Kesimpta (Ofatumumab)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Kesimpta Used For?
Kesimpta contains ofatumumab, a specialized protein called a monoclonal antibody that targets specific immune system cells to help manage multiple sclerosis.
Primary Uses
Kesimpta is used for treating adults with relapsing forms of multiple sclerosis, helping to reduce relapses and slow disease progression.
How It Works
Ofatumumab is designed to recognize and attach to CD20 targets on B-cells (certain white blood cells). By targeting and removing these B-cells, Kesimpta reduces their activity, which helps decrease the chance of having a relapse, relieves symptoms, and slows down multiple sclerosis progression.
How to Take Kesimpta
Kesimpta is given as an injection under the skin following a specific schedule. Your healthcare provider will train you or your caregiver on proper injection technique before you start.
Dosage Instructions
Inject 20mg under the skin on week 0, week 1, and week 2. There is no injection at week 3. Starting at week 4 and then every month thereafter, inject 20mg under the skin. Follow the Instructions for Use leaflet included in the pack.
What If You Miss a Dose?
If you miss a dose, inject it as soon as possible without waiting for your next scheduled dose. Continue with your regular schedule for following doses. Do not inject a double dose to make up for the missed one.
Important: Do not attempt to inject Kesimpta until you or your caregiver have been properly trained by your healthcare professional on the correct preparation and injection technique.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Upper respiratory infections (sore throat, runny nose)
- Local injection site reactions (redness, pain, itching, swelling)
- General injection reactions (fever, headache, muscle pain, chills, tiredness)
- Urinary tract infections
Seek immediate medical attention if you experience:
- Worsening multiple sclerosis symptoms (muscle weakness, stiffness, spasms, eye changes like blurred or double vision, tremor, general weakness)
- Allergic reactions (rash, hives, trouble breathing, swelling of face, eyelids, lips, mouth, tongue or throat, chest tightness, feeling faint)
- Any unusual or different symptoms
Important Warnings
There are several important safety considerations before starting Kesimpta treatment.
Who Should Not Take Kesimpta
Do not use Kesimpta if you are allergic to ofatumumab or any of the ingredients listed in the medication guide. Always check the ingredients to ensure you can safely use this medicine.
Medical Conditions to Discuss
Tell your doctor if you are at risk of hepatitis B infection (all patients need a blood test before starting), have any infection (especially severe ones), have a weakened immune system, or take medicines for other conditions. Kesimpta cannot be used until severe infections are resolved or your immune system is stronger.
Pregnancy and Breastfeeding
You should avoid becoming pregnant while using Kesimpta and for 6 months after stopping treatment. Use effective contraception during this time. If you become pregnant or think you might be pregnant, tell your doctor immediately. Discuss with your doctor if you are breastfeeding or plan to breastfeed.
Infection Risk: Kesimpta may increase your risk of infections. Tell your doctor immediately if you develop any signs of infection during treatment.
Drug Interactions
Some medications may interfere with Kesimpta and affect how it works. Always inform your healthcare providers about all medicines you’re taking.
- Medicines that lower or modify the immune system
- Other multiple sclerosis treatments (ocrelizumab, cladribine, fingolimod, natalizumab, teriflunomide, mitoxantrone, dimethyl fumarate)
- Vaccines
Alcohol & Driving
There are some considerations regarding alcohol consumption and driving while taking Kesimpta.
Alcohol
There are no known interactions between Kesimpta and alcohol.
Driving and Operating Machinery
It is not known if Kesimpta will influence your ability to drive and use machines. Be careful before driving or using machinery until you know how Kesimpta affects you.
Storage
Store Kesimpta in the refrigerator between 2°C and 8°C. Do not freeze. Keep in the original package and out of reach of children. If necessary, Kesimpta may be stored unrefrigerated for up to 7 days at room temperature (not above 30°C). If not used during this period, it can be returned to the refrigerator for a maximum of 7 days.
Overdose Information
If you think you have used too much Kesimpta, seek urgent medical attention immediately. Contact the Poisons Information Centre (13 11 26), your doctor, or go to the nearest hospital Emergency Department, even if you have no symptoms of discomfort or poisoning.
Frequently Asked Questions
Kesimpta works by targeting and removing B-cells to reduce multiple sclerosis activity. The medication follows a specific schedule with initial doses in weeks 0, 1, and 2, then monthly maintenance doses starting at week 4.
Kesimpta is an injection given under the skin, so food does not affect its administration. Follow your injection schedule regardless of meals.
If you miss a dose, inject it as soon as possible without waiting for your next scheduled dose. Continue with your regular schedule for following doses. Never inject a double dose to make up for a missed one.
There are no known interactions between Kesimpta and alcohol according to the medication information.
Do not stop using Kesimpta suddenly. Always speak to your doctor or pharmacist before deciding to stop taking this medicine.
Yes, you need a blood test to check for Hepatitis B before starting treatment. Your doctor may also do periodic tests to monitor your progress, including checking specific proteins in your blood that help protect against infection.
Tell your doctor if you plan to receive a vaccine. Kesimpta may interact with vaccines, so your healthcare provider needs to know about any planned vaccinations.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.