Mektovi (Binimetinib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Mektovi Used For?
Mektovi is an anti-cancer medication that works in combination with another drug called Braftovi to treat specific types of cancer.
Primary Uses
Mektovi is used in combination with Braftovi to treat adults with melanoma that has spread or cannot be surgically removed, and non-small cell lung cancer (NSCLC) that has also spread.
How It Works
Mektovi targets the MEK protein, which promotes cancer cell growth, helping to slow or stop the progression of cancer when used alongside Braftovi, which targets the mutated BRAF protein.
Good to know: Mektovi is not addictive.
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How to Take Mektovi
Follow your doctor's instructions on how to take Mektovi.
Dosage Instructions
The recommended dose is 45 mg, taken as three 15 mg tablets or one 45 mg tablet, twice daily about 12 hours apart, totaling 90 mg per day. Swallow the tablets whole with a full glass of water, with or without food.
What If You Miss a Dose?
If you miss a dose and it's less than 6 hours late, take it as soon as you remember. If it's more than 6 hours late, skip that dose and take your next dose at the usual time. Do not double the dose.
Important: Never take a double dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Fatigue
- Nausea
- Diarrhea
- Vomiting
- Vision problems
- Stomach pain
- Joint pain
- Abnormal blood test results
- Muscle pain
Seek immediate medical attention if you experience:
- Heart problems
- Blood clots
- Severe bleeding
- Eye problems
- Liver issues
- Muscle breakdown (rhabdomyolysis)
- High blood pressure
- Lung or breathing problems
- Tumor lysis syndrome
Important Warnings
There are several important warnings to consider before using Mektovi.
Who Should Not Take Mektovi
Do not use Mektovi if you are allergic to binimetinib or any of its ingredients.
Medical Conditions to Discuss
Discuss any history of heart problems, high blood pressure, muscle issues, blood clots, liver or lung problems, bleeding issues, and eye conditions with your doctor.
Pregnancy and Breastfeeding
Mektovi is not recommended during pregnancy as it may cause harm to an unborn baby. It is also not recommended while breastfeeding.
Drug Interactions
Certain medications may interact with Mektovi and affect its efficacy.
- Any other medications that may increase bleeding risk
- Other treatments for cancer
Alcohol & Driving
Be cautious when driving or operating machinery while taking Mektovi, as it may affect your ability.
Alcohol
Consult your doctor about alcohol consumption while on Mektovi.
Driving and Operating Machinery
Mektovi may impair your ability to drive or operate machinery, especially if you experience vision problems.
Storage
Store Mektovi in its original packaging below 30°C in a cool, dry place, away from moisture and heat.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The time it takes for Mektovi to work can vary by individual, and your doctor will monitor your progress.
Yes, Mektovi can be taken with or without food.
No, Mektovi is not considered addictive.
Do not stop taking Mektovi without consulting your doctor, as it may affect your treatment.
Consult your doctor regarding alcohol consumption while on Mektovi.
Weight gain is not commonly reported as a side effect of Mektovi.
Elderly patients should discuss their health conditions with their doctor to ensure Mektovi is safe for them.
If you miss a dose, take it as soon as you remember if it's less than 6 hours late; otherwise, skip it and continue with your schedule.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.