Alyftrek (Vanzacaftor, Tezacaftor, Deutivacaftor)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Alyftrek Used For?
Alyftrek is a medication that helps manage cystic fibrosis by improving lung function in patients with certain genetic mutations.
Primary Uses
Alyftrek is primarily used to treat cystic fibrosis in patients aged 6 years and older who have at least one responsive mutation in the CFTR gene.
How It Works
Alyftrek works by increasing the amount of CFTR protein at the cell surface and enhancing its function, improving the flow of chloride and water in the lungs.
Good to know: Alyftrek is not addictive.
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How to Take Alyftrek
It's important to take Alyftrek as prescribed by your doctor to ensure its effectiveness.
Dosage Instructions
The usual dose for patients aged 6 to less than 12 years who weigh 40 kg or more, or patients aged 12 years and older is two purple tablets stamped with 'V10' once daily. For patients aged 6 to less than 12 years who weigh less than 40 kg, the dose is three purple tablets stamped with 'V4' once daily.
What If You Miss a Dose?
If you miss a dose and it's been less than 6 hours, take it as soon as possible. If more than 6 hours have passed, skip the missed dose and continue with your regular schedule. Do not take a double dose.
Important: Never double the dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Headache
- Diarrhoea
- Rash
Seek immediate medical attention if you experience:
- Increased liver enzymes
- Liver damage
- Signs of liver problems such as significant abdominal pain, yellowing of skin or eyes, loss of appetite, nausea, vomiting, dark urine
Important Warnings
There are important considerations to keep in mind before using Alyftrek.
Who Should Not Take Alyftrek
Do not use Alyftrek if you are allergic to any of its ingredients.
Medical Conditions to Discuss
Discuss any history of liver or kidney disease with your doctor before starting Alyftrek.
Pregnancy and Breastfeeding
Consult your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as the effects of Alyftrek during these times are not fully known.
Drug Interactions
Certain medications may interact with Alyftrek and affect its efficacy.
Grapefruit interaction: Avoid grapefruit and grapefruit juice while taking Alyftrek, as they may increase side effects.
- Antifungal medicines (e.g., ketoconazole, itraconazole)
- Antibiotic medicines (e.g., telithromycin, clarithromycin)
- Anticonvulsant medicines (e.g., phenobarbital, carbamazepine)
- Herbal medicine (e.g., St. John's Wort)
- Immunosuppressants (e.g., ciclosporin, everolimus)
- Cardiac glycosides (e.g., digoxin)
- Anticoagulants (e.g., warfarin)
- Medicines for diabetes (e.g., glimepiride, glipizide)
- Medicines for lowering blood cholesterol (e.g., pitavastatin)
- Medicines for lowering blood pressure (e.g., verapamil)
Alcohol & Driving
Alyftrek is not expected to impair your ability to drive or operate machinery.
Alcohol
Consult your doctor regarding alcohol consumption while on Alyftrek.
Driving and Operating Machinery
Alyftrek should not affect your ability to drive or operate machinery.
Storage
Store Alyftrek below 30°C in a dry place, away from moisture, heat, and sunlight. Keep out of reach of children.
Overdose Information
If you suspect an overdose of Alyftrek, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The time it takes for Alyftrek to show effects can vary by individual, but it is designed to improve lung function and reduce symptoms of cystic fibrosis.
Yes, Alyftrek should be taken with fat-containing food to enhance its absorption.
No, Alyftrek is not considered addictive.
Do not stop taking Alyftrek without consulting your doctor, as it may affect your lung function.
Consult your doctor regarding alcohol consumption while on Alyftrek.
Weight gain is not a commonly reported side effect of Alyftrek.
Elderly patients should discuss their health conditions with their doctor before taking Alyftrek.
If you miss a dose, take it as soon as possible if it's within 6 hours; otherwise, skip it and continue with your regular schedule.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.