Zejula Tablets (Niraparib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Zejula Tablets Used For?
Zejula tablets contain the active ingredient niraparib, which is used to treat certain types of cancer.
Primary Uses
Zejula is primarily used for treating ovarian, fallopian tube, or peritoneal cancer that has either completely or partially responded to platinum-based chemotherapy.
How It Works
Niraparib is a PARP inhibitor that blocks an enzyme involved in DNA repair, leading to cancer cell death.
Good to know: Zejula is not considered addictive.
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How to Take Zejula Tablets
Follow your doctor's instructions carefully when taking Zejula.
Dosage Instructions
The recommended starting dose is 2 tablets (200 mg) taken once daily. Some patients may start with 3 tablets (300 mg) based on their doctor's assessment.
What If You Miss a Dose?
If you miss a dose, take it at the scheduled time. Do not take an extra dose to make up for a missed one.
Important: Never double the dose if you miss one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Tiredness
- Weakness
- Nausea
- Stomach pain
- Vomiting
- Constipation
- Diarrhoea
- Indigestion
- Decreased appetite
- Inability to sleep
- Headache
- Dizziness
- Runny or stuffy nose
- Shortness of breath
- Cough
- High blood pressure
- Urinary tract infection
- Heart palpitations
- Back pain
- Joint pain
Seek immediate medical attention if you experience:
- Bruising or prolonged bleeding
- Shortness of breath with fatigue or pale skin
- Fever or signs of infection
- Symptoms of low blood cell counts
- Kidney problems
- Allergic reactions including anaphylaxis
Important Warnings
There are several important warnings to consider before taking Zejula.
Who Should Not Take Zejula Tablets
Do not take Zejula if you are allergic to niraparib or any of its ingredients. It is also not suitable for pregnant or breastfeeding women.
Medical Conditions to Discuss
Inform your doctor if you have low blood counts, high blood pressure, myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), or posterior reversible encephalopathy syndrome (PRES).
Pregnancy and Breastfeeding
Zejula can harm an unborn baby and should not be taken during pregnancy or while breastfeeding. Effective contraception is required during treatment and for 6 months after the last dose.
Drug Interactions
Certain medications may interact with Zejula.
- Cyclosporin
- Tacrolimus
- Alfentanil
- Ergotamine
- Pimozide
- Quetiapine
- Clozapine
- Halofantrine
- Theophylline
- Ropinirole
- Irinotecan
- Rosuvastatin
- Simvastatin
- Atorvastatin
- Methotrexate
- Metformin
Alcohol & Driving
Be cautious with alcohol and driving while taking Zejula.
Alcohol
Consult your doctor about alcohol consumption while on Zejula.
Driving and Operating Machinery
Zejula may cause dizziness or weakness. Avoid driving or operating machinery if you experience these symptoms.
Storage
Store Zejula tablets in their original packaging in a cool, dry place below 30°C, out of reach of children.
Overdose Information
If you suspect an overdose, seek immediate medical attention or contact the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The time it takes for Zejula to work can vary by individual, and your doctor will monitor your progress.
You can take Zejula with or without food.
No, Zejula is not considered addictive.
Do not stop taking Zejula without consulting your doctor, as it may worsen your condition.
Consult your doctor regarding alcohol consumption while taking Zejula.
Weight gain is not specifically mentioned as a side effect of Zejula.
Elderly patients should discuss their overall health with their doctor before taking Zejula.
If you miss a dose, take it at the scheduled time, but do not double up on doses.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.