctor to ensure Otezla is appropriate for them.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.