Ocrevus (Ocrelizumab)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Ocrevus Used For?
Ocrevus is a medication that contains the active ingredient ocrelizumab, designed to help manage multiple sclerosis.
Primary Uses
It is primarily used to treat patients with relapsing forms of multiple sclerosis and primary progressive multiple sclerosis.
How It Works
Ocrevus targets specific B-cells in the immune system, reducing inflammation and attacks on the nervous system, which may decrease flare-ups and slow the progression of the disease.
Good to know: Ocrevus is not considered addictive.
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How to Take Ocrevus
Ocrevus is given either as an intravenous infusion or a subcutaneous injection, administered by a healthcare professional.
Dosage Instructions
For intravenous use, the initial dose is 600 mg given as two infusions of 300 mg each, two weeks apart. Subsequent doses of 600 mg are given every six months. For subcutaneous use, the initial dose is 920 mg, followed by 920 mg every six months if well tolerated.
What If You Miss a Dose?
If you miss an appointment for your treatment, reschedule as soon as possible. Do not wait for the next scheduled dose.
Important: Never double the dose if you miss an appointment.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Infusion-related reactions
- Injection reactions
- Infections such as respiratory tract infections and sinusitis
Seek immediate medical attention if you experience:
- Allergic reactions including swelling of the face, lips, or throat
- Severe infections
- Stomach and bowel problems such as persistent diarrhea
- Liver problems indicated by fatigue, loss of appetite, or yellowing of the skin
Important Warnings
There are several important considerations to keep in mind before using Ocrevus.
Who Should Not Take Ocrevus
Do not use Ocrevus if you are allergic to ocrelizumab or any of its ingredients, have an active infection, have a severely weakened immune system, or have any type of cancer.
Medical Conditions to Discuss
Discuss any history of infections, particularly hepatitis B, and any other medical conditions with your doctor before starting Ocrevus.
Pregnancy and Breastfeeding
Use effective contraception during treatment and for at least four months after the last dose. Avoid Ocrevus during pregnancy unless directed by your doctor. If breastfeeding, consult your doctor; Ocrevus may pass into breast milk.
Drug Interactions
Ocrevus may interact with other medications, affecting how they work.
- Live vaccines should not be administered while receiving Ocrevus and for several months after.
- Other treatments that affect the immune system may increase the risk of side effects.
- Medications that lower blood pressure may need to be adjusted while using Ocrevus.
Alcohol & Driving
Be cautious with alcohol consumption and operating vehicles or machinery while on Ocrevus.
Alcohol
Consult your doctor regarding alcohol use while taking Ocrevus.
Driving and Operating Machinery
It is not known if Ocrevus affects your ability to drive or operate machinery; exercise caution.
Storage
Store Ocrevus in a refrigerator between 2°C and 8°C. Do not freeze. Keep it in the original carton to protect it from light and out of reach of children.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or go to the nearest emergency department.
Frequently Asked Questions
Ocrevus may take time to show effects; discuss expected timelines with your healthcare provider.
There are no specific dietary restrictions mentioned for Ocrevus.
No, Ocrevus is not considered addictive.
Do not stop taking Ocrevus without consulting your doctor, as it may worsen your condition.
Consult your doctor regarding alcohol consumption while on Ocrevus.
Weight gain is not listed as a common side effect of Ocrevus.
Consult your healthcare provider for specific guidance regarding elderly patients and Ocrevus.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.