Ebglyss (Lebrikizumab)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Ebglyss Used For?
Ebglyss is a prescription medication that helps treat moderate to severe atopic dermatitis, also known as atopic eczema, in adults and adolescents 12 years and older.
Primary Uses
Ebglyss is used to treat moderate to severe atopic dermatitis (atopic eczema) in adult and adolescent patients who are 12 years of age and older.
How It Works
Ebglyss belongs to a group of medicines called monoclonal antibodies. It works by blocking a specific protein called interleukin-13 (IL-13), which contributes to inflammation and plays a role in atopic dermatitis.
How to Take Ebglyss
Ebglyss is given as an injection under your skin using a pre-filled autoinjector pen. Your doctor will show you or your caregiver how to inject it properly.
Dosage Instructions
Starting dose: Two 250 mg injections at Week 0, then two 250 mg injections at Week 2, then one 250 mg injection every 2 weeks from Week 4 to Week 16. Maintenance dose: From Week 16 onwards, one 250 mg injection every 4 weeks if you respond well to treatment. If response is inadequate, your doctor may continue every 2 weeks until Week 24. Remove from refrigerator at least 45 minutes before injection. Inject into stomach area (at least 5 cm from belly button) or front of thigh (at least 5 cm above knee and below groin). Change injection sites each time.
What If You Miss a Dose?
If you miss your dose at the usual time, inject the missed dose as soon as possible. Then take your next dose at your regular scheduled time. If you have questions about your schedule, ask your doctor or pharmacist.
Important: Use each autoinjector pen for single use only. Do not inject in areas where skin is tender, bruised, red, hard, or affected by eczema.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Injection site reactions (redness, swelling, itching)
- Eye infection
- Dry eyes
- Eye pain
- Blurry vision
- Sensitivity to light
- Eye and eyelid inflammation (redness, swelling, itching)
- Redness of eyes
- Itchy and watery eyes
Seek immediate medical attention if you experience:
- Breathing problems or wheezing
- Swelling of face, lips, mouth, tongue, or throat
- Hives
- Fainting, dizziness, feeling lightheaded
- Skin rash
- Stomach cramps
- Shingles symptoms (headache, sensitivity to light, tingling, painful skin rash with blisters)
- Increase in white blood cell count
Important Warnings
There are important safety considerations before starting Ebglyss treatment that you should discuss with your doctor.
Who Should Not Take Ebglyss
Do not use Ebglyss if you are allergic to lebrikizumab or any ingredients in the medication. Do not use in children under 12 years or adolescents (12-18 years) weighing less than 40 kg. Do not use if the medicine is cloudy, discolored, contains particles, is past expiration date, or appears damaged.
Medical Conditions to Discuss
Tell your doctor if you have a parasitic (helminth) infection, any eye problems such as eye pain or vision changes, or if you take topical or inhaled corticosteroid medicines. Make sure you are up to date with all vaccinations before starting treatment.
Pregnancy and Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant. The effects in pregnant women are not known, so avoid use during pregnancy unless your doctor advises otherwise. If breastfeeding or planning to breastfeed, discuss with your doctor as it’s unknown if Ebglyss passes into breast milk. You should not both breastfeed and use Ebglyss.
Vaccination Warning: You should not receive live vaccines while taking Ebglyss. Tell your doctor about any planned vaccinations.
Drug Interactions
Some medicines and vaccines may interfere with Ebglyss. Always tell your healthcare providers about all medications you’re taking.
- Live vaccines
- Other medicines (consult doctor)
- Vitamins and supplements
Alcohol & Driving
Ebglyss is unlikely to affect your ability to drive or operate machinery.
Driving and Operating Machinery
Ebglyss is unlikely to influence your ability to drive or use machines.
Storage
Store Ebglyss in the refrigerator at 2°C to 8°C in the original carton to protect from light. Do not freeze or expose to excessive heat above 30°C. Do not shake. If needed, Ebglyss can be kept at room temperature up to 30°C for a maximum of 7 days, but once removed from refrigeration, do not put it back in the refrigerator. Dispose of used autoinjectors in a sharps disposal container immediately after use.
Overdose Information
If you think you have used too much Ebglyss, you may need urgent medical attention. Immediately phone the Poisons Information Centre (13 11 26), contact your doctor, or go to the Emergency Department at your nearest hospital, even if there are no signs of discomfort.
Frequently Asked Questions
Your doctor will assess your response to Ebglyss at Week 16. If you have an adequate response, you may switch to maintenance dosing every 4 weeks. If response is inadequate, your doctor may continue treatment every 2 weeks until Week 24.
Yes, adult patients can self-administer the injection after proper training. For adolescents under 18, an adult should give the injection after training in proper injection technique.
If you miss your dose, inject it as soon as possible, then take your next dose at your regular scheduled time. Contact your doctor or pharmacist if you have questions about your schedule.
Make sure you are up to date with all vaccinations before starting Ebglyss. You should not receive live vaccines while taking Ebglyss. Tell your doctor about any planned vaccinations.
Inject into your stomach area (at least 5 cm from belly button) or front of thigh (at least 5 cm above knee and below groin). You can also use the back of your upper arm if someone else is giving the injection. Change injection sites each time.
Do not use Ebglyss if it appears cloudy, discolored, contains visible particles, is past its expiration date, or if you think it has been frozen or exposed to excessive heat. Contact your pharmacist for a replacement.
Ebglyss should be stored refrigerated at 2°C to 8°C, but can be kept at room temperature up to 30°C for a maximum of 7 days if needed. Once removed from refrigeration, do not put it back in the refrigerator.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.