Prostin E2 (Dinoprostone)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Prostin E2 Used For?
Prostin E2 Vaginal Gel contains dinoprostone, which acts like a natural substance in your body called prostaglandin E2. It is used to help start labor in pregnant women when the baby’s position and cervix characteristics are suitable for delivery.
Primary Uses
Prostin E2 is used to bring on (induce) labor in pregnant women whose baby position and womb (cervix) characteristics are suitable for vaginal delivery.
How It Works
It works by softening and opening the entrance of the womb (cervix) and stimulating contractions, which can start labor.
How Prostin E2 Is Given
Prostin E2 Vaginal Gel is administered only by healthcare professionals trained in pregnancy and childbirth care. It comes in a pre-filled syringe applicator that is gently inserted into the vagina while you are lying down.
Administration Instructions
The gel is released from the syringe applicator while you are lying down. You must stay lying down for at least 30 minutes after receiving Prostin E2. Your doctor will decide the appropriate dose and frequency. During treatment, your contractions and the baby’s heart rate will be closely monitored.
Important: You must remain lying down for at least 30 minutes after receiving the gel, and both you and your baby will be closely monitored throughout treatment.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- nausea, vomiting
- diarrhea
- back pain
- itching, burning/warmth, redness, swelling of the vagina
- fever
- facial flushes
- shivering
- dizziness
- fast dilation of the cervix
Seek immediate medical attention if you experience:
- excessive frequency or strength of contractions or any bleeding
- headache
- nose bleeds
- difficulty breathing
- stomach or chest pain
- blurred vision
- sudden signs of allergy (shortness of breath, wheezing, swelling of face/lips/tongue, rash, itching or hives)
- dizziness or feeling faint
- infection
- severe allergic response to amniotic fluid mixing with blood
- heavy bleeding after birth
- breaking of placenta or uterus
- heart attack
- fetal distress
- still births
Important Warnings
Prostin E2 should not be used in certain situations and requires careful consideration of your medical history and current pregnancy status.
Who Should Not Take Prostin E2
Do not use if you: are allergic to dinoprostone or any ingredients; have given birth 5 or more times; have had previous surgery involving the womb; the baby’s head is too big or your pelvis is too small for normal delivery; there is evidence the baby is unwell or not growing; the baby’s head is not in normal position or not well down in the pelvis; you have had unexplained vaginal discharge or bleeding during current pregnancy; vaginal delivery is not suitable (e.g., active genital herpes); you are carrying more than one baby; or you have been given other medicines that make the womb contract (e.g., oxytocin).
Medical Conditions to Discuss
Tell your doctor if you have: heart, liver or kidney problems; asthma; epilepsy; glaucoma (high pressure in the eye); if your membranes have ruptured (water has broken); if you are over 35 years of age; if you are over 40 weeks pregnant; or any allergies to medicines or other substances.
Pregnancy and Breastfeeding
Talk to your doctor if you are breastfeeding or intend to breastfeed, as this medication is specifically used during pregnancy for labor induction.
Drug Interactions
Some medicines may interfere with Prostin E2 and affect how it works. Always tell your healthcare team about all medicines you are taking.
- oxytocics (medicines used to make the muscles of your womb contract or bring on labor)
Storage
Prostin E2 Vaginal Gel will be stored in the pharmacy or on the hospital ward by healthcare professionals.
Overdose Information
Since Prostin E2 is administered by healthcare professionals in a controlled medical setting, overdose is unlikely. However, if you experience excessive pain or feel unwell after receiving the medication, tell your doctor or midwife immediately.
Frequently Asked Questions
Prostin E2 works by softening and opening the cervix and stimulating contractions to start labor. The timing can vary for each woman, and you will be closely monitored throughout the process.
Yes, you must stay lying down for at least 30 minutes after receiving the gel. During this time and throughout treatment, your contractions and your baby’s heart rate will be closely monitored.
You should not receive Prostin E2 if you have given birth 5 or more times or have had previous surgery involving the womb. Your doctor will assess your individual situation.
Tell your doctor or midwife immediately if you feel unwell or experience excessive pain after receiving Prostin E2. You should also report any concerning symptoms like excessive contractions or bleeding.
No, Prostin E2 should not be used if you are carrying more than one baby (multiple pregnancy).
You should tell your doctor if your membranes have ruptured (water has broken) as this is an important factor they need to consider before using Prostin E2.
Inform your doctor or midwife immediately if you notice sudden signs of allergy including shortness of breath, wheezing, swelling of face/lips/tongue, rash, itching or hives on the skin.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.