Coversyl Plus (Perindopril Arginine And Indapamide Hemihydrate)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Coversyl Plus Used For?
Coversyl Plus is a combination medication prescribed specifically for treating high blood pressure (hypertension). It contains two active ingredients that work together to help lower your blood pressure.
Primary Uses
Coversyl Plus is used to treat high blood pressure. High blood pressure occurs when your blood pressure stays higher than needed, even when you are calm and relaxed. If left untreated, it can lead to serious health problems including stroke, heart disease, and kidney failure.
How It Works
Coversyl Plus contains perindopril (an ACE inhibitor) and indapamide (a diuretic or ‘water tablet’). These two ingredients work together to help lower your blood pressure and reduce the strain on your cardiovascular system.
Good to know: There is no evidence that Coversyl Plus is addictive.
How to Take Coversyl Plus
Take Coversyl Plus exactly as prescribed by your doctor. The medication is designed for once-daily dosing to help maintain consistent blood pressure control.
Dosage Instructions
The usual dose is one tablet once daily. Swallow your tablet with water, preferably in the morning. Your doctor will select the appropriate dose when they prescribe Coversyl Plus for you.
What If You Miss a Dose?
If your next usual dose is less than 6 hours away, skip the missed dose and take the next dose at the usual time. If your next dose is more than 6 hours away, take the missed dose as soon as you remember, then take the next dose at the usual time and continue as normal.
Important: Do not try to make up for missed doses by taking more than one dose at a time.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Dry, irritating cough
- Headache, dizziness, pins and needles
- Feeling tired or weak
- Low blood pressure and related effects
- Nausea, vomiting, taste changes, stomach discomfort
- Muscle spasms, tenderness, or weakness
- Skin rash, itching
- Decreased appetite
Seek immediate medical attention if you experience:
- Severe dizziness or fainting from low blood pressure
- Difficulty breathing, wheezing, chest tightness
- Angioedema (swelling of face, lips, mouth, tongue, throat)
- Purple spots with blisters (Stevens-Johnson Syndrome)
- Painful red areas with large blisters and peeling skin (Toxic Epidermal Necrolysis)
- Signs of stroke (weakness, speech problems)
- Heart problems (irregular heartbeat, chest pain)
- Liver disease symptoms (yellowing of skin or eyes)
- Severe muscle pain with fever
- Vision problems or eye pain
Important Warnings
There are important safety considerations and medical conditions that may prevent you from taking Coversyl Plus safely. Always inform your doctor about your complete medical history.
Who Should Not Take Coversyl Plus
Do not take Coversyl Plus if you are allergic to perindopril, indapamide, sulfonamide antibiotics, thiazide diuretics, or other ACE inhibitors. Also avoid if you are pregnant, breastfeeding, have kidney problems with reduced blood supply, severe liver disease, low blood potassium, or have experienced serious swelling reactions (angioedema) in the past. Do not take with aliskiren if you have diabetes or kidney problems, or with sacubitril/valsartan.
Medical Conditions to Discuss
Tell your doctor if you have kidney disease, liver disease, diabetes, gout, heart disease, high or low potassium/sodium levels, hyperparathyroidism, systemic lupus erythematosus, scleroderma, or if you are of African origin (higher risk of angioedema and reduced effectiveness). Also inform them about recent diarrhea/vomiting, salt-restricted diets, or upcoming medical procedures.
Pregnancy and Breastfeeding
Do not take Coversyl Plus if you are pregnant, trying to become pregnant, or breastfeeding. Tell your doctor immediately if you become pregnant while taking this medication, as it may cause serious harm to your unborn baby.
Elderly Patients: Elderly people can generally use Coversyl Plus safely, but some older people have reduced kidney function and may require additional care and monitoring.
Drug Interactions
Coversyl Plus can interact with many other medications, potentially changing how well it works or increasing the risk of side effects. Always tell your doctor about all medications you are taking.
- Steroid medicines
- Other diuretics (amiloride, spironolactone, triamterene)
- Heart rhythm medications (quinidine, amiodarone, sotalol)
- Other blood pressure medications (ACE inhibitors, ARBs, aliskiren)
- Antibiotics (trimethoprim, moxifloxacin, ciprofloxacin)
- Anti-inflammatory drugs (high-dose aspirin, ibuprofen)
- Mental health medications (lithium, antidepressants, antipsychotics)
- Diabetes medications (metformin, insulin, gliptins)
- Potassium supplements and salt substitutes
- Cancer medications (vandetanib, oxaliplatin)
- Immunosuppressants (ciclosporin, tacrolimus)
- Gold salts
- Digoxin and cardiac glycosides
- Calcium supplements
- Stimulant laxatives
Alcohol & Driving
Coversyl Plus can affect your ability to drive and operate machinery, and you should take precautions to stay safe while your body adjusts to the medication.
Alcohol
Information about alcohol interactions was not specifically provided in the source material. Consult your doctor about alcohol consumption while taking Coversyl Plus.
Driving and Operating Machinery
Be careful when driving or operating machinery until you know how Coversyl Plus affects you. You may feel light-headed or dizzy when you begin taking this medication because your blood pressure is falling. If you experience these symptoms when standing up or getting out of bed, try getting up more slowly to allow your body to adjust.
Temperature Regulation
Make sure you drink enough water during exercise and hot weather, especially if you sweat a lot. This will help you avoid dizziness or light-headedness caused by a sudden drop in blood pressure.
Storage
Store Coversyl Plus tablets in a safe place where children cannot reach them – a locked cupboard at least one-and-a-half metres above ground is ideal. Keep tablets in their original pack until it’s time to take them, as they won’t keep as well outside their container. Store in a cool, dry place where the temperature stays below 30°C. Avoid storing in bathrooms, near sinks, in cars, or on windowsills, as heat and dampness can destroy the medicine.
Overdose Information
Taking too much Coversyl Plus can cause dangerously low blood pressure, making you feel dizzy. If this happens, lie down with your legs elevated. Other possible effects include nausea, vomiting, cramps, sleepiness, confusion, and changes in urine production. If you suspect an overdose, act immediately: call your doctor, the Poisons Information Centre (13 11 26 in Australia; 03 474 7000 in New Zealand), or go to the nearest hospital emergency department, even if there are no obvious symptoms.
Frequently Asked Questions
The source material doesn’t specify exactly how long Coversyl Plus takes to work. Your doctor will monitor your blood pressure to determine how well the medication is working for you.
The medication should be swallowed with water, preferably in the morning. The source doesn’t specify whether it should be taken with or without food – consult your doctor or pharmacist for specific guidance.
No, there is no evidence that Coversyl Plus is addictive.
Do not stop taking Coversyl Plus or change the dose without checking with your doctor. Coversyl Plus helps control your blood pressure but cannot cure the condition, so treatment is usually lifelong.
Yes, elderly people can generally use Coversyl Plus safely. However, some older people have reduced kidney function, in which case additional care and monitoring may be required.
If your next dose is less than 6 hours away, skip the missed dose. If it’s more than 6 hours away, take the missed dose as soon as you remember, then continue with your regular schedule. Never take two doses at once to make up for a missed dose.
The source material doesn’t provide specific information about alcohol interactions. You should consult your doctor about alcohol consumption while taking Coversyl Plus.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.