Endep (Amitriptyline Hydrochloride)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Endep Used For?
Endep is a medication that contains amitriptyline hydrochloride, primarily used for managing depression and, in some cases, bedwetting when no physical cause is identified.
Primary Uses
Endep is mainly prescribed for treating depression and can also be used to address bedwetting in children.
How It Works
Endep works by correcting the imbalance of certain chemicals in the brain that affect mood, helping to alleviate the symptoms of depression.
Good to know: Endep is not considered addictive.
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How to Take Endep
Endep should be taken as directed by your healthcare provider, with specific instructions on dosage and timing.
Dosage Instructions
For depression, the typical starting dose is between 75 mg to 150 mg per day, divided into smaller doses. For bedwetting, lower doses are recommended based on the child's age and weight.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember unless it's close to the time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose.
Important: Never double your dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- dry mouth
- altered sense of taste
- nausea
- vomiting
- diarrhea
- constipation
- blurred vision
- difficulty focusing
- drowsiness
- tiredness
- headache
- dizziness
- lightheadedness
- increased sweating
- weight changes
- changes in sex drive
Seek immediate medical attention if you experience:
- fast or irregular heartbeats
- larger breasts than normal
- tingling or numbness in hands or feet
- uncontrolled movements
- difficulty passing urine
- signs of frequent infections
- yellowing of the skin or eyes
- unusual bruising or bleeding
- feeling anxious or confused
- hallucinations
- mood swings
Impulse Control Issues
Patients may experience impulse control problems, including gambling or spending issues.
Important Warnings
There are several important considerations to keep in mind when taking Endep.
Who Should Not Take Endep
Do not take Endep if you have had an allergic reaction to it or any of its ingredients, if you have recently had a heart attack, or if you are taking cisapride or monoamine oxidase inhibitors (MAOIs).
Medical Conditions to Discuss
Inform your doctor if you have heart or blood vessel issues, liver problems, glaucoma, urinary difficulties, thyroid issues, seizures, or any mental health conditions other than depression.
Pregnancy and Breastfeeding
Consult your doctor if you are pregnant or planning to become pregnant, as there may be risks. Do not take Endep while breastfeeding, as it can pass into breast milk and harm your baby.
Elderly Patients With Dementia: Caution is advised for elderly patients, particularly those with dementia, as they may be more sensitive to the effects of Endep.
Drug Interactions
Endep may interact with various medications, affecting how it works or increasing the risk of side effects.
- cisapride
- monoamine oxidase inhibitors (MAOIs)
- selective serotonin reuptake inhibitors (SSRIs)
- medications for high blood pressure
- anticholinergics
- medications for schizophrenia
- quinidine and flecainide
- cimetidine
- sleeping tablets/sedatives
- anti-anxiety medications
- medications for epilepsy
- thyroid medications
- disulfiram
- tramadol
Alcohol & Driving
Caution is advised when consuming alcohol or operating machinery while taking Endep.
Alcohol
Combining Endep with alcohol can increase drowsiness and dizziness. It is advisable to avoid alcohol during treatment.
Driving and Operating Machinery
Endep may impair your ability to drive or operate machinery. Avoid these activities until you know how the medication affects you.
Storage
Store Endep in a cool, dry place below 25°C, away from moisture and heat. Keep it out of reach of children.
Overdose Information
Taking too much Endep can be dangerous and may lead to severe symptoms. If an overdose is suspected, seek immediate medical attention or contact the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
Some people may notice improvements in their symptoms within 3 to 4 days, but it can take up to 4 weeks to feel the full effects.
Endep can be taken with or without food.
No, Endep is not considered addictive.
Stopping Endep suddenly may cause withdrawal symptoms. Always consult your doctor before discontinuing the medication.
It is advisable to avoid alcohol as it can increase drowsiness and dizziness.
Weight changes, either gain or loss, can occur while taking Endep.
Elderly patients should use Endep with caution, especially those with dementia.
If you miss a dose, take it as soon as you remember unless it's close to your next dose. Do not double the dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.