Nucala (Mepolizumab)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Nucala Used For?
Nucala is a medication that helps manage conditions associated with high levels of eosinophils, a type of white blood cell.
Primary Uses
Nucala is primarily used to treat severe eosinophilic asthma, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis (EGPA), and chronic obstructive pulmonary disease (COPD) with elevated eosinophils.
How It Works
Nucala works by blocking interleukin-5, a protein that promotes the production of eosinophils, thereby reducing their levels in the blood and lungs.
Good to know: Nucala is not addictive.
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How to Take Nucala
Nucala is administered as an injection under the skin by a healthcare professional.
Dosage Instructions
For severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps, the recommended dose is 100 mg every four weeks. For EGPA, the dose is 300 mg, given as three injections every four weeks. For COPD with raised eosinophils, the dose is 100 mg every four weeks.
What If You Miss a Dose?
If you miss a dose of Nucala, contact your doctor or hospital as soon as possible to reschedule your appointment.
Important: Never double the dose if you miss one.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- headache
- injection-site reaction
- fatigue
- fever
- eczema
- back pain
- pharyngitis
- nasal congestion
- lower respiratory tract infection
- chest infection
- upper abdominal pain
- vomiting
- diarrhoea
- urinary tract infection
Seek immediate medical attention if you experience:
- allergic reactions
- shingles infection
Important Warnings
There are specific warnings to consider before using Nucala.
Who Should Not Take Nucala
Do not use Nucala if you have had an allergic reaction to mepolizumab or any of its ingredients, or if you are trying to treat acute asthma or COPD symptoms.
Medical Conditions to Discuss
Discuss with your doctor if you have any other medical conditions, are taking other medications, or have a history of allergic reactions.
Pregnancy and Breastfeeding
Consult your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as the effects of Nucala during these times are not fully known.
Drug Interactions
Some medications may interact with Nucala.
- Corticosteroids
Alcohol & Driving
Be cautious when driving or operating machinery until you know how Nucala affects you.
Alcohol
There are no specific warnings about alcohol consumption with Nucala.
Driving and Operating Machinery
Use caution when driving or operating machinery until you are aware of how Nucala affects you.
Storage
Store Nucala in its original carton to protect it from light. Unopened vials should be kept at 2°C to 8°C (refrigerate, do not freeze) or below 25°C (do not freeze). Do not store in the bathroom or near a sink.
Overdose Information
If you suspect an overdose of Nucala, seek immediate medical attention. Contact your doctor or go to the nearest emergency department.
Frequently Asked Questions
Nucala may take several weeks to show its full effect.
There are no specific dietary restrictions mentioned for taking Nucala.
No, Nucala is not considered addictive.
Do not stop taking Nucala without consulting your doctor, as this may lead to a return of symptoms.
There are no specific warnings regarding alcohol consumption while taking Nucala.
Weight gain is not listed as a side effect of Nucala.
Consult your doctor for advice on the safety of Nucala in elderly patients.
Contact your doctor or hospital as soon as possible to reschedule your appointment.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.