Lazcluze (Lazertinib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Lazcluze Used For?
Lazcluze is a medication that contains lazertinib and is used in combination with amivantamab to treat adults diagnosed with non-small cell lung cancer. This type of cancer can spread in the body and is associated with specific changes in the epidermal growth factor receptor (EGFR) gene.
Primary Uses
Lazcluze is primarily used for treating non-small cell lung cancer that has metastasized and exhibits mutations in the EGFR gene.
How It Works
Lazcluze works by blocking the activity of the EGFR, which may help to slow or stop the growth of lung cancer and potentially reduce tumor size.
Good to know: Lazcluze is not considered addictive.
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How to Take Lazcluze
Lazcluze should be taken as prescribed by your healthcare provider. It is important to follow the dosage instructions carefully.
Dosage Instructions
The recommended dosage of Lazcluze is 240 mg taken once daily. Your doctor may adjust the dose to 160 mg or 80 mg if necessary.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember unless it's less than 12 hours until your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.
Important: Never take a double dose of Lazcluze.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- nail problems
- sores in the mouth
- tingling or numbness
- fatigue
- constipation
- diarrhea
- decreased appetite
- nausea
- vomiting
- fever
- muscle spasms
- skin redness or swelling
- hives
Seek immediate medical attention if you experience:
- difficulty breathing
- persistent cough
- fever indicating lung inflammation
- sharp chest pain
- leg pain or swelling indicating blood clots
- vision problems or eye pain
Important Warnings
It is crucial to be aware of certain warnings before taking Lazcluze.
Who Should Not Take Lazcluze
Do not take Lazcluze if you have a known allergy to lazertinib or any of its ingredients.
Medical Conditions to Discuss
Discuss with your doctor if you have a history of lung inflammation, are taking other medications, or have any other medical conditions.
Pregnancy and Breastfeeding
Lazcluze is not recommended during pregnancy as it may harm an unborn baby. If you become pregnant or plan to become pregnant while taking Lazcluze, inform your doctor immediately. It is also advised not to breastfeed while taking this medication.
Drug Interactions
Certain medications may interact with Lazcluze and affect its efficacy.
- Carbamazepine
- Phenytoin
- Rifampicin
- St. John’s wort
- Midazolam
- Sirolimus
- Tacrolimus
- Rosuvastatin
- Sulfasalazine
Alcohol & Driving
Lazcluze does not affect your ability to drive or operate machinery.
Alcohol
There are no specific warnings regarding alcohol consumption while taking Lazcluze.
Driving and Operating Machinery
You can drive and use machinery safely while taking Lazcluze.
Storage
Store Lazcluze below 30°C in a cool, dry place away from moisture and sunlight. Keep it out of reach of children.
Overdose Information
If you suspect an overdose of Lazcluze, contact your doctor or the Poisons Information Centre at 13 11 26 immediately, even if no symptoms are present.
Frequently Asked Questions
The time it takes for Lazcluze to work can vary by individual, but it is designed to help slow or stop the growth of lung cancer.
You can take Lazcluze with or without food.
No, Lazcluze is not considered addictive.
Do not stop taking Lazcluze without consulting your doctor, as it may affect your treatment.
There are no specific warnings against alcohol consumption while on Lazcluze.
Weight gain is not listed as a common side effect of Lazcluze.
Consult your doctor for advice on the safety of Lazcluze for elderly patients.
If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.