Entyvio Pen (Vedolizumab)

Complete patient guide for uses, dosage, side effects, and safety information

Prescription Required

Quick Facts

Generic Name

vedolizumab

Drug Class

monoclonal antibody

Used For

treating moderate to severe ulcerative colitis and Crohn's disease

How Taken

subcutaneous injection every 2 weeks after initial intravenous doses

What Is Entyvio Pen Used For?

Entyvio Pen is a pre-filled pen containing vedolizumab, used to manage symptoms of moderate to severe ulcerative colitis and Crohn's disease in adults who have not adequately responded to other treatments.

Primary Uses

Moderate to severe ulcerative colitis and moderate to severe Crohn's disease.

How It Works

Vedolizumab works by blocking integrin α4β7, which helps reduce inflammation associated with ulcerative colitis and Crohn's disease.

Good to know: Entyvio is not addictive.

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How to Take Entyvio Pen

Entyvio is administered via subcutaneous injection after initial intravenous infusions.

Dosage Instructions

The recommended dose is 108 mg (1 pre-filled pen) injected subcutaneously every 2 weeks after at least 2 initial intravenous doses.

What If You Miss a Dose?

If you miss a dose, inject it as soon as possible and continue with the regular schedule. Do not double the dose.

Important: Never double dose to make up for a missed dose.

Side Effects

Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.

Common Side Effects

These side effects occur relatively frequently and usually don’t require emergency care:

common cold
joint pain
headache
fever
flu (influenza)
nose or throat infection
bronchitis
chest infection
cough
throat pain
nausea
itching
rash and redness
pain in the extremities
back pain
tiredness
injection site reactions (pain, swelling, redness, or itching)

Seek immediate medical attention if you experience:

allergic reactions (wheezing, difficulty breathing, hives, swelling)
infections
liver injury (chills, high fever, jaundice)
inflammation of the pancreas (severe stomach pain, nausea)
kidney inflammation (changes in urine output, blood in urine)

Important Warnings

There are specific warnings and contraindications for using Entyvio.

Who Should Not Take Entyvio Pen

Do not use Entyvio if you have had an allergic reaction to vedolizumab or any of its ingredients, or if you have an active severe infection.

Medical Conditions to Discuss

Discuss any infections, allergies, or if you are receiving vaccinations with your doctor.

Pregnancy and Breastfeeding

Consult your doctor if you are pregnant or breastfeeding, as the effects of Entyvio during pregnancy are not well known.

Drug Interactions

Some medications may interfere with how Entyvio works.

Other biologic medicines that suppress the immune system
Natalizumab
Rituximab

Alcohol & Driving

Be cautious when driving or operating machinery until you know how Entyvio affects you.

Alcohol

Consult your doctor regarding alcohol consumption while on Entyvio.

Driving and Operating Machinery

If you feel dizzy after using Entyvio, do not drive or use machinery.

Storage

Store Entyvio in the refrigerator at 2°C to 8°C. Do not freeze. A single pre-filled pen can be kept at room temperature (up to 25°C) for up to 7 days, protected from light.

Overdose Information

If you suspect an overdose, seek immediate medical attention by contacting your doctor or going to the nearest hospital.

Frequently Asked Questions

The effects of Entyvio may vary, but it is typically used as part of a long-term treatment plan.

There are no specific instructions regarding food interactions with Entyvio.

No, Entyvio is not considered addictive.

Do not stop taking Entyvio without consulting your doctor, as it may worsen your condition.