Lynparza Tablets (Olaparib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Lynparza Tablets Used For?
Lynparza tablets are used to treat specific cancers that have certain genetic markers. They belong to a class of medications known as PARP inhibitors, which target cancer cells that struggle to repair DNA damage.
Primary Uses
Lynparza is used for treating BRCA-mutated ovarian cancer, recurrent ovarian cancer, BRCA-mutated breast cancer, germline BRCA-mutated pancreatic cancer, and BRCA-mutated prostate cancer.
How It Works
Lynparza works by inhibiting the PARP enzyme, which is involved in repairing DNA damage in cancer cells. This leads to the death of cancer cells that cannot effectively repair their DNA.
Good to know: Lynparza is not considered addictive.
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How to Take Lynparza Tablets
It's important to follow your doctor's instructions when taking Lynparza tablets to ensure you receive the correct dosage.
Dosage Instructions
The standard dosage is two 150 mg tablets taken twice daily, totaling four tablets each day. Your doctor may adjust this dosage based on your specific needs.
What If You Miss a Dose?
If you miss a dose, take your next scheduled dose at the usual time. Do not take two doses at once to make up for a missed dose.
Important: Never double your dose to compensate for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- diarrhea
- nausea
- vomiting
- indigestion
- stomach pain
- loss of appetite
- change in taste
- cough
- headache
- dizziness
- tiredness
Seek immediate medical attention if you experience:
- shortness of breath
- tightness in the chest
- swelling of the face or lips
- severe skin reactions
- new or worsening pain in extremities
- inflammation of the lungs
- signs of liver problems (e.g., jaundice, dark urine)
Important Warnings
There are several important considerations to keep in mind before using Lynparza.
Who Should Not Take Lynparza Tablets
Do not use Lynparza if you have a known allergy to olaparib or any of its ingredients.
Medical Conditions to Discuss
Discuss any existing medical conditions with your doctor, especially kidney or liver issues, and any blood disorders.
Pregnancy and Breastfeeding
Lynparza should not be taken during pregnancy as it may harm a developing baby. Both men and women are advised to use effective contraception while on this medication and for a specified period after stopping.
Drug Interactions
Certain medications can interact with Lynparza, affecting its efficacy.
Grapefruit interaction: Avoid grapefruit and Seville oranges as they may affect how Lynparza works.
- Antifungals (e.g., fluconazole, ketoconazole)
- Antibiotics (e.g., clarithromycin, rifampicin)
- Antiviral medications (e.g., ritonavir, indinavir)
- Antiepileptic drugs (e.g., phenytoin, carbamazepine)
- Medications for high blood pressure (e.g., diltiazem, digoxin)
- Statins (e.g., rosuvastatin, atorvastatin)
- Diabetes medications (e.g., glibenclamide, metformin)
- Immunosuppressants (e.g., ciclosporin, tacrolimus)
- Cancer pain medications (e.g., fentanyl)
- Methotrexate
- Quetiapine
- Colchicine
- Dabigatran
Alcohol & Driving
Be cautious with alcohol consumption and operating vehicles while taking Lynparza.
Alcohol
Consult your doctor regarding alcohol use while on Lynparza.
Driving and Operating Machinery
Lynparza may cause dizziness and fatigue; avoid driving or using machinery if you experience these symptoms.
Storage
Store Lynparza tablets in their blister pack in a cool, dry place below 30°C, away from moisture and sunlight.
Overdose Information
In case of overdose, seek immediate medical attention. Contact the Poisons Information Centre at 13 11 26 or go to the nearest hospital.
Frequently Asked Questions
The time it takes for Lynparza to work can vary based on individual response and the type of cancer being treated.
Lynparza can be taken with or without food.
No, Lynparza is not considered addictive.
Do not stop taking Lynparza without consulting your doctor, as it may worsen your condition.
Consult your doctor regarding alcohol consumption while on Lynparza.
Weight gain is not commonly reported as a side effect of Lynparza.
Elderly patients should discuss their overall health with their doctor before starting Lynparza.
If you miss a dose, take your next dose at the scheduled time; do not double up.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.