Rozlytrek (Entrectinib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Rozlytrek Used For?
Rozlytrek is a medication used to treat specific types of cancer, particularly those that are ROS1-positive or have NTRK gene fusions.
Primary Uses
Rozlytrek is primarily used for treating ROS1-positive lung cancer and cancers with NTRK gene fusions in both adults and children aged 12 and older.
How It Works
Rozlytrek works by blocking the action of certain enzymes that are altered due to changes in the ROS1 or NTRK genes, which can promote cancer cell growth.
Good to know: Rozlytrek is not addictive.
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How to Take Rozlytrek
Rozlytrek should be taken as prescribed by your doctor, following specific dosage instructions.
Dosage Instructions
The usual dose for adults is 600 mg, taken as three 200 mg capsules once a day. For children and adolescents, the dosage will be determined by the doctor based on weight and height.
What If You Miss a Dose?
If you miss a dose and it's almost time for your next one, skip the missed dose. If it's more than 12 hours until your next dose, take the missed dose as soon as you remember.
Important: Do not double dose to make up for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- diarrhea
- constipation
- nausea
- vomiting
- stomach pain
- muscle weakness
- fatigue
- fever
- changes in taste
- headache
Seek immediate medical attention if you experience:
- persistent coughing or wheezing
- shortness of breath
- swelling in legs or arms
- dizziness or light-headedness
- confusion
- hallucinations
- nausea or vomiting
- muscle cramps
- decreased urination
- seizures
Important Warnings
There are important considerations to keep in mind before taking Rozlytrek.
Who Should Not Take Rozlytrek
Do not take Rozlytrek if you are allergic to entrectinib or any of its ingredients.
Medical Conditions to Discuss
Discuss any heart problems, liver or kidney issues, and inherited conditions like galactose intolerance with your doctor before starting Rozlytrek.
Pregnancy and Breastfeeding
Rozlytrek may harm an unborn baby. Women should use effective contraception during treatment and for at least 5 weeks after. Men should use contraception for at least 3 months after treatment. Do not breastfeed while taking Rozlytrek.
Drug Interactions
Certain medications may interact with Rozlytrek and affect its effectiveness.
Grapefruit interaction: Avoid grapefruit juice and grapefruit while taking Rozlytrek, as it may increase the medication's levels in your blood.
- nilotinib
- topotecan
- lapatinib
- mitoxantrone
- everolimus
- sirolimus
- St. John's Wort
- ritonavir
- saquinavir
- ketoconazole
- itraconazole
- voriconazole
- posaconazole
- phenytoin
- carbamazepine
- phenobarbital
- rifampicin
- rifabutin
Alcohol & Driving
Be cautious with alcohol consumption and operating machinery while on Rozlytrek.
Alcohol
Consult your doctor regarding alcohol consumption while taking Rozlytrek.
Driving and Operating Machinery
Be careful when driving or using heavy machinery until you know how Rozlytrek affects you, as it may cause dizziness or confusion.
Storage
Store Rozlytrek at room temperature (below 30°C) in its original bottle, tightly closed, and out of reach of children.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact the Poisons Information Centre at 13 11 26 or go to the nearest hospital.
Frequently Asked Questions
The time it takes for Rozlytrek to work can vary by individual and condition. Consult your doctor for specific expectations.
Rozlytrek can be taken with or without food.
No, Rozlytrek is not considered addictive.
Do not stop taking Rozlytrek suddenly without consulting your doctor, as it may worsen your condition.
Consult your doctor regarding alcohol consumption while on Rozlytrek.
Weight gain is not specifically mentioned as a side effect, but discuss any concerns with your doctor.
Elderly patients should discuss their overall health and any specific concerns with their doctor before taking Rozlytrek.
If you miss a dose, skip it if it's almost time for your next dose. If it's more than 12 hours until your next dose, take it as soon as you remember.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.