Coversyl Plus (Perindopril Arginine And Indapamide Hemihydrate)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Coversyl Plus Used For?
Coversyl Plus is prescribed specifically for treating high blood pressure (hypertension). It contains two active ingredients that work together to help lower your blood pressure.
Primary Uses
Coversyl Plus is used to treat high blood pressure. High blood pressure occurs when your blood pressure stays higher than needed, even when you are calm and relaxed. If left untreated, it can lead to serious health problems including stroke, heart disease, and kidney failure.
How It Works
Coversyl Plus contains perindopril (an ACE inhibitor) and indapamide (a diuretic or 'water tablet'). These ingredients work together to help lower your blood pressure and reduce the strain on your cardiovascular system.
Good to know: There is no evidence that Coversyl Plus is addictive.
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How to Take Coversyl Plus
Follow all directions given by your doctor and pharmacist carefully. Your doctor will select the right dose for you when prescribing Coversyl Plus.
Dosage Instructions
The usual dose is one tablet once daily. Swallow your tablet with water, preferably in the morning. Coversyl Plus treatment is usually for life, so you should keep taking the tablets regularly unless advised otherwise by your doctor.
What If You Miss a Dose?
If your next usual dose is less than 6 hours away, just leave out the dose that you missed and take the next dose at the usual time. If your next dose is more than 6 hours away, take the missed dose as soon as you realize, then take the next dose at the usual time and continue as normal.
Important: Do not try to make up for missed doses by taking more than one dose at a time.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Dry cough and shortness of breath
- Nosebleeds
- Headache, dizziness, pins and needles
- Feeling tired or weak
- Ringing in ears, vision problems
- Low blood pressure and flushing
- Low potassium levels
- Nausea, vomiting, stomach problems
- Dry mouth and decreased appetite
- Muscle spasms and weakness
- Skin rash and itching
Seek immediate medical attention if you experience:
- Severe dizziness or fainting from low blood pressure
- Difficulty breathing or wheezing
- Severe allergic reaction with swelling of face, lips, tongue, or throat
- Purple spots with blisters on skin
- Painful red areas with large blisters and peeling skin
- Stroke symptoms (weakness, speech problems)
- Heart problems (irregular heartbeat, chest pain)
- Liver disease (yellowing of skin or eyes)
- Muscle breakdown with pain and weakness
Important Warnings
There are important situations where Coversyl Plus should not be taken, and conditions that require special monitoring.
Who Should Not Take Coversyl Plus
Do not take if you are: allergic to perindopril, indapamide, sulfonamide antibiotics, thiazide diuretics, or other ACE inhibitors; pregnant or trying to become pregnant; breastfeeding; undergoing certain blood treatments; taking aliskiren with diabetes or kidney problems; have kidney artery problems; have severe liver disease; have experienced serious swelling reactions (angioedema); taking sacubitril/valsartan; have low blood potassium; or if packaging is damaged or expired.
Medical Conditions to Discuss
Tell your doctor if you have: kidney or liver disease, diabetes, gout, heart disease, high or low potassium/sodium levels, hyperparathyroidism, lupus or scleroderma, vision problems, muscle disorders, or if you are of African origin (higher risk of angioedema and medication may be less effective).
Pregnancy and Breastfeeding
Do not take Coversyl Plus if you are pregnant, trying to become pregnant, or breastfeeding. Tell your doctor immediately if you become pregnant while taking this medication as it may cause serious harm to your unborn baby.
Elderly Patients: Elderly people can generally use Coversyl Plus safely, but some older people have reduced kidney function and may require additional care. Not recommended for children and adolescents.
Drug Interactions
Coversyl Plus may interact with many medications. Always tell your doctor about all medicines you are taking, including over-the-counter medications.
- Steroid medicines
- Other diuretics (water tablets)
- Heart rhythm medications
- Blood pressure medications (ACE inhibitors, ARBs, aliskiren)
- Antibiotics and infection treatments
- Anti-inflammatory medicines (aspirin, ibuprofen)
- Mental health medications (lithium, antidepressants, antipsychotics)
- Diabetes medications
- Potassium supplements and salt substitutes
- Cancer treatments
- Blood thinners
- Contrast agents for medical tests
Alcohol & Driving
Be careful when driving or operating machinery until you know how Coversyl Plus affects you, as it may cause dizziness or light-headedness.
Alcohol
No specific alcohol warnings mentioned in the source material. Consult your doctor about alcohol consumption.
Driving and Operating Machinery
You may feel light-headed or dizzy when you begin taking Coversyl Plus because your blood pressure is falling. If you have these symptoms when standing up or getting out of bed, get up more slowly to help your body adjust to the change in position and blood pressure.
Temperature Regulation
Make sure you drink enough water during exercise and hot weather, especially if you sweat a lot. This will help you avoid dizziness or light-headedness caused by a sudden drop in blood pressure.
Storage
Keep Coversyl Plus tablets where children cannot reach them – a locked cupboard at least one-and-a-half metres above ground is ideal. Keep tablets in their original pack until it's time to take them, as they won't keep as well outside their container. Store in a cool, dry place where temperature stays below 30°C. Don't store in bathrooms, near sinks, in cars, or on windowsills as heat and dampness can destroy the medicine.
Overdose Information
Taking too much Coversyl Plus may cause dangerously low blood pressure, making you feel dizzy. Other effects may include nausea, vomiting, cramps, sleepiness, confusion, and changes in urine production. If overdose is suspected, act immediately: telephone your doctor, Poisons Information Centre (13 11 26 in Australia; 03 474 7000 in New Zealand), or go to the nearest hospital emergency department, even if there are no obvious symptoms. If you feel dizzy from low blood pressure, lying down with legs elevated can help.
Frequently Asked Questions
The source doesn't specify exact timing, but Coversyl Plus helps control blood pressure as an ongoing treatment. Your doctor will monitor your response to determine effectiveness.
The medication should be taken with water, preferably in the morning. No specific food restrictions are mentioned in the source material.
No, there is no evidence that Coversyl Plus is addictive.
Do not stop taking Coversyl Plus or change the dose without checking with your doctor. The treatment is usually for life to control blood pressure, and stopping suddenly could be harmful.
Yes, elderly people can generally use Coversyl Plus safely. However, some older people have reduced kidney function and may require additional care from their doctor.
If your next dose is less than 6 hours away, skip the missed dose. If more than 6 hours away, take the missed dose as soon as you remember, then continue with your regular schedule. Never take two doses at once.
You should drink enough water during exercise and hot weather, especially if you sweat a lot, to help avoid dizziness or light-headedness caused by a sudden drop in blood pressure.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.