Maviret (Glecaprevir And Pibrentasvir)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Maviret Used For?
Maviret is a combination medication that contains two active ingredients: glecaprevir and pibrentasvir. It’s specifically designed to treat chronic hepatitis C infection.
Primary Uses
Maviret is used to treat chronic hepatitis C in patients 3 years and older. It’s effective against various types of hepatitis C virus.
How It Works
The medication combines two antiviral drugs that work together to stop the hepatitis C virus from multiplying in your body.
Good to know: This medicine is subject to additional monitoring to quickly identify new safety information, helping ensure your safety.
How to Take Maviret
Maviret comes in two forms: tablets for patients 12 years and older, and granules for children 3 to less than 12 years old. Both forms should be taken once daily with food.
Dosage Instructions
For patients 12 years and older: Take 3 tablets together once every day with food. Do not break, crush, or chew the tablets – swallow them whole with a full glass of water. For children 3 to less than 12 years: The doctor will prescribe the right dose based on your child’s weight. Mix the granules with a small amount (1-2 teaspoons) of recommended food like Greek yogurt, cream cheese, peanut butter, chocolate hazelnut spread, or thick jam. Give this mixture immediately without chewing, within 15 minutes of preparation.
What If You Miss a Dose?
If it’s less than 6 hours until your next dose, skip the missed dose. If it’s 6 hours or more until your next dose, take the missed dose and then take your next dose at the usual time. If vomiting occurs within 3 hours of taking your dose, take an additional dose. If vomiting occurs more than 3 hours after taking your dose, no additional dose is needed.
Important: Never take a double dose to make up for a missed dose. Always take Maviret at about the same time each day.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- feeling very tired or lacking energy (fatigue)
- headache
- nausea
- itchy skin
Seek immediate medical attention if you experience:
- swelling of the face, lips, mouth, tongue or throat which may cause difficulty swallowing or breathing
Important Warnings
Before taking Maviret, it’s crucial to discuss your medical history and current medications with your doctor to ensure it’s safe for you.
Who Should Not Take Maviret
Do not take Maviret if you are allergic to glecaprevir, pibrentasvir, or any other ingredients in the medication. Do not take it if you have moderate or severe liver disease. Avoid taking it with certain medications including atazanavir, atorvastatin, simvastatin, dabigatran etexilate, ethinylestradiol-containing products, or rifampicin.
Medical Conditions to Discuss
Tell your doctor if you have liver conditions other than hepatitis C, HIV, hepatitis B, have had a liver or kidney transplant, have diabetes, or any other medical conditions. Also inform them about all medicines you’re taking for any condition.
Pregnancy and Breastfeeding
Make sure your doctor knows if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed. Call your doctor immediately if you become pregnant while taking Maviret.
Children Under 3: Do not give Maviret to children younger than 3 years old.
Drug Interactions
Maviret can interact with many medications, either increasing or decreasing their effectiveness. Some interactions can be dangerous and require avoiding certain medications entirely.
Complete medication review: Tell your doctor about ALL medicines, vitamins, and supplements you take, including those bought without prescription.
- atazanavir (HIV medication)
- atorvastatin (cholesterol medication)
- simvastatin (cholesterol medication)
- dabigatran (blood thinner)
- ethinylestradiol (contraceptive pills, hormone replacement)
- rifampicin (tuberculosis medication)
- darunavir (HIV medication)
- lopinavir (HIV medication)
- ritonavir (HIV medication)
- ciclosporin (immune suppressor)
- carbamazepine (epilepsy medication)
- St. John’s Wort (herbal supplement)
- efavirenz (HIV medication)
- digoxin (heart medication)
- pravastatin (cholesterol medication)
- rosuvastatin (cholesterol medication)
Alcohol & Driving
Maviret is expected to have little to no effect on your ability to drive or operate machinery, but you should be cautious until you know how it affects you personally.
Alcohol
There is no specific information available about the effects of taking Maviret with alcohol. Discuss alcohol consumption with your doctor.
Driving and Operating Machinery
Be careful before you drive or use any machines or tools until you know how Maviret affects you. The medication is expected to have little to no effect on driving ability, but individual responses may vary.
Storage
Store Maviret in a cool, dry place away from moisture, heat, and sunlight. Keep tablets in their original pack until it’s time to take them. Don’t store them in the bathroom, near a sink, in the car, or on window sills. Keep the medication where young children cannot reach it. Don’t use after the expiry date.
Overdose Information
If you take too much Maviret, immediately phone the Poisons Information Centre (13 11 26), contact your doctor, or go to the Emergency Department at your nearest hospital. Do this even if there are no signs of discomfort or poisoning.
Frequently Asked Questions
Your doctor will monitor your progress through regular appointments to check how well the treatment is working. Continue taking Maviret until your doctor tells you to stop.
Yes, you should take Maviret with food. For tablets, take them during a meal or immediately after a meal. For granules, give them just before or after a snack or meal.
If it’s less than 6 hours until your next dose, skip the missed dose. If it’s 6 hours or more until your next dose, take the missed dose and then take your next dose at the usual time. Never take a double dose.
No, do not stop taking Maviret suddenly or change the dose without checking with your doctor first. It’s important to complete your full course of treatment.
There is no specific information available about the effects of taking Maviret with alcohol. You should discuss alcohol consumption with your doctor.
If vomiting occurs within 3 hours of taking your dose, take an additional dose. If vomiting occurs more than 3 hours after taking your dose, no additional dose is needed.
No, do not break, crush, or chew the tablets. Swallow them whole with a full glass of water. For children who cannot swallow tablets, granules are available.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.