Lazcluze (Lazertinib)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Lazcluze Used For?
Lazcluze contains lazertinib and is used in combination with another cancer medicine called amivantamab to treat adults with a specific type of lung cancer.
Primary Uses
Lazcluze is prescribed for adults with non-small cell lung cancer that has spread to other parts of the body and has specific changes in a gene called EGFR (epidermal growth factor receptor). It can be used as the first treatment for this type of lung cancer.
How It Works
Lazcluze works by blocking EGFR, which may help slow or stop lung cancer from growing and may also help reduce the size of tumors.
Combination Treatment: Lazcluze is always used together with amivantamab – make sure to read both medication guides
How to Take Lazcluze
Lazcluze is taken by mouth as a tablet that should be swallowed whole with water.
Dosage Instructions
The recommended dose is 240 mg once daily. Your doctor may reduce your dose to 160 mg or 80 mg daily if needed. Swallow the tablet whole with water – do not crush, split, or chew it. You can take it with or without food. If you vomit after taking Lazcluze, do not take an additional dose – wait until your next scheduled dose.
What If You Miss a Dose?
If you miss your dose, take it as soon as you remember. However, if it’s less than 12 hours until your next dose, skip the missed dose and take your next normal dose at the usual time.
Important: Never take a double dose to make up for a missed dose
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- nail problems
- sores in the mouth
- nerve damage causing tingling, numbness, or pain
- feeling very tired
- constipation or diarrhea
- decreased appetite
- nausea or vomiting
- fever
- muscle spasms
- changes in blood tests
- hand-foot syndrome (redness, swelling, peeling on hands or feet)
- hives
- liver toxicity
Seek immediate medical attention if you experience:
- sudden difficulty breathing, cough, or fever (lung inflammation)
- sharp chest pain, shortness of breath, rapid breathing (blood clots)
- leg pain or swelling of arms or legs (blood clots)
- skin problems including rash, dry skin, itching, pain, redness
- eye problems including redness, pain, vision problems, light sensitivity
Important Warnings
There are several important warnings and precautions to be aware of before taking Lazcluze.
Who Should Not Take Lazcluze
Do not take Lazcluze if you are allergic to lazertinib or any of the other ingredients listed in the medication. Children and adolescents under 18 years should not take this medicine.
Medical Conditions to Discuss
Tell your doctor if you have ever had inflammation of your lungs (interstitial lung disease or pneumonitis), or any other medical conditions. Also inform them about all other medicines you are taking.
Pregnancy and Breastfeeding
Lazcluze is not recommended during pregnancy as it could harm an unborn baby. Both men and women taking Lazcluze and their partners must use reliable contraception during treatment and for 3 weeks after stopping. Do not breastfeed while taking this medicine. Male patients must not donate sperm during treatment and for 3 weeks after completing treatment.
Pregnancy Warning: If you or your partner becomes pregnant while taking Lazcluze, tell your doctor immediately
Drug Interactions
Some medicines may interfere with how Lazcluze works or increase the risk of side effects.
Tell Your Doctor: Always inform your healthcare provider about all medicines, vitamins, and supplements you are taking
- Carbamazepine or phenytoin (anti-epileptic medicines)
- Rifampicin (used to treat tuberculosis)
- St. John’s wort (herbal product for depression)
- Midazolam (sedative)
- Sirolimus or tacrolimus (immune suppressants)
- Rosuvastatin (cholesterol medicine)
- Sulfasalazine (anti-inflammatory)
Alcohol & Driving
Lazcluze does not affect your ability to drive or operate machinery.
Alcohol
No specific alcohol warnings are mentioned in the prescribing information.
Driving and Operating Machinery
Lazcluze does not impair your ability to drive or use machines safely.
Storage
Store Lazcluze below 30°C in a cool, dry place away from moisture, heat, and sunlight. Do not store in the bathroom, near a sink, in the car, or on window sills. Keep out of reach of children. Do not use after the expiry date shown on the packaging.
Overdose Information
If you take more than the normal dose, you may have an increased risk of side effects requiring urgent medical attention. Immediately contact your doctor or call the Poisons Information Centre at 13 11 26, even if you feel fine.
Frequently Asked Questions
Lazcluze works by blocking EGFR to help slow or stop lung cancer growth and may help reduce tumor size, but the timeline for seeing effects varies by individual and should be discussed with your doctor.
Yes, you can take Lazcluze with or without food. Swallow the tablet whole with water.
Take the missed dose as soon as you remember, but if it’s less than 12 hours until your next dose, skip the missed dose. Never take a double dose to make up for a missed one.
Do not stop taking Lazcluze unless your doctor tells you to. This medication is treating your cancer, so stopping without medical supervision could be harmful.
No, you must swallow Lazcluze tablets whole with water. Do not crush, split, or chew the tablets.
Do not take an additional dose if you vomit after taking Lazcluze. Wait until your next scheduled dose time.
Yes, both men and women taking Lazcluze and their partners must use reliable contraception during treatment and for 3 weeks after completing treatment.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.