Jemperli (Dostarlimab)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Jemperli Used For?
Jemperli contains dostarlimab, a specialized protein designed to help your immune system fight cancer. It’s used specifically for treating endometrial cancer in adults.
Primary Uses
Jemperli is used to treat endometrial cancer (cancer of the lining of the womb) in adults when the cancer has spread, cannot be removed by surgery, and has progressed despite previous treatment. It may be given alone or combined with other cancer medicines.
How It Works
Dostarlimab is a monoclonal antibody that recognizes and attaches to specific targets in your body. It works by helping your immune system fight your cancer more effectively.
How to Take Jemperli
Jemperli is given as an intravenous infusion in a hospital or clinic under supervision of a cancer specialist. You cannot take this medication at home.
Dosage Instructions
When given alone: 500 mg every 3 weeks for 4 doses, then 1000 mg every 6 weeks thereafter. When combined with chemotherapy: 500 mg every 3 weeks for 6 doses, then 1000 mg every 6 weeks as single therapy. Each infusion takes about 30 minutes.
What If You Miss a Dose?
If you miss your scheduled appointment, contact your doctor or hospital immediately to reschedule. It’s very important not to miss doses of this medicine.
Important: Never stop this treatment suddenly and don’t miss scheduled doses – contact your healthcare team immediately if you can’t make an appointment
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- decrease in red blood cells (anemia)
- low thyroid hormone levels
- diarrhea
- nausea
- vomiting
- rash
- itchy skin
- fever
- increased liver enzyme levels
- dry skin (when combined with chemotherapy)
Seek immediate medical attention if you experience:
- lung inflammation (shortness of breath, chest pain, new or worse cough)
- digestive tract inflammation (trouble swallowing, heartburn, severe stomach pain, bloody stools)
- liver inflammation (nausea, vomiting, yellowing of skin/eyes, dark urine, easy bruising)
- hormone gland inflammation (rapid heartbeat, weight changes, hair loss, muscle aches, persistent headache)
- kidney inflammation (changes in urine, ankle swelling, blood in urine)
- skin inflammation (severe rash, mouth/genital ulcers)
- heart muscle inflammation (trouble breathing, chest pain, flu-like symptoms)
- brain/nervous system inflammation (neck stiffness, confusion, muscle weakness, vision problems)
- spinal cord inflammation (numbness, weakness, bladder/bowel problems)
- eye inflammation (vision changes)
- infusion reactions (breathing problems, rash, dizziness, fever, blood pressure drop)
- transplant rejection complications
Important Warnings
Jemperli can cause serious side effects, particularly inflammation of various organs. Your doctor will monitor you closely and may need to adjust or stop treatment if serious side effects occur.
Who Should Not Take Jemperli
Do not use Jemperli if you are allergic to dostarlimab or any ingredients in the medication. Always check the ingredient list to ensure you can safely use this medicine.
Medical Conditions to Discuss
Tell your doctor if you have immune system problems, lung or breathing problems, liver or kidney problems, serious rash, or any other medical conditions. Also inform them about all other medicines you’re taking.
Pregnancy and Breastfeeding
You must not receive Jemperli if pregnant unless specifically recommended by your doctor, as it can harm or kill your unborn baby. Women who could become pregnant must use effective contraception during treatment and for at least 4 months after the last dose. Do not breastfeed during treatment and for at least 4 months after your last dose.
Transplant Recipients: This medication can cause serious complications including organ transplant rejection and graft-versus-host disease in bone marrow transplant recipients, which can be life-threatening
Drug Interactions
Some medicines may interfere with how Jemperli works. Your doctor may prescribe corticosteroids to reduce side effects during treatment.
- corticosteroids (may be given to reduce side effects)
Alcohol & Driving
Jemperli is unlikely to directly affect your ability to drive, but side effects may impact your concentration and reaction time.
Alcohol
No specific alcohol restrictions are mentioned, but discuss alcohol consumption with your doctor as it may interact with other medications you’re taking for side effects.
Driving and Operating Machinery
Be careful when driving or using machines until you know how Jemperli affects you. If you experience side effects that affect your ability to concentrate and react, avoid driving or operating machinery.
Storage
Jemperli will be stored and handled by healthcare professionals at the hospital or clinic. The medicine is stored in its original container in a refrigerator at 2°C to 8°C. You don’t need to worry about storage as this is handled by your medical team.
Overdose Information
Since Jemperli is given by healthcare professionals in a controlled hospital setting, overdose is unlikely. Your medical team carefully calculates and monitors your dose. If you experience any concerning symptoms during or after treatment, inform your healthcare team immediately.
Frequently Asked Questions
The timeline for Jemperli to show effects varies by individual and depends on your specific cancer situation. Your doctor will monitor your progress and determine how many treatments you need based on your response.
Tell your doctor about all medicines you’re taking. Some medicines may interfere with Jemperli. Your doctor may prescribe corticosteroids during treatment to help reduce side effects.
Contact your doctor or hospital immediately to reschedule if you miss an appointment. It’s very important not to miss doses of this medicine as it’s given on a specific schedule for maximum effectiveness.
No, you must not receive Jemperli if you’re pregnant unless your doctor specifically recommends it, as it can harm your unborn baby. Use effective contraception during treatment and for at least 4 months after your last dose.
Watch for signs of inflammation including breathing problems, severe stomach pain, yellowing of skin or eyes, persistent headaches, vision changes, or severe rash. Contact your doctor immediately if you experience any of these symptoms.
Jemperli is given as an intravenous infusion (drip into your vein) over about 30 minutes in a hospital or clinic under supervision of a cancer specialist. You cannot take this medication at home.
No, you must not breastfeed during treatment and for at least 4 months after your last dose. It’s unknown if Jemperli passes into breast milk, so this precaution protects your baby.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.