Kombiglyze XR (Saxagliptin And Metformin Hydrochloride)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Kombiglyze XR Used For?
Kombiglyze XR is a medication that combines saxagliptin and metformin hydrochloride to help manage blood sugar levels in individuals with type 2 diabetes mellitus, in conjunction with diet and exercise.
Primary Uses
It is primarily used to lower blood sugar levels in patients with type 2 diabetes mellitus.
How It Works
Saxagliptin is a DPP-4 inhibitor that helps increase insulin levels and decrease glucose production, while metformin reduces sugar production in the liver and improves insulin sensitivity.
Good to know: Kombiglyze XR is not addictive.
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How to Take Kombiglyze XR
Follow your doctor's instructions on how to take Kombiglyze XR. It should be taken with or immediately after food to minimize stomach upset.
Dosage Instructions
Your doctor will prescribe the appropriate dosage based on your individual needs. It is important to take it as directed.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not double the dose.
Important: Never take a double dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Nausea
- Vomiting
- Diarrhea
- Stomach pain
- Loss of appetite
- Headache
- Signs of respiratory infections
Seek immediate medical attention if you experience:
- Severe allergic reactions
- Signs of hypoglycemia
- Heart failure symptoms
- Severe abdominal pain
- Lactic acidosis
Impulse Control Issues
There are no specific mentions of impulse control issues related to Kombiglyze XR.
Important Warnings
There are several important warnings to consider before taking Kombiglyze XR.
Who Should Not Take Kombiglyze XR
Do not take Kombiglyze XR if you are allergic to saxagliptin or metformin, have type 1 diabetes, severe kidney disease, or are experiencing diabetic ketoacidosis.
Medical Conditions to Discuss
Discuss any history of kidney or liver problems, heart failure, or excessive alcohol consumption with your doctor.
Pregnancy and Breastfeeding
Kombiglyze XR is not recommended during pregnancy or breastfeeding. Insulin is preferred for managing blood glucose during pregnancy.
Elderly Patients With Dementia: Elderly patients should be monitored closely due to potential risks associated with diabetes medications.
Drug Interactions
Kombiglyze XR may interact with other medications, affecting how well they work.
Grapefruit interaction: No specific grapefruit interaction mentioned.
- Other diabetes medications
- Alcohol-containing medicines
- Tetracosactrin
- Danazol
- Certain blood pressure and heart medications
- Blood clot prevention medications like warfarin
- Diuretics
- Chlorpromazine
- NSAIDs
- Cimetidine
- Corticosteroids
- Asthma medications
Alcohol & Driving
Caution is advised when consuming alcohol or driving while taking Kombiglyze XR.
Alcohol
Alcohol can affect blood sugar control and may lead to serious side effects.
Driving and Operating Machinery
Be careful when driving or using machinery until you know how Kombiglyze XR affects you, as it may cause dizziness.
Temperature Regulation
No specific temperature regulation warnings mentioned.
Storage
Store Kombiglyze XR in its blister pack in a cool, dry place below 30°C. Keep out of reach of children.
Overdose Information
If you suspect an overdose, contact your doctor or the Poisons Information Centre at 13 11 26 immediately, or go to the nearest hospital.
Frequently Asked Questions
Kombiglyze XR helps lower blood sugar levels, but the time it takes to see results can vary based on individual factors.
Yes, it is recommended to take Kombiglyze XR with or immediately after food to reduce the chance of stomach upset.
No, Kombiglyze XR is not considered addictive.
Do not stop taking Kombiglyze XR without consulting your doctor, as it may lead to uncontrolled blood sugar levels.
You should discuss alcohol consumption with your doctor, as it can affect blood sugar control.
Weight gain is not commonly associated with Kombiglyze XR, but individual responses can vary.
Elderly patients should be monitored closely due to potential risks associated with diabetes medications.
If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not double the dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.