Giotrif (Afatinib Dimaleate)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Giotrif Used For?
Giotrif is a medication used to treat adult patients diagnosed with non-small cell lung cancer (NSCLC).
Primary Uses
It is specifically indicated for non-squamous NSCLC with mutations in the EGFR gene and for squamous NSCLC if the cancer has progressed after chemotherapy.
How It Works
Giotrif works by blocking the activity of proteins in the ErbB family, including the Epidermal Growth Factor Receptor (EGFR), which are involved in the growth and spread of cancer cells.
Good to know: Giotrif is not considered addictive.
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How to Take Giotrif
It is important to take Giotrif as directed by your healthcare provider.
Dosage Instructions
The recommended dosage is one 40 mg tablet taken once daily. It should be swallowed whole with water and not crushed or chewed. Take it on an empty stomach, at least 3 hours after eating and 1 hour before eating.
What If You Miss a Dose?
If you miss a dose and it's less than 8 hours until your next scheduled dose, skip the missed dose. Otherwise, take it as soon as you remember, but do not double the dose.
Important: Never take a double dose to make up for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- skin reactions such as acne-like rash
- mouth sores and inflammation
- nail problems
- loss of appetite or weight changes
- nosebleeds
- pain, redness, swelling, or peeling of skin on hands and feet
- burning sensations during urination
- abnormal taste sensations
- stomach pain, indigestion, heartburn
- lip inflammation
- runny nose
- muscle spasms
- fever
- nausea
- vomiting
Seek immediate medical attention if you experience:
- signs of dehydration such as headache, dizziness, or decreased urine output
- severe skin reactions like peeling or blistering
- severe stomach pain, fever, chills, or vomiting
- sudden or worsening eye problems
- breathlessness or swelling in the body
- severe diarrhea
Important Warnings
There are several important warnings to consider before taking Giotrif.
Who Should Not Take Giotrif
Do not take Giotrif if you have a known allergy to afatinib dimaleate or any of its ingredients.
Medical Conditions to Discuss
Inform your doctor if you have liver or kidney problems, a history of heart issues, lung inflammation, gastrointestinal problems, or if you are taking medications that may increase the risk of gastrointestinal perforation.
Pregnancy and Breastfeeding
Giotrif should not be taken during pregnancy as it may harm the developing baby. Women who could become pregnant should use effective contraception during treatment and for at least 2 weeks after the last dose. Breastfeeding is not recommended while taking Giotrif.
Drug Interactions
Certain medications can interact with Giotrif and affect its effectiveness.
- ritonavir, nelfinavir, saquinavir (HIV medications)
- ciclosporin, tacrolimus (immune suppressants)
- ketoconazole, itraconazole (fungal infection treatments)
- erythromycin, rifampicin (antibiotics)
- verapamil (high blood pressure treatment)
- amiodarone (irregular heartbeat treatment)
- carbamazepine, phenytoin, phenobarbital (seizure medications)
- herbal medicines derived from St John's wort
- quinidine (irregular heartbeat treatment)
- sulfasalazine (anti-inflammatory)
- rosuvastatin (cholesterol-lowering medication)
Alcohol & Driving
Be cautious with alcohol consumption and operating vehicles or machinery while on Giotrif.
Alcohol
Consult your doctor regarding alcohol consumption while taking Giotrif.
Driving and Operating Machinery
Be careful when driving or operating machinery until you know how Giotrif affects you.
Storage
Store Giotrif in a cool, dry place below 30°C. Keep it in the blister pack until you are ready to take it to protect from moisture and light.
Overdose Information
If you suspect an overdose of Giotrif, seek immediate medical attention. Contact the Poisons Information Centre or go to the nearest hospital emergency department.
Frequently Asked Questions
The time it takes for Giotrif to show effects can vary by individual, and it's important to follow your doctor's guidance.
Giotrif should be taken on an empty stomach, at least 3 hours after eating and 1 hour before eating.
No, Giotrif is not considered addictive.
Do not stop taking Giotrif without consulting your doctor, as it may affect your treatment.
Consult your doctor regarding alcohol consumption while on Giotrif.
Weight changes can occur, and it's important to monitor your weight and discuss any concerns with your doctor.
Elderly patients should discuss their overall health and any medications with their doctor before starting Giotrif.
If you miss a dose and it's less than 8 hours until your next dose, skip the missed dose. Otherwise, take it as soon as you remember, but do not double the dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.