Noxafil (Posaconazole)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Noxafil Used For?
Noxafil is an antifungal medication that helps to eliminate or inhibit the growth of fungi responsible for infections.
Primary Uses
Noxafil is primarily used to treat invasive aspergillosis, fusariosis, zygomycosis, chromoblastomycosis, mycetoma, and oropharyngeal candidiasis. It is also used to prevent fungal infections in high-risk patients.
How It Works
Noxafil works by disrupting the cell membrane of fungi, thereby stopping their growth and replication.
Good to know: Noxafil is not considered addictive.
Continue Reading
Sign in to access the complete medication guide including dosage, side effects, warnings, and more.
How to Take Noxafil
Follow your doctor's instructions carefully when taking Noxafil.
Dosage Instructions
For invasive fungal infections, the usual adult dose is 10 mL of oral suspension twice daily or three modified release tablets twice on the first day, then once daily thereafter. For oropharyngeal candidiasis, take 5 mL on the first day, then 2.5 mL daily for 13 days. For prevention, take 5 mL three times daily.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Important: Never double dose to make up for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- loss of appetite
- upset stomach
- nausea
- vomiting
- stomach pain
- diarrhoea
- gas
- dry mouth
- altered sense of taste
- sleeplessness
- headache
- dizziness
- sleepiness
- tingling in fingers or toes
- hot flushes
- dry skin
- rash
- itchiness
- back pain
- fever
Seek immediate medical attention if you experience:
- rash
- itchiness
- hives
- swelling of the face, lips, mouth, throat, or neck
- tingling or numbness of hands or feet
- muscle weakness
Important Warnings
There are specific warnings to consider before using Noxafil.
Who Should Not Take Noxafil
Do not use Noxafil if you are allergic to posaconazole or any other triazole antifungal medications.
Medical Conditions to Discuss
Inform your doctor if you have kidney, liver, or heart problems, or issues with potassium, magnesium, or calcium levels.
Pregnancy and Breastfeeding
Noxafil should not be taken during pregnancy unless prescribed. Effective contraception is advised during treatment and for two weeks after. It is also not recommended for breastfeeding women.
Drug Interactions
Certain medications may interact with Noxafil, affecting its efficacy or increasing side effects.
- terfenadine
- astemizole
- cisapride
- pimozide
- quinidine
- ergotamine
- dihydroergotamine
- halofantrine
- simvastatin
- lovastatin
- atorvastatin
- rivaroxaban
- apixaban
- rifabutin
- phenytoin
- efavirenz
- fosamprenavir
- cimetidine
- ranitidine
- omeprazole
- vincristine
- vinblastine
- cyclosporine
- tacrolimus
- sirolimus
- midazolam
- calcium channel blockers
- digoxin
- sulfonylureas
- protease inhibitors
- venetoclax
Alcohol & Driving
Be cautious when consuming alcohol or operating machinery while on Noxafil.
Alcohol
Consult your doctor regarding alcohol consumption while taking Noxafil.
Driving and Operating Machinery
Noxafil may cause dizziness or blurred vision, so avoid driving or using heavy machinery until you know how it affects you.
Storage
Store Noxafil Oral Suspension below 25°C and Modified Release Tablets below 30°C. Keep out of reach of children and do not store in the bathroom.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26 in Australia.
Frequently Asked Questions
The time it takes for Noxafil to work can vary based on the type of infection being treated.
Yes, taking Noxafil with a meal or nutritional supplement can improve absorption.
No, Noxafil is not considered addictive.
Consult your doctor before stopping Noxafil, as it is important to complete the prescribed course.
It is advisable to consult your doctor regarding alcohol consumption while on Noxafil.
Weight gain is not listed as a common side effect of Noxafil.
Elderly patients should discuss potential risks with their doctor before taking Noxafil.
Take the missed dose as soon as you remember, but skip it if it's almost time for your next dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.