Alunbrig (Brigatinib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Alunbrig Used For?
Alunbrig is a medication that contains brigatinib, which is used to treat adults diagnosed with non-small cell lung cancer (NSCLC).
Primary Uses
It is specifically used for patients whose cancer is ALK-positive and has advanced or metastasized.
How It Works
Alunbrig works by inhibiting the activity of the ALK protein, which is involved in the growth and spread of cancer cells.
Good to know: Alunbrig is not considered addictive.
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How to Take Alunbrig
Alunbrig should be taken as directed by your healthcare provider.
Dosage Instructions
The typical starting dose is one 90 mg tablet daily for the first 7 days, followed by one 180 mg tablet daily. Swallow the tablets whole with a full glass of water, and do not crush or dissolve them.
What If You Miss a Dose?
If you miss a dose, skip it and take your next dose at the regular time. Do not take a double dose.
Important: Never double dose to make up for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- tiredness
- headaches
- shortness of breath during exercise
- dizziness
- pale appearance
- increased urination
- excessive thirst
- dry mouth
- difficulty sleeping
- numbness or weakness in arms and legs
- tingling or prickling sensations
- blurred or impaired vision
- high blood pressure
- abdominal pain
- nausea
- vomiting
- diarrhea
- constipation
- rash
- itching
- joint pain and swelling
- general body swelling
- fever
- decreased appetite or weight loss
- cold-like symptoms
- sensitivity to sunlight
Seek immediate medical attention if you experience:
- lung or breathing problems including shortness of breath or difficulty breathing
- slow heartbeat (bradycardia)
- new or worsening muscle pain or weakness
Important Warnings
There are several important considerations to keep in mind while taking Alunbrig.
Who Should Not Take Alunbrig
Do not take Alunbrig if you are allergic to brigatinib or any of its ingredients, are under 18 years old, or if the medication is expired or the packaging is damaged.
Medical Conditions to Discuss
Discuss any history of lung or breathing problems, high blood pressure, slow heartbeat, vision issues, muscle pain, or liver and kidney problems with your doctor.
Pregnancy and Breastfeeding
Alunbrig may harm an unborn baby; do not use it if you are pregnant or planning to become pregnant. Effective contraception is advised during treatment and for several months after. It is not recommended to breastfeed while taking Alunbrig.
Drug Interactions
Certain medications may interact with Alunbrig and affect its efficacy.
Grapefruit interaction: Avoid grapefruit products during treatment as they may alter the effectiveness of Alunbrig.
- ketoconazole
- itraconazole
- voriconazole
- indinavir
- nelfinavir
- ritonavir
- saquinavir
- clarithromycin
- telithromycin
- troleandomycin
- St. John's wort
- carbamazepine
- phenobarbital
- phenytoin
- rifabutin
- rifampicin
- digoxin
- dabigatran
- colchicine
- pravastatin
- rosuvastatin
- methotrexate
- sulfasalazine
- efavirenz
- etravirine
- modafinil
- diltiazem
- verapamil
- bosentan
Alcohol & Driving
Be cautious with alcohol consumption and operating vehicles or machinery while on Alunbrig.
Alcohol
Consult your doctor regarding alcohol use while taking Alunbrig.
Driving and Operating Machinery
Be careful when driving or using machinery until you know how Alunbrig affects you. Avoid these activities if you experience dizziness or visual disturbances.
Storage
Store Alunbrig in a cool, dry place below 30°C. Keep it in its original packaging and out of reach of children.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact the Poisons Information Centre at 13 11 26 or go to the nearest hospital.
Frequently Asked Questions
The time it takes for Alunbrig to show effects can vary by individual.
Alunbrig can be taken with or without food.
No, Alunbrig is not considered addictive.
Do not stop taking Alunbrig without consulting your doctor.
Consult your doctor regarding alcohol consumption while on Alunbrig.
Weight gain is not listed as a common side effect of Alunbrig.
Consult your doctor for specific guidance regarding elderly patients.
If you miss a dose, skip it and take your next dose at the regular time. Do not double dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.