Feiba-NF (Factor Viii Inhibitor Bypassing Fraction)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Feiba-NF Used For?
Feiba-NF is a specialized blood clotting medication designed for people with hemophilia A or B who have developed antibodies (inhibitors) against standard clotting factors.
Primary Uses
Feiba-NF is used to treat bleeding episodes in hemophilia A or B patients with inhibitors, prevent bleeding episodes in these patients, and prevent or reduce bleeding before, during and after surgery in hemophilia A or B patients with inhibitors.
How It Works
Feiba-NF contains blood factors that can bypass the effects of antibodies that interfere with normal clotting factors. This allows your blood to clot properly even when your body has developed resistance to standard hemophilia treatments.
Good to know: This medicine helps control your condition but does not cure it. It provides an alternative pathway for blood clotting when standard treatments are blocked by inhibitors.
How to Take Feiba-NF
Feiba-NF is given as a slow injection directly into your vein by a qualified healthcare professional experienced in hemophilia care. Some patients may be trained for home administration.
Dosage Instructions
Your dose depends on your body weight and bleeding severity. A typical dose is 50 to 100 Units per kilogram of body weight (U/kg). The maximum single dose should not exceed 100 U/kg, and the maximum daily dose should not exceed 200 U/kg. The medicine comes as a powder that must be mixed with the provided diluent before use.
What If You Miss a Dose?
If you miss a scheduled injection, do not take a double dose to make up for the missed dose. Contact your doctor or Hemophilia Treatment Centre for guidance on what to do next.
Important: Never inject a double dose as this may increase your chance of getting serious side effects. Always record the name and batch number each time you use Feiba-NF.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Headache
- Dizziness
- Light-headedness
- Rash
- Allergies
- Hepatitis B surface antibody positive (shown in blood tests)
Seek immediate medical attention if you experience:
- Disseminated intravascular coagulation (blood clotting condition causing blood clots, bleeding and sudden bruising)
- Blood clots in veins or lungs
- Heart attack
- Stroke
- Severe sudden allergic reaction with difficulty breathing, chest pain and fainting
- Signs of severe allergic reaction: rash, hives, swelling of face/lips/tongue, shortness of breath, chest tightness, dizziness and fainting
Important Warnings
There are important safety considerations and medical conditions that may affect whether Feiba-NF is right for you.
Who Should Not Take Feiba-NF
Do not use Feiba-NF if you are allergic to factor VIII inhibitor bypassing fraction or any ingredients in the medicine, or if you have Disseminated Intravascular Coagulation (a blood clotting condition that causes blood clots, bleeding and sudden bruising).
Medical Conditions to Discuss
Tell your doctor if you have suffered from a heart attack, have a blood clot, have liver problems, have an immune system that is not working properly, or have any other medical conditions. If you are taking emicizumab, it is very important to discuss this with your doctor before using Feiba-NF.
Pregnancy and Breastfeeding
There is no information on the use of Feiba-NF during pregnancy. It is not known if Feiba-NF passes into breast milk. Your doctor will discuss the risks and benefits if you are pregnant or breastfeeding.
Emicizumab Interaction: If you are taking emicizumab before or while using Feiba-NF, seek urgent medical attention if you notice symptoms of blood clots or thrombotic microangiopathy.
Drug Interactions
Some medicines may interfere with Feiba-NF and affect how it works. Always tell your healthcare team about all medicines you are taking.
Important monitoring: If you are taking any of these medicines while receiving Feiba-NF, your doctor will need to monitor you closely for serious side effects.
- Anti-fibrinolytics (aminocaproic acid, tranexamic acid)
- Recombinant activated factor VII
- Emicizumab (requires close monitoring for serious side effects)
Alcohol & Driving
Feiba-NF is not expected to affect your ability to drive or operate machinery, but you should be cautious until you know how it affects you.
Alcohol
No specific alcohol interactions are mentioned in the prescribing information. However, always consult your doctor about alcohol consumption while receiving treatment.
Driving and Operating Machinery
Be careful before you drive or use any machines or tools until you know how Feiba-NF affects you. The medication is not expected to impair your abilities, but side effects like dizziness could affect your performance.
Storage
Store Feiba-NF below 25°C and keep it in the original pack to protect from light. After mixing the powder with diluent, use the solution immediately or within 3 hours when stored at room temperature. Do not refrigerate the prepared solution. Keep out of reach of children.
Overdose Information
If you think you have used too much Feiba-NF, seek urgent medical attention immediately. Contact your doctor or Hemophilia Treatment Centre, go to the nearest hospital Emergency Department, or call the Poisons Information Centre (13 11 26 in Australia or 0800 764 766 in New Zealand). Do this even if you feel fine, as symptoms may not appear immediately.
Frequently Asked Questions
Feiba-NF works by providing an alternative pathway for blood clotting. The medication is designed to help control bleeding episodes, but the specific timing of effectiveness will depend on your individual condition and the severity of bleeding.
Some individuals may be trained to use Feiba-NF at home, but you should never attempt to inject it yourself unless you have received proper training from your doctor or Hemophilia Treatment Centre on how to use the product safely.
Tell your doctor or Hemophilia Treatment Centre immediately if Feiba-NF is no longer helping your condition, such as if you notice an increase in bleeding episodes. Your body can sometimes develop antibodies against the medication.
Feiba-NF comes as a powder that must be mixed with the water for injections provided in the pack. Use only the reconstitution device provided and follow the step-by-step instructions carefully. Use the solution immediately after mixing, or within 3 hours at room temperature.
If you forget your scheduled injection, do not inject a double dose to make up for the missed dose. Contact your doctor or Hemophilia Treatment Centre for guidance on what to do next.
There is no information available on the use of Feiba-NF during pregnancy. Your doctor will discuss the risks and benefits with you if you are pregnant or planning to become pregnant.
Usually, replacement therapy with Feiba-NF is a life-long treatment. Continue using it for as long as your doctor tells you, as it helps control your condition but does not cure it.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.