Enbrel (Etanercept)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Enbrel Used For?
Enbrel is a medication that helps manage certain inflammatory conditions by targeting specific proteins in the body.
Primary Uses
Enbrel is primarily used to treat rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, psoriatic arthritis, and plaque psoriasis.
How It Works
Enbrel works by binding to and inactivating Tumour Necrosis Factor (TNF), a substance in the body that contributes to inflammation and pain in the joints.
Good to know: Enbrel is not addictive.
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How to Take Enbrel
Enbrel is administered through injections, and it's important to follow your doctor's instructions carefully.
Dosage Instructions
For adults, the typical dose is 50 mg once a week or two 25 mg doses spaced 3-4 days apart. For children, the dose varies based on weight and condition.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember unless it's close to the time for your next dose. In that case, skip the missed dose and continue with your regular schedule.
Important: Never double the dose if you miss one.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- injection site reactions (itching, bruising, redness, pain)
- infections (cold, sinus infections)
- allergic reactions (wheezing, rash, itching)
- headaches
- fever
Seek immediate medical attention if you experience:
- infections (tuberculosis, sepsis)
- lung disease (breathlessness, dry cough)
- nerve disorders (seizures, numbness)
- inflammatory bowel symptoms (diarrhea, stomach cramps)
- kidney issues (swelling, changes in urination)
- severe allergic reactions (swelling of face, difficulty breathing)
- heart failure symptoms (shortness of breath, swelling)
Important Warnings
There are several important considerations to keep in mind when using Enbrel.
Who Should Not Take Enbrel
Do not use Enbrel if you have had an allergic reaction to etanercept or any of its ingredients, have a history of serious infections like sepsis, or are currently taking certain other medications like anakinra.
Medical Conditions to Discuss
Discuss with your doctor if you have a history of infections, liver problems, heart failure, or are about to undergo major surgery.
Pregnancy and Breastfeeding
Consult your doctor if you are pregnant or planning to become pregnant, as the effects of Enbrel during pregnancy are not well understood. Contraception is advised during treatment and for 3 weeks after stopping. Small amounts may pass into breast milk.
Drug Interactions
Certain medications may interact with Enbrel and affect its effectiveness.
- abatacept
- anakinra
- cyclophosphamide
- sulfasalazine
- some vaccines
- warfarin
- digoxin
- medications for diabetes
Alcohol & Driving
There are no specific warnings about alcohol consumption or driving while taking Enbrel.
Alcohol
No specific information is available regarding alcohol consumption with Enbrel.
Driving and Operating Machinery
It is not known whether Enbrel causes dizziness or drowsiness, so exercise caution.
Storage
Store Enbrel in the refrigerator between 2°C and 8°C. Do not freeze. Protect from light and moisture. If stored at room temperature, use within 4 weeks.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The effects of Enbrel can vary, but it may take several weeks to notice improvement in your condition.
There is no specific information regarding food interactions with Enbrel.
No, Enbrel is not considered addictive.
Do not stop taking Enbrel suddenly without consulting your doctor, as your condition may worsen.
There are no specific warnings about alcohol consumption while taking Enbrel.
There is no information available regarding weight gain as a side effect of Enbrel.
Elderly patients should discuss their overall health and any specific concerns with their doctor before starting Enbrel.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.