Orfadin capsules (Nitisinone)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Orfadin capsules Used For?
Orfadin capsules contain nitisinone, which is used to manage hereditary tyrosinaemia type 1 (HT-1), a condition where the body cannot fully break down the amino acid tyrosine.
Primary Uses
Orfadin is primarily used for treating hereditary tyrosinaemia type 1 (HT-1).
How It Works
Nitisinone works by blocking the breakdown of tyrosine, preventing the accumulation of harmful substances in the body.
Good to know: Orfadin is not addictive.
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How to Take Orfadin capsules
It is important to take Orfadin capsules as directed by your healthcare provider.
Dosage Instructions
The recommended starting dose is 1 mg/kg of body weight per day, divided into two doses. Your doctor may adjust this based on your response and test results.
What If You Miss a Dose?
If you miss a dose, do not take a double dose to make up for it. Consult your doctor or pharmacist for guidance.
Important: Never double your dose to compensate for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- rash
- itching or irritation of the skin
- redness and peeling of skin
- headaches
- stomach pain
- constipation
Seek immediate medical attention if you experience:
- red eyes
- scarring or clouding of the cornea
- inflammation in the cornea
- inflammation in the eye
- inflammation in the eyelids
- sensitivity to light
- eye pain
- shortness of breath
- wheezing or difficulty breathing
- swelling of the face, lips, tongue or other parts of the body
Important Warnings
There are several important considerations when using Orfadin.
Who Should Not Take Orfadin capsules
Do not use Orfadin if you have a known allergy to nitisinone or any of its ingredients.
Medical Conditions to Discuss
Inform your doctor about any other medical conditions you have or medications you are taking.
Pregnancy and Breastfeeding
Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Orfadin should not be used during breastfeeding.
Drug Interactions
Certain medications may interact with Orfadin.
- warfarin
- phenytoin
- furosemide (frusemide)
Alcohol & Driving
Be cautious when driving or operating machinery until you know how Orfadin affects you.
Alcohol
No specific alcohol warnings were mentioned, but consult your doctor for personalized advice.
Driving and Operating Machinery
Orfadin is not known to cause dizziness or lightheadedness, but it may affect vision if side effects occur.
Storage
Store Orfadin capsules in their original container in a refrigerator between 2°C and 8°C. They can also be kept in a cool, dry place below 25°C for up to 2 months.
Overdose Information
If you suspect an overdose of Orfadin, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
Orfadin helps control your condition but does not cure it. The time to notice effects may vary.
Yes, Orfadin should be taken with food.
No, Orfadin is not addictive.
Do not stop taking Orfadin without consulting your doctor, as your condition may worsen.
Consult your doctor for personalized advice regarding alcohol consumption while on Orfadin.
Weight gain is not mentioned as a side effect of Orfadin.
Consult your doctor to determine if Orfadin is safe for elderly patients.
If you miss a dose, do not take a double dose. Consult your doctor or pharmacist for guidance.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.