Jakavi (Ruxolitinib (As Phosphate))
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Jakavi Used For?
Jakavi is a medication that helps manage certain blood disorders by targeting specific pathways in the body.
Primary Uses
Jakavi is primarily used to treat myelofibrosis in adults, polycythemia vera in adults who cannot tolerate or are not adequately controlled with hydroxyurea, and acute or chronic graft-versus-host disease in patients aged 12 years and older.
How It Works
Jakavi works by inhibiting Janus kinases (JAKs), which are involved in the signaling pathways that affect blood cell production and immune responses.
Good to know: Jakavi is not addictive.
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How to Take Jakavi
It is important to follow your doctor's instructions on how to take Jakavi correctly.
Dosage Instructions
Take Jakavi twice a day as directed by your doctor. Swallow the tablets whole with a glass of water, either with or without food. Your doctor may adjust your dose based on your response and blood tests.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose.
Important: Never double dose to make up for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Bruising
- Dizziness
- Headaches
- Constipation
- Fatigue
- Infections
- Fever
- Chills
- Sore throat
- Mouth ulcers
- Nausea
- High blood pressure
- Pale skin
Seek immediate medical attention if you experience:
- Urinary tract infections
- Severe infections
- Shingles
- Increased bruising
- Blood disorders
- Breathing difficulties
Important Warnings
There are several important considerations to keep in mind while using Jakavi.
Who Should Not Take Jakavi
Do not take Jakavi if you are allergic to ruxolitinib or any of its ingredients.
Medical Conditions to Discuss
Discuss any allergies, infections, liver or kidney issues, cardiovascular risk factors, and any history of smoking with your doctor before starting Jakavi.
Pregnancy and Breastfeeding
Do not use Jakavi if you are pregnant or breastfeeding, as it may harm your baby.
Drug Interactions
Some medications may interact with Jakavi and affect its effectiveness.
Grapefruit interaction: Avoid grapefruit or grapefruit juice while taking Jakavi, as it may interfere with how the medication works.
- Ketoconazole
- Itraconazole
- Posaconazole
- Voriconazole
- Ciprofloxacin
- Clarithromycin
- Erythromycin
- Telithromycin
- Atazanavir
- Indinavir
- Nelfinavir
- Ritonavir
- Saquinavir
- Verapamil
- Nifedipine
- Carvedilol
Alcohol & Driving
Be cautious with alcohol consumption and operating vehicles while taking Jakavi.
Alcohol
Avoid alcohol as it may exacerbate side effects.
Driving and Operating Machinery
Do not drive or operate heavy machinery if you experience dizziness.
Storage
Store Jakavi in its original packaging at room temperature, away from moisture and out of reach of children.
Overdose Information
If you suspect an overdose, seek medical attention immediately. Contact your doctor or call the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The time it takes for Jakavi to work can vary by individual, but your doctor will monitor your progress.
Yes, Jakavi can be taken with or without food.
No, Jakavi is not considered addictive.
Do not stop taking Jakavi suddenly without consulting your doctor, as it may worsen your condition.
It is advisable to avoid alcohol while taking Jakavi due to potential interactions.
Weight gain can occur; consult your doctor if you have concerns.
Elderly patients should discuss their health conditions with their doctor before taking Jakavi.
If you miss a dose, take it as soon as you remember unless it's almost time for your next dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.