Prolia (Denosumab)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Prolia Used For?
Prolia is a medication that helps strengthen bones and reduce the risk of fractures.
Primary Uses
Prolia is used to treat osteoporosis in postmenopausal women, men with osteoporosis, men with prostate cancer experiencing bone loss due to reduced testosterone, and to improve bone density in patients on corticosteroids.
How It Works
Denosumab, the active ingredient in Prolia, binds to a specific protein that prevents the formation of bone-resorbing cells, thereby strengthening bones.
Good to know: Prolia is not addictive.
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How to Take Prolia
Prolia is administered as an injection under the skin, typically in a healthcare setting or at home by a trained individual.
Dosage Instructions
The recommended dose of Prolia is 60 mg, given as a single injection every 6 months.
What If You Miss a Dose?
If you miss a dose of Prolia, administer it as soon as possible. After that, continue with the schedule of every 6 months from the last injection date.
Important: Never double your dose of Prolia.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Back, muscle or joint pain
- Aching muscles
- Unusual hair loss or thinning
- Itchy, red or dry skin
- Ear pain or infection
Seek immediate medical attention if you experience:
- Signs of an allergic reaction (e.g., difficulty breathing, swelling)
- Symptoms of low blood calcium (e.g., muscle spasms, numbness)
- Persistent mouth or jaw pain
- Signs of skin infection (e.g., redness, swelling)
- Unusual fractures in the thigh
Important Warnings
There are several important considerations before using Prolia.
Who Should Not Take Prolia
Do not use Prolia if you have low calcium levels, are pregnant or breastfeeding, are under 18 years old, or have had an allergic reaction to denosumab.
Medical Conditions to Discuss
Inform your doctor if you have calcium or vitamin D deficiency, severe kidney problems, or dental issues, as these may affect your treatment.
Pregnancy and Breastfeeding
Prolia should not be used during pregnancy or breastfeeding due to potential risks to the unborn baby and unknown effects on breast milk.
Elderly Patients With Dementia: Special caution is advised for elderly patients, particularly those with dementia.
Drug Interactions
Some medications may interfere with Prolia's effectiveness.
- Other medications containing denosumab (e.g., Xgeva)
Alcohol & Driving
While Prolia does not have known effects on driving, exercise caution until you know how it affects you.
Alcohol
Consult your doctor regarding alcohol consumption while on Prolia.
Driving and Operating Machinery
Be careful when driving or using machinery until you are familiar with how Prolia affects you.
Storage
Store Prolia in the refrigerator at 2°C to 8°C, protected from light. Do not freeze or shake the pre-filled syringe.
Overdose Information
If you suspect an overdose of Prolia, contact your doctor or the Poisons Information Centre at 13 11 26 immediately.
Frequently Asked Questions
Prolia may take several months to show its full effect on bone density.
There are no specific dietary restrictions mentioned for Prolia.
No, Prolia is not considered addictive.
Stopping Prolia may increase your risk of fractures, especially if you have a history of broken bones.
Consult your doctor regarding alcohol consumption while on Prolia.
Weight gain is not listed as a common side effect of Prolia.
Elderly patients should use Prolia with caution, particularly those with dementia.
If you miss a dose, administer it as soon as possible and continue with the 6-month schedule from the last injection date.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.