Ofev (Nintedanib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Ofev Used For?
Ofev is a medication that contains nintedanib and is primarily used to treat certain chronic lung diseases and in combination with other treatments for non-small cell lung cancer (NSCLC).
Primary Uses
Ofev is used to treat idiopathic pulmonary fibrosis (IPF), other chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, systemic sclerosis associated interstitial lung disease (SSc-ILD), and non-small cell lung cancer (NSCLC).
How It Works
Ofev works by inhibiting specific proteins that promote the growth of blood vessels, which cancer cells need for nourishment, thereby helping to slow the progression of cancer and reduce lung scarring.
Good to know: Ofev is not considered addictive.
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How to Take Ofev
Ofev should be taken as prescribed by your healthcare provider, typically with food to enhance absorption.
Dosage Instructions
For NSCLC, the recommended starting dose is two 100 mg capsules taken twice daily (total of 400 mg/day). For IPF and other ILDs, the starting dose is one 150 mg capsule taken twice daily (total of 300 mg/day).
What If You Miss a Dose?
If you miss a dose, skip it if it's almost time for your next dose. Do not take a double dose to make up for the missed one.
Important: Never double the dose to compensate for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Diarrhoea
- Nausea
- Stomach pain
- Vomiting
- Decreased appetite
- Headache
- Weight loss
- High blood pressure
Seek immediate medical attention if you experience:
- Severe allergic reactions
- Major bleeding
- Infections with fever or chills
- Heart attack symptoms
- Stroke symptoms
- Signs of blood clots
- Severe diarrhoea
- Signs of liver problems
- Signs of kidney failure
Important Warnings
Before taking Ofev, it's crucial to be aware of certain warnings and contraindications.
Who Should Not Take Ofev
Do not use Ofev if you are allergic to nintedanib or any of its ingredients.
Medical Conditions to Discuss
Discuss with your doctor if you have liver problems, blood clots, kidney issues, recent bleeding, heart problems, or a history of gastrointestinal perforation.
Pregnancy and Breastfeeding
Ofev should not be taken during pregnancy or while breastfeeding due to potential risks to the baby. Effective contraception is advised during treatment and for at least three months after stopping.
Drug Interactions
Certain medications can interact with Ofev, affecting its efficacy.
- Ketoconazole
- Erythromycin
- Rifampicin
- Carbamazepine
- Phenytoin
- St John's Wort
Alcohol & Driving
Exercise caution with alcohol consumption and operating machinery while taking Ofev.
Alcohol
There are no known interactions between Ofev and alcohol.
Driving and Operating Machinery
Be careful when driving or using machines until you know how Ofev affects you.
Storage
Store Ofev capsules in their blister packaging in a cool, dry place below 25°C, away from moisture and sunlight.
Overdose Information
If you suspect an overdose, seek immediate medical attention by contacting your doctor or going to the nearest hospital.
Frequently Asked Questions
The time it takes for Ofev to show effects can vary by individual and condition being treated.
Yes, Ofev should be taken with food to improve absorption.
No, Ofev is not considered addictive.
Consult your doctor before stopping Ofev, as sudden discontinuation may affect your treatment.
There are no known interactions between Ofev and alcohol, but moderation is advised.
Weight loss is a common side effect of Ofev, not weight gain.
Elderly patients should discuss their health conditions with their doctor before taking Ofev.
If you miss a dose, skip it if it's almost time for your next dose. Do not double up.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.