Evenity (Romosozumab)

Complete patient guide for uses, dosage, side effects, and safety information

Prescription Required

Quick Facts

Generic Name

romosozumab

Drug Class

sclerostin inhibitor

Used For

osteoporosis in postmenopausal women and men

How Taken

subcutaneous injection (2 injections monthly for 12 months)

What Is Evenity Used For?

Evenity is a prescription medication that helps build stronger bones by working in two ways – it builds new bone while preventing the breakdown of existing bone.

Primary Uses

Evenity is used to treat osteoporosis in women after menopause and osteoporosis in men. Osteoporosis is a condition where bones become thin and fragile, making them more likely to break, especially in the spine, hips, and wrists.

How It Works

Evenity works by blocking a protein called sclerostin. By preventing sclerostin’s activity, Evenity both builds new bone and decreases the breakdown of existing bone, which strengthens bones, improves bone mass and structure, and lowers the chance of breaking bones.

Good to know: After completing your 12-month course of Evenity, you’ll need to continue with another osteoporosis treatment to maintain bone strength.

How to Take Evenity

Evenity is given as an injection under the skin (subcutaneous injection) by a healthcare professional or trained caregiver.

Dosage Instructions

The usual dose is 210 mg given as two separate 105 mg injections, one after the other, on the same day. You’ll receive this dose once every month for 12 months. Your doctor may train you or your caregiver to give the injections at home.

What If You Miss a Dose?

If you miss your monthly dose, take it as soon as possible. Then schedule your next dose one month from the date of your last injection. Continue with your regular monthly schedule from there.

Important: Never take a double dose to make up for a missed injection. Only use Evenity if you’ve received proper training on how to inject it.

Available Tablet Strengths

105 mg/1.17 mL

105 mg/1.17 mL Tablet Clear to opalescent, Prefilled syringe • colourless to light yellow liquid

Side Effects

Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.

Common Side Effects

These side effects occur relatively frequently and usually don’t require emergency care:

Injection site reactions (redness, bruising, or pain)
Cold-like symptoms (runny nose, sore throat, cough)
Headache
Joint pain
Neck pain
Swelling of hands, ankles, or feet

Seek immediate medical attention if you experience:

Serious allergic reactions (rash, itching, hives, swelling of face/lips/mouth/tongue/throat)
Heart attack symptoms (chest pain or pressure, shortness of breath, light-headedness)
Stroke symptoms (headache, numbness or weakness in face/arm/legs, difficulty talking, vision changes, loss of balance)
Low calcium symptoms (muscle spasms, twitches, cramps, numbness or tingling in fingers/toes/around mouth)
Jaw bone problems (loose teeth, mouth or jaw pain/swelling, non-healing mouth sores)

Important Warnings

Evenity has several important warnings and is not suitable for everyone. Make sure to discuss your medical history with your doctor.

Who Should Not Take Evenity

Do not use Evenity if you have a history of heart attack or stroke, have low calcium levels in your blood (hypocalcemia), are allergic to romosozumab or any ingredients, or are a child or adolescent.

Medical Conditions to Discuss

Tell your doctor if you’re taking other osteoporosis medicines (like denosumab or bisphosphonates), have previously had low calcium or vitamin D levels, have problems with your mouth, jaw bone or teeth, have increased cardiovascular risk factors (heart disease, high blood pressure, high cholesterol, diabetes, smoking, kidney problems), or have allergies to other medicines.

Pregnancy and Breastfeeding

Evenity has not been tested in pregnant women and is not intended for use during pregnancy. It’s unknown if Evenity passes into breast milk. Tell your doctor if you’re pregnant, planning to become pregnant, or breastfeeding.

Cardiovascular Risk: An increase in serious cardiovascular events (heart attack and stroke) has been reported in patients treated with Evenity.

Drug Interactions

Tell your doctor about all medicines, vitamins, and supplements you’re taking, including those bought without a prescription.

Other osteoporosis medicines (denosumab/Prolia)
Bisphosphonates
Calcium supplements
Vitamin D supplements

Alcohol & Driving

Be cautious when driving or operating machinery until you know how Evenity affects you.

Alcohol

There is no specific information available about the effects of using Evenity with alcohol.

Driving and Operating Machinery

Evenity has no known effects on your ability to drive or use machines, but as a general precaution, avoid driving soon after you have an injection.

Storage

Store Evenity in the refrigerator between 2°C and 8°C. Do not freeze or shake. Keep in the original carton to protect from light. You may remove it from the refrigerator to reach room temperature (up to 25°C) before injection for comfort, but it must be used within 30 days or discarded. Keep away from children.

Overdose Information

If you think you’ve used too much Evenity, seek urgent medical attention immediately. Call the Poisons Information Centre (13 11 26), contact your doctor, or go to the nearest hospital Emergency Department, even if you feel fine.

Frequently Asked Questions

Evenity treatment lasts for 12 months, with one dose (2 injections) given every month. After completing the 12-month course, you’ll need to switch to another osteoporosis treatment to maintain bone strength.

Yes, your doctor may decide that you or your caregiver can inject Evenity at home, but only after receiving proper training from a healthcare professional. Do not attempt to use Evenity without proper training.

Contact your doctor immediately if you experience loose teeth, mouth or jaw pain or swelling, or non-healing mouth sores. Practice good dental hygiene and have routine dental check-ups during treatment.

Take calcium and vitamin D supplements if your doctor has told you to. Your doctor may check your blood calcium levels before starting Evenity, as low calcium levels are a contraindication for this medication.

If you miss your dose, take it as soon as possible. Then schedule your next injection one month from the date of your last injection. Do not take a double dose to make up for the missed injection.

Yes, an increase in serious cardiovascular events (heart attack and stroke) has been reported with Evenity. Do not use Evenity if you have a history of heart attack or stroke. Contact your doctor immediately if you experience chest pain, shortness of breath, or stroke symptoms.

Evenity should be stored in the refrigerator (2°C to 8°C). You can remove it from the refrigerator to reach room temperature before injection for comfort, but once removed, it must be used within 30 days or discarded.

Important Disclaimer

This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.

If you think you may have a medical emergency, call your doctor or emergency services immediately.