Mayzent (Siponimod)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Mayzent Used For?
Mayzent contains siponimod and belongs to a group of medicines called sphingosine-1-phosphate (S1P) receptor modulators. It helps slow down the effects of multiple sclerosis by reducing nerve damage and potentially extending time without relapses.
Primary Uses
Mayzent is used for treating adult patients with secondary progressive multiple sclerosis (SPMS).
How It Works
Mayzent helps slow down MS effects such as worsening disability and decline in thinking. It may also slow down nerve damage caused by MS and increase your time without relapse.
How to Take Mayzent
Your Mayzent treatment begins with a special 5-day starter pack to gradually increase your dose, followed by your regular daily dose.
Dosage Instructions
Start with a 5-day titration pack: Day 1-2: 0.25mg (1 tablet), Day 3: 0.5mg (2 tablets), Day 4: 0.75mg (3 tablets), Day 5: 1.25mg (5 tablets). From Day 6 onwards: usual dose is 2mg once daily. Some patients with specific genotypes (CYP2C9 *2*3 or CYP2C9 *1*3) take 1mg once daily. Take at the same time each day with or without food, swallowed with half a glass of water.
What If You Miss a Dose?
Take the missed dose as soon as you remember, then continue with your regular schedule. If it’s almost time for your next dose, skip the missed dose. If you miss a dose during the first 6 days of treatment, contact your doctor – you may need to restart with a new starter pack. If you stop taking Mayzent for 4 or more days, you’ll need to restart with the starter pack.
Important: Never take a double dose to make up for a missed dose. Do not stop taking Mayzent suddenly without talking to your doctor.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Headache
- Dizziness
- Diarrhea
- Feeling unwell
- Pain in legs or arms
- Swollen hands, ankles, legs or feet
- Weakness
- Skin changes (small spots or lumps of various colors)
Seek immediate medical attention if you experience:
- Infections (shingles, fever, sore throat, mouth ulcers)
- Fungal or viral infections with headache, stiff neck, light sensitivity
- Brain infection signs (weakness, visual changes, memory loss, thinking problems, walking difficulty)
- Heart problems (slow or irregular heartbeat)
- Skin cancer (new bumps, patches, moles, or changes to existing moles)
- Worsening MS symptoms (muscle weakness, eye changes, tremor)
- Difficulty breathing
- Convulsions or uncontrolled shaking
- Vision problems or trouble seeing colors
- Liver problems (nausea, vomiting, abdominal pain, yellowing of skin/eyes, dark urine)
Important Warnings
Before starting Mayzent, your doctor needs to check several things about your health and run specific tests.
Who Should Not Take Mayzent
Do not use if you: are allergic to siponimod or any ingredients; have CYP2C9 *3*3 genotype; had a heart attack, angina, stroke, or certain heart failure in the last 6 months; have irregular heartbeat without a pacemaker.
Medical Conditions to Discuss
Tell your doctor if you have: infections or lowered immune system; haven’t had chickenpox or vaccination; eye or vision problems; uncontrolled high blood pressure; slow heartbeat or take heart-slowing medicines; severe breathing problems or asthma; liver problems; any other medical conditions.
Pregnancy and Breastfeeding
Avoid becoming pregnant while using Mayzent and for 10 days after stopping. Use effective birth control. Do not take Mayzent while breastfeeding. Tell your doctor immediately if you become pregnant.
Required Tests: You must have blood tests to check your genotype and complete blood count, plus an eye examination before starting Mayzent.
Drug Interactions
Several types of medicines can interfere with Mayzent and affect how it works.
- Medicines for irregular heartbeat (quinidine, procainamide, amiodarone, sotalol)
- Medicines that slow heartbeat (verapamil, diltiazem, ivabradine, digoxin)
- Immune system medicines (other MS treatments, corticosteroids)
- Live attenuated vaccines
- Carbamazepine
- Modafinil and fluconazole (for certain genotypes)
Alcohol & Driving
Be aware of how Mayzent may affect your daily activities and take appropriate precautions.
Alcohol
There are no known interactions between Mayzent and alcohol.
Driving and Operating Machinery
Be careful before driving or using machines until you know how Mayzent affects you. Mayzent may cause dizziness in some people.
Storage
Store tablets in refrigerator between 2°C-8°C. Do not freeze. After opening, only 1mg and 2mg tablets can be stored below 30°C for up to 3 months in a cool, dry place. Keep in original package and out of reach of children.
Overdose Information
If you think you have taken too much Mayzent, seek urgent medical attention immediately. Call the Poisons Information Centre (13 11 26), contact your doctor, or go to the nearest hospital Emergency Department, even if you feel fine.
Frequently Asked Questions
The starter pack lasts for 5 days, with gradually increasing doses each day. You start your regular dose on Day 6.
Yes, you can take Mayzent with or without food. Swallow the tablets with half a glass of water.
Do not stop taking Mayzent suddenly. If you stop, your multiple sclerosis symptoms can return and may become worse than before treatment. Always talk to your doctor before stopping.
There are no known interactions between Mayzent and alcohol according to the medication information.
Take the missed dose as soon as you remember, then take your next dose as usual. If it’s almost time for your next dose, skip the missed one. Never take a double dose. If you miss doses during the first 6 days, contact your doctor.
Yes, you need regular eye check-ups, skin checks, and should protect your skin from sun exposure. Your doctor may also do blood tests to monitor your progress.
Tell your doctor if you plan to receive a vaccine. You should not receive live attenuated vaccines during treatment and for up to 4 weeks after stopping Mayzent.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.