Augtyro (Repotrectinib)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Augtyro Used For?
Augtyro is a targeted cancer treatment specifically designed for adults with a particular type of lung cancer.
Primary Uses
Augtyro is used to treat adults with non-small cell lung cancer (NSCLC) that is caused by a change in the ROS1 gene. Your doctor will have done a test to confirm that your cancer cells have this specific ROS1 gene change, and your cancer must be advanced (meaning it has spread to other parts of your body).
How It Works
The ROS1 gene normally provides instructions for making ROS1 proteins. When this gene is changed, it creates abnormal proteins that cause cancer cells to grow uncontrollably. Augtyro works by blocking these abnormal ROS1 proteins, which may slow or stop cancer cell growth and help shrink your cancer.
How to Take Augtyro
Your doctor will determine the right dose for you and provide specific instructions on how to take this medication properly.
Dosage Instructions
The recommended starting dose is 160 mg once a day for the first 14 days, followed by 160 mg twice a day. Take Augtyro by mouth with or without food. Swallow each capsule whole – do not open, crush, chew, or dissolve the capsules. Your doctor may adjust your dose or pause treatment based on how you respond. For lower doses, you may need to take multiple capsules since they only come in 40mg or 160mg strengths.
What If You Miss a Dose?
If you miss a dose or vomit after taking a dose, take the next dose as prescribed at your regular time. Do not take a double dose to make up for a missed dose.
Important: Never double your dose if you miss one – just continue with your regular schedule
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Taste changes
- Numbness and tingling sensations
- Constipation
- Feeling tired
- Changes in thinking patterns
- Nausea
- Muscle weakness
- Headache
- Sleep problems
- Weight gain
- Joint pain
- Vomiting
- Vision problems
- Diarrhea
- Muscle pain
- Arm and leg pain
- Falls
- Bone fractures
Seek immediate medical attention if you experience:
- Central nervous system effects (dizziness, mood changes, hallucinations, confusion, coordination problems)
- Lung problems (new or worsening cough, shortness of breath, fever)
- Liver problems (yellowing of skin or eyes, dark urine, light stools, stomach pain)
- Muscle problems (unexplained muscle pain, tenderness, weakness)
- Increased uric acid (joint swelling, decreased urination, blood in urine)
- Bone fractures and abnormalities
Important Warnings
There are several important safety considerations you should know before starting Augtyro treatment.
Who Should Not Take Augtyro
Do not take Augtyro if you are allergic to repotrectinib or any other ingredients in the medication. Do not take this medication if you are pregnant or planning to become pregnant.
Medical Conditions to Discuss
Tell your doctor if you have recently experienced dizziness, memory loss, confusion, hallucinations, mental status changes, loss of muscle coordination, or unsteady walking. Also inform your doctor if you have ever had any lung problems, as you should watch for new or worsening symptoms like shortness of breath, cough, or fever.
Pregnancy and Breastfeeding
Augtyro can harm an unborn baby. If you can become pregnant, use highly effective non-hormonal contraception during treatment and for at least 2 months after stopping. If your partner can become pregnant, use effective contraception during treatment and for at least 4 months after stopping. Hormonal birth control methods may not work with Augtyro. Do not breastfeed while taking this medication as it’s unknown if it passes into breast milk.
Drug Interactions
Several medications and substances can affect how Augtyro works in your body, so it’s important to tell your doctor about everything you’re taking.
Grapefruit interaction: Do not drink grapefruit juice or eat grapefruit during treatment as it may increase the medicine in your blood to harmful levels
- HIV/AIDS medications (ritonavir, saquinavir)
- Antifungal medications (ketoconazole, itraconazole, voriconazole, posaconazole)
- Anti-seizure medications (carbamazepine, phenytoin)
- Tuberculosis medications (rifampin)
- St. John’s Wort (herbal antidepressant)
- Cancer medications (apalutamide)
- Immunosuppressive medications (sirolimus, tacrolimus, cyclosporin)
- Pain medications (alfentanil)
- Antidepressants (bupropion)
Alcohol & Driving
Augtyro can affect your ability to safely drive or operate machinery, so it’s important to be aware of how this medication affects you.
Alcohol
The source material does not provide specific information about alcohol interactions with Augtyro. Discuss alcohol use with your doctor.
Driving and Operating Machinery
Augtyro may cause dizziness, impaired balance or coordination, fainting, fatigue, mental status changes, confusion, hallucinations, or blurred vision. If you experience any of these symptoms, do not drive, use a bicycle, or operate heavy machinery until your symptoms resolve. Talk to your doctor about whether it’s safe for you to drive or use machines.
Storage
Store Augtyro in a cool, dry place away from moisture, heat, and sunlight. Do not store it in the bathroom, near a sink, in the car, or on window sills. Keep this medication out of sight and reach of children. Do not use after the expiry date on the package.
Overdose Information
If you think you have taken too much Augtyro, seek urgent medical attention immediately. Contact the Poisons Information Centre (13 11 26), your doctor, or go to the nearest hospital emergency department right away. Take the medicine pack and this leaflet with you, even if you don’t feel unwell.
Frequently Asked Questions
The source material does not specify how long Augtyro takes to work. Your doctor will monitor your progress through regular appointments to check how well the treatment is working for you.
Yes, you can take Augtyro with or without food. Swallow the capsules whole – do not open, crush, chew, or dissolve them.
If you miss a dose or vomit after taking a dose, take the next dose as prescribed at your regular time. Do not take a double dose to make up for a missed dose.
No, do not drink grapefruit juice or eat grapefruit during your treatment with Augtyro. It may increase the amount of medicine in your blood to a harmful level.
Do not stop taking Augtyro unless your doctor tells you to. It’s important to take Augtyro every day for as long as your doctor prescribes it. If you want to stop, talk to your doctor first.
Yes, weight gain is listed as a very common side effect of Augtyro. Speak to your doctor if this side effect worries you.
Remind any doctor (including surgeons), dentist, or pharmacist you visit that you are taking Augtyro, as it may interact with other medications or affect medical procedures.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.