Evoltra (Clofarabine)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Evoltra Used For?
Evoltra is a chemotherapy medication that contains clofarabine, primarily used for treating young patients diagnosed with Acute Lymphoblastic Leukaemia (ALL) when other treatments have not been effective.
Primary Uses
Evoltra is specifically used to treat Acute Lymphoblastic Leukaemia (ALL) in young patients.
How It Works
Evoltra works by interfering with the growth and repair of rapidly multiplying cells, such as cancer cells, leading to their destruction.
Good to know: Evoltra is not considered addictive.
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How to Take Evoltra
Evoltra is administered by a healthcare professional through a slow injection or infusion into a vein.
Dosage Instructions
The dosage of Evoltra is determined by your doctor based on your condition, weight, and response to treatment. It is typically given daily for five days, with the infusion lasting about two hours.
What If You Miss a Dose?
If a dose is missed, contact your healthcare provider for guidance on rescheduling.
Important: Never double the dose if you miss one; always consult your doctor.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- nausea and vomiting
- diarrhea
- headache
- unusual tiredness or weakness
- anxiety or nervousness
- decreased appetite or weight loss
- flushing, itching, and inflamed skin
- skin rashes or flaking
- fever
- infections
- hair loss
Seek immediate medical attention if you experience:
- severe nausea and vomiting
- severe diarrhea
- vomiting blood or stomach pain
- breathing difficulties or cough
- nosebleeds or bleeding gums
- changes in heartbeat
- fluid retention
- high fever
- hearing problems
- dizziness or fainting
- dark urine or blood in urine
- jaundice (yellowing of skin or eyes)
- bruising or changes in skin color
- numbness
- chest pain or joint pain
- allergic reactions
Important Warnings
There are several important considerations before using Evoltra.
Who Should Not Take Evoltra
Do not use Evoltra if you are allergic to clofarabine or any of its ingredients, or if you have severe kidney or liver problems.
Medical Conditions to Discuss
Discuss any history of blood disorders, bone marrow disease, kidney or liver issues, low blood pressure, gout, bowel problems, weakened immunity, or heart disease with your doctor.
Pregnancy and Breastfeeding
Evoltra should not be used during pregnancy unless absolutely necessary. Women of childbearing potential must use effective contraception during treatment and for six months after. Breastfeeding must be discontinued prior to treatment and not resumed for two weeks after.
Drug Interactions
Certain medications may interact with Evoltra, affecting its efficacy.
- other cancer treatments
- some vaccines
- medications affecting the kidneys
- medications affecting the liver
- medications affecting blood pressure or heart function
Alcohol & Driving
Precautions should be taken regarding alcohol consumption and driving while on Evoltra.
Alcohol
Consult your doctor about alcohol consumption while taking Evoltra, as it may increase dizziness.
Driving and Operating Machinery
Be cautious when driving or operating machinery until you know how Evoltra affects you, as it may cause dizziness or light-headedness.
Storage
Evoltra should be stored in a cool, dry place, below 25°C, and will be kept in the pharmacy or ward.
Overdose Information
Overdose is unlikely as Evoltra is administered under medical supervision. If an overdose is suspected, seek immediate medical attention.
Frequently Asked Questions
The effects of Evoltra may take time to manifest as it works to treat cancer cells.
There are no specific instructions regarding food interactions with Evoltra.
Evoltra is not considered addictive.
Consult your doctor before stopping Evoltra, as it may require a gradual discontinuation.
It is advisable to discuss alcohol consumption with your doctor while on Evoltra.
Weight gain is not specifically mentioned as a side effect of Evoltra.
Evoltra is not recommended for use in adults over the age of 65 due to insufficient information.
Contact your healthcare provider for guidance on rescheduling a missed dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.