Lorviqua (Lorlatinib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Lorviqua Used For?
Lorviqua is a medication that contains lorlatinib, primarily used to treat a specific type of lung cancer linked to abnormalities in the anaplastic lymphoma kinase (ALK) gene.
Primary Uses
Lorviqua is used to manage lung cancer associated with ALK gene mutations.
How It Works
Lorviqua inhibits the activity of the ALK tyrosine kinase enzyme, which is involved in the growth of cancer cells.
Good to know: Lorviqua is not considered addictive.
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How to Take Lorviqua
Lorviqua should be taken as prescribed by your doctor, typically once a day.
Dosage Instructions
The recommended dose is 100 mg taken orally once daily. Swallow the tablet whole without crushing, chewing, or splitting.
What If You Miss a Dose?
If you miss a dose and it's less than 4 hours before your next scheduled dose, skip the missed dose. Do not double up on doses.
Important: Never take a double dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Fatigue
- Nausea
- Diarrhea
- Constipation
- Weight gain
Seek immediate medical attention if you experience:
- Allergic reactions
- Neurological issues (e.g., seizures, confusion)
- Mood changes
- Irregular heartbeat
- Liver problems
Important Warnings
It's crucial to be aware of potential risks and contraindications associated with Lorviqua.
Who Should Not Take Lorviqua
Do not take Lorviqua if you have had an allergic reaction to lorlatinib or any of its ingredients.
Medical Conditions to Discuss
Inform your doctor if you have conditions such as high cholesterol, high blood pressure, heart problems, liver issues, or neurological disorders.
Pregnancy and Breastfeeding
Do not use Lorviqua if you are pregnant or breastfeeding, as it may harm your baby. Use effective contraception during treatment and for 21 days after stopping.
Drug Interactions
Certain medications can interact with Lorviqua, affecting its efficacy.
Grapefruit interaction: Avoid grapefruit and grapefruit juice while taking Lorviqua.
- rifampicin
- carbamazepine
- phenytoin
- enzalutamide
- mitotane
- St John's wort
- boceprivir
- efavirenz
- cobicistat
- ritonavir
- itraconazole
- ketoconazole
- posaconazole
- voriconazole
- fluconazole
- troleandomycin
- quinidine
- alfentanil
- fentanyl
- ciclosporin
- sirolimus
- tacrolimus
Alcohol & Driving
Be cautious with alcohol consumption and operating machinery while on Lorviqua.
Alcohol
Discuss alcohol use with your doctor, as it may affect your treatment.
Driving and Operating Machinery
Be careful when driving or using machinery until you know how Lorviqua affects you.
Storage
Store Lorviqua in a cool, dry place below 30°C, away from moisture and heat. Keep out of reach of children.
Overdose Information
If you suspect an overdose, seek medical attention immediately. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The time it takes for Lorviqua to work can vary by individual. Consult your doctor for more specific information.
You can take Lorviqua with or without food, but avoid grapefruit products.
No, Lorviqua is not considered addictive.
Do not stop taking Lorviqua without consulting your doctor, as this may affect your treatment.
Discuss alcohol consumption with your doctor, as it may interact with your treatment.
Weight gain is a possible side effect of Lorviqua; monitor your weight and discuss any concerns with your doctor.
Elderly patients should consult their doctor for a thorough evaluation before starting Lorviqua.
If you miss a dose, skip it if it's close to your next dose. Do not double up.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.