If you’ve ever struggled with severe acne, you’ve probably heard of Accutane. This powerful prescription medication is known for its ability to clear up even the most stubborn acne cases. But with great results come great concerns—one of the most common questions people ask is: Does Accutane cause weight gain?
What is Accutane?
Accutane, also known as isotretinoin, is a retinoid derived from vitamin A. It works by reducing the amount of oil (sebum) produced by your skin’s sebaceous glands. Less oil means fewer clogged pores, which helps clear up acne. However, because Accutane is a strong medication, it comes with a list of potential side effects—including dry skin, chapped lips, joint pain, and sometimes mood changes. But does Accutane cause weight gain? That’s a question we need to explore in depth.
Does Accutane Cause Weight Gain? What Research Says
There is no direct evidence that Accutane causes weight gain. In fact, scientific studies and clinical trials do not list weight gain as a common or direct side effect. The U.S. Food and Drug Administration (FDA) and dermatologists worldwide have not identified weight gain as a frequent issue associated with isotretinoin use.
However, that doesn’t mean some people don’t experience weight fluctuations while taking the medication. So, why do some people believe Accutane causes weight gain?

Possible Reasons People Might Gain Weight on Accutane
While there’s no direct link between Accutane and weight gain, certain indirect factors could contribute to changes in weight:
Changes in Appetite
Some users report an increased or decreased appetite while taking Accutane. While this isn’t common, a shift in eating habits could potentially lead to weight gain or loss.
Mood Changes and Emotional Eating
Accutane has been associated with mood changes, including depression and anxiety. For some individuals, emotional eating can lead to weight gain, making it seem like Accutane is the cause.
Reduced Physical Activity
Joint and muscle pain are potential side effects of Accutane. If you experience discomfort, you may reduce your exercise routine, leading to weight gain over time.
Water Retention and Temporary Bloating
Some users report feeling bloated or swollen while on Accutane. This could be due to mild inflammation or water retention, but it’s usually temporary and not actual weight gain.
Hormonal Changes
Accutane affects the sebaceous glands and can also have an impact on hormone levels. While the connection isn’t clear, some people may experience minor fluctuations in body weight due to hormonal changes.
Accutane and Weight Loss – The Other Side of the Story
Interestingly, while some people wonder, “Does Accutane cause weight gain?”, others actually report weight loss. This can be due to:
- A decrease in appetite (some users say they eat less on Accutane)
- Gastrointestinal side effects like nausea
- Increased metabolism in certain individuals
Since every person’s body reacts differently, Accutane may have varying effects on weight, but no consistent pattern has been established.
What Do Dermatologists Say?
Dermatologists widely agree that Accutane does not directly cause weight gain. In medical studies and patient reports, weight gain is not listed as a major concern. If you notice significant weight changes while taking Accutane, it may be worth discussing with your doctor to see if other factors—such as diet, lifestyle, or another medication—are playing a role.
Tips to Maintain a Healthy Weight While on Accutane
If you’re concerned about does Accutane cause weight gain, here are some practical ways to maintain a balanced weight while on the medication:
- Stick to a Nutrient-Rich Diet – Focus on whole foods, lean proteins, healthy fats, and plenty of fruits and vegetables.
- Stay Hydrated – Accutane can cause dryness, so drinking enough water is essential for both your skin and overall health.
- Monitor Your Eating Habits – If you notice changes in your appetite, try to maintain regular, balanced meals to avoid unintentional weight gain.
- Stay Active – If Accutane makes exercise uncomfortable, try low-impact activities like swimming, yoga, or walking.
- Track Your Progress – If you’re worried about weight fluctuations, keeping a journal can help you identify any patterns.

Does Accutane Cause Weight Gain?
To sum it up, there is no scientific proof that Accutane directly causes weight gain. While some users experience changes in appetite, emotional eating, or reduced activity due to joint pain, these are indirect factors rather than a direct side effect of the drug. If you are taking Accutane and notice weight gain, consider evaluating your diet, exercise routine, and emotional health.
If you have concerns, always speak with your dermatologist or healthcare provider. Accutane is a powerful medication that can deliver life-changing results for acne sufferers, and understanding how it affects your body is key to a successful treatment journey.
Have you taken Accutane? Did you notice any weight changes? Let us know in the comments below!