Opsumit (Macitentan)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Opsumit Used For?
Opsumit is a medication that helps manage pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries that supply blood to the lungs.
Primary Uses
Opsumit is primarily used to treat pulmonary arterial hypertension (PAH), which causes the pulmonary arteries to narrow, making it harder for the heart to pump blood.
How It Works
Opsumit works by widening the pulmonary arteries, thereby reducing blood pressure and alleviating symptoms associated with PAH.
Good to know: Opsumit is not considered addictive.
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How to Take Opsumit
Opsumit should be taken as directed by your healthcare provider, typically once daily.
Dosage Instructions
For adults, the recommended dose is one 10 mg film-coated tablet daily. For children over 2 years, the dose is based on body weight, with children weighing 40 kg or more able to use the 10 mg tablet.
What If You Miss a Dose?
If you miss a dose of Opsumit, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.
Important: Never double the dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- anemia (low red blood cell count)
- swelling due to fluid retention
- infections of the nose or throat
Seek immediate medical attention if you experience:
- severe allergic reactions
- signs of pulmonary edema such as sudden breathlessness
Important Warnings
There are several important warnings associated with Opsumit that patients should be aware of.
Who Should Not Take Opsumit
Do not take Opsumit if you are allergic to macitentan, soya, or any other ingredients in the medication. It is also contraindicated in pregnant individuals or those planning to become pregnant.
Medical Conditions to Discuss
Discuss any history of liver disease, kidney problems, pulmonary veno-occlusive disease, or low blood pressure with your doctor before starting Opsumit.
Pregnancy and Breastfeeding
Opsumit may cause birth defects. Do not take it if you are pregnant or planning to become pregnant. Women of childbearing potential must use reliable contraception during treatment and for 3 months after stopping.
Elderly Patients With Dementia: Caution is advised when prescribing Opsumit to elderly patients, particularly those with dementia.
Drug Interactions
Certain medications can interact with Opsumit and affect its efficacy.
Grapefruit interaction: Grapefruit may interact with Opsumit, so consult your doctor.
- rifampicin
- clarithromycin
- ciprofloxacin
- erythromycin
- ritonavir
- ketoconazole
- itraconazole
- voriconazole
- fluconazole
- miconazole
- phenytoin
- carbamazepine
- amiodarone
- ciclosporin
- diltiazem
- verapamil
- St. John’s Wort
- piperine
Alcohol & Driving
Be cautious when consuming alcohol or driving while taking Opsumit.
Alcohol
Limit alcohol intake as it may exacerbate side effects.
Driving and Operating Machinery
Be careful when driving or using machinery until you know how Opsumit affects you.
Storage
Store Opsumit in its original packaging in a cool, dry place below 30°C, away from moisture and heat.
Overdose Information
If you suspect an overdose of Opsumit, seek immediate medical attention. Contact your doctor or the Poisons Information Centre.
Frequently Asked Questions
The time it takes for Opsumit to show effects can vary by individual, but it is important to take it consistently as prescribed.
Opsumit can be taken with or without food.
No, Opsumit is not considered addictive.
Do not stop taking Opsumit without consulting your doctor, as it is important for managing your condition.
It is advisable to limit alcohol consumption while taking Opsumit.
Weight gain is not specifically mentioned as a side effect of Opsumit.
Elderly patients should use caution when taking Opsumit, especially those with dementia.
If you miss a dose, skip it and take the next dose at the scheduled time. Do not take a double dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.