Nexium Hp7 (Esomeprazole, Amoxicillin Trihydrate, Clarithromycin)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Nexium Hp7 Used For?
Nexium Hp7 is a combination pack containing three different medicines that work together to treat peptic ulcers caused by Helicobacter pylori bacteria in your stomach.
Primary Uses
Nexium Hp7 is used to kill Helicobacter pylori bacteria in your stomach and allow peptic ulcers to heal. These ulcers can occur in your stomach (gastric ulcer) or in the duodenum, which is the tube leading out from your stomach (duodenal ulcer). Most people with peptic ulcers have this bacteria in their stomach, and killing it prevents the ulcer from returning.
How It Works
The combination contains three medicines: NEXIUM (esomeprazole) is a proton-pump inhibitor that reduces stomach acid to provide symptom relief and allow healing. AMOXIL (amoxicillin trihydrate) and KLACID (clarithromycin) are antibiotics that help kill Helicobacter pylori bacteria. NEXIUM also helps kill the bacteria. When all three are taken together, they are more effective than taking one or two at a time.
Good to know: There is no evidence that NEXIUM Hp7 is addictive.
How to Take Nexium Hp7
It is very important that you take NEXIUM Hp7 exactly as prescribed. The combination must be taken in specific doses twice daily to be effective.
Dosage Instructions
Take the following doses twice daily (morning and night): NEXIUM: one 20 mg tablet, AMOXIL: two 500 mg capsules, KLACID: one 500 mg tablet. Take during or after meals at about the same time each day. Swallow NEXIUM tablets whole with water – do not crush or chew as they will not work properly. For swallowing difficulties, the tablet can be placed in half a glass of non-carbonated water, gently mixed without crushing, then drink and rinse the glass. Continue taking until you finish the complete course or your doctor tells you to stop.
What If You Miss a Dose?
If you miss any of the medicines at the usual time, take it as soon as you remember, as long as it is more than four hours before the next dose is due. If it has been more than 4 hours after you usually take your dose, skip that dose and take the next dose at your usual time.
Important: Do not take a double dose to make up for a missed dose. You must complete the full course for it to work properly – if you don’t, the bacteria may not clear completely and your symptoms may return.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Diarrhea, nausea or vomiting
- Headache
- Dizziness
- Constipation
- Loss of appetite
- Stomach pain or cramps
- Gas (wind)
- Dry mouth or other body cavities
- Sore mouth, throat or tongue
- Pins and needles sensation
- Metallic taste or changes in taste or smell
- Chills
- Fatigue
- Excessive burping
Seek immediate medical attention if you experience:
- Muscle pain or weakness
- Increase in breast size (males)
- Fever
- Changes in sleep patterns
- Mood changes, hallucinations, confusion or depression
- Changes in sexual function
- Blurred vision, hearing disturbances
- Hair loss
- Bleeding or bruising more easily than normal
- Signs of frequent infections (fever, severe chills, sore throat, mouth ulcers)
- Skin rash
- Blood in urine
- Increased or decreased urine output
- Tremor
- Convulsions or fits
- Overgrowth of yeast infections (thrush)
- Fainting
- Yellowing of eyes or skin
- Muscle twitching or jerking movements
- Irregular (fast or slow) heartbeat
- Loss of consciousness
- Red rash on buttocks, upper inner thighs, armpits, neck
- Shortness of breath, wheezing or difficulty breathing
- Swelling of face, lips, tongue or other body parts
- Chest pain
- Severe skin reaction with rash, itching, redness, blistering or peeling, possibly with high fever and joint pains
- Severe upper stomach pain with nausea and vomiting
- Signs of liver inflammation (yellowing of skin or eyes, feeling unwell, nausea, vomiting, loss of appetite)
- Skin reaction in sun-exposed areas with joint pain
- Headache, increased light sensitivity, neck stiffness, unsteadiness, fits
- Severe stomach cramps, watery and severe diarrhea (possibly bloody, may occur weeks after stopping treatment)
Important Warnings
Before taking Nexium Hp7, it’s important to discuss your medical history and current medications with your doctor to ensure it’s safe for you.
Who Should Not Take Nexium Hp7
Do not use if you are allergic to esomeprazole, amoxicillin trihydrate, clarithromycin, or any ingredients listed. Do not use if allergic to proton-pump inhibitors, penicillins, cephalosporins, or macrolide antibiotics. Do not take if you have heart conditions such as QT prolongation or ventricular cardiac arrhythmia, low magnesium or potassium levels, or both liver and kidney problems. Do not take with certain medicines including ergotamine, dihydroergotamine, cisapride, pimozide, astemizole, terfenadine, cilostazol, atazanavir, colchicine, simvastatin, lovastatin, ticagrelor, ranolazine, oral midazolam, domperidone, lomitapide, or ivabradine.
Medical Conditions to Discuss
Tell your doctor if you have allergies to medicines, foods, dyes or preservatives; blood problems; liver or kidney problems; heart conditions; glandular fever; myasthenia gravis (muscle weakness condition); osteoporosis; low potassium, magnesium or other electrolyte imbalances; or have had skin reactions to similar stomach acid-reducing medicines.
Pregnancy and Breastfeeding
Check with your doctor if you are pregnant or planning to become pregnant. It is not known if Nexium Hp7 is safe during pregnancy, and the medicines may affect the developing baby. Talk to your doctor if breastfeeding or planning to breastfeed, as your baby can receive all the medicines through breast milk. Nexium Hp7 is not recommended when breastfeeding.
Children: NEXIUM Hp7 is not recommended for use in children as there is no information about its use in children.
Drug Interactions
Many medicines can interact with Nexium Hp7, affecting how well it works or increasing the risk of side effects. Always tell your doctor about all medicines you’re taking.
- Sedatives: diazepam, triazolam, alprazolam
- Antifungals: ketoconazole, itraconazole, voriconazole, fluconazole
- Blood thinners: warfarin, apixaban, rivaroxaban, dabigatran, clopidogrel, edoxaban
- Gout medicines: allopurinol, probenecid
- Seizure medicines: phenytoin, sodium valproate, carbamazepine
- Cholesterol medicines: atorvastatin, rosuvastatin
- Asthma medicine: theophylline
- HIV medicines: zidovudine, saquinavir, efavirenz, etravirine, nevirapine, nelfinavir, ritonavir
- Diabetes medicines: insulin, repaglinide, nateglinide, pioglitazone, rosiglitazone
- Heart medicines: digoxin, quinidine, disopyramide
- Antidepressants: citalopram, fluoxetine, clomipramine, imipramine
- St John’s wort
- Antibiotics: rifabutin, rifapentine, rifampicin, erythromycin, tetracycline, aminoglycosides
- Erectile dysfunction medicines: sildenafil, tadalafil, vardenafil
- Incontinence medicine: tolterodine
- Blood pressure medicines: verapamil, amlodipine, diltiazem
- Corticosteroids: methylprednisolone
- Birth control pills
- Immunosuppressants: tacrolimus, ciclosporin
- Cancer medicines: methotrexate, erlotinib, vinblastine, ibrutinib
- Epilepsy medicine: phenobarbital
- Antipsychotics: quetiapine
- Antimalarials: hydroxychloroquine, chloroquine
Alcohol & Driving
Nexium Hp7 may affect your ability to drive or operate machinery safely.
Alcohol
No specific alcohol warnings are mentioned in the prescribing information. However, always consult your doctor about alcohol consumption while taking any medication.
Driving and Operating Machinery
Be careful before you drive or use any machines or tools until you know how Nexium Hp7 affects you. The medication may cause dizziness in some people. Make sure you know how you react to Nexium Hp7 before doing anything that may be dangerous if you are dizzy.
Temperature Regulation
No specific temperature regulation warnings are mentioned in the prescribing information.
Storage
Keep the three medicines in Nexium Hp7 in their separate blisters until it is time to take them. Store in a cool dry place where the temperature stays below 25°C. Do not store in the bathroom, near a sink, in the car, or on window sills, as heat and dampness can destroy some medicines. Keep where young children cannot reach it – a locked cupboard at least one-and-a-half metres above the ground is recommended. Take any unwanted or expired medicine to any pharmacy for safe disposal.
Overdose Information
If you think you have used too much Nexium Hp7, you may need urgent medical attention. Immediately phone the Poisons Information Centre (13 11 26), contact your doctor, or go to the Emergency Department at your nearest hospital. Do this even if there are no signs of discomfort or poisoning. Taking too much Nexium Hp7 may cause vomiting and severe stomach problems.
Frequently Asked Questions
Nexium Hp7 works by killing Helicobacter pylori bacteria and allowing your peptic ulcer to heal. You must complete the full course as prescribed by your doctor for it to be effective. The exact timeframe varies, but it’s important to take all the capsules and tablets in the pack for it to work properly.
Yes, you should take Nexium Hp7 during or after meals. Taking it at about the same time each day with meals will help you remember to take it and may help reduce stomach upset.
No, there is no evidence that Nexium Hp7 is addictive.
Do not stop taking Nexium Hp7 or change any of the doses unless your doctor tells you to. You need to take all the capsules and tablets in the pack for it to work properly. If you stop taking it early, the Helicobacter pylori bacteria may not clear completely, your ulcer may come back, and it may be harder to treat next time.
The prescribing information does not mention specific alcohol restrictions, but you should always consult your doctor about alcohol consumption while taking any medication, especially when taking multiple medicines like in this combination pack.
If you miss any of the medicines at the usual time, take it as soon as you remember, as long as it is more than four hours before the next dose is due. If it has been more than 4 hours after you usually take your dose, skip that dose and take the next dose at your usual time. Never take a double dose to make up for a missed dose.
No, do not crush or chew the NEXIUM tablets as they will not work properly. Swallow them whole with a glass of water. If you have difficulty swallowing, the tablet can be placed in half a glass of non-carbonated water, gently mixed without crushing, then drink the mixture and rinse the glass with more water.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.