Rapamune Tablets (Sirolimus)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Rapamune Tablets Used For?
Rapamune contains sirolimus, an immunosuppressant that helps control the immune system after an organ transplant, specifically to prevent the rejection of a transplanted kidney.
Primary Uses
Used primarily for preventing kidney transplant rejection.
How It Works
Sirolimus works by suppressing the immune response, reducing the likelihood of organ rejection.
Good to know: Rapamune is not habit-forming.
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How to Take Rapamune Tablets
Take Rapamune exactly as prescribed by your doctor. It is important to follow the dosage instructions carefully.
Dosage Instructions
The typical starting dose is 6 mg after transplantation, followed by 2 mg once daily. Your doctor will adjust your dose as necessary.
What If You Miss a Dose?
If you miss a dose and it's within 4 hours of your next scheduled dose, skip the missed dose. Otherwise, take it as soon as you remember, but do not double the dose.
Important: Never double dose to make up for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- burning sensation during urination
- increased thirst and hunger
- fluid retention
- abnormal wound healing
- fast heartbeat
- pain
- diarrhea
- mouth ulcers
- cold sores
- nosebleeds
- pneumonia
- acne
- rash
- fever
- headache
- constipation
- nausea
- changes in menstrual bleeding patterns
Seek immediate medical attention if you experience:
- allergic reactions such as rash, itching, or hives
- swelling of the face, lips, or tongue
- shortness of breath or wheezing
- excessive fluid on the lungs
- persistent flu-like symptoms
- new or changing lumps, spots, or moles
- signs of blood disorders
- symptoms of blood clots
- headaches, confusion, seizures, or visual disturbances
Important Warnings
There are several important warnings to consider before taking Rapamune.
Who Should Not Take Rapamune Tablets
Do not take Rapamune if you have had an allergic reaction to sirolimus or any of its ingredients.
Medical Conditions to Discuss
Inform your doctor if you have liver problems, high fat levels in the blood, or a condition called rhabdomyolysis.
Pregnancy and Breastfeeding
Rapamune is not recommended during pregnancy or breastfeeding. Effective contraception is advised during treatment and for 12 weeks after stopping.
Drug Interactions
Certain medications can interact with Rapamune, affecting its effectiveness.
Grapefruit interaction: Avoid grapefruit juice while taking Rapamune.
- ciclosporin
- rifampicin
- clarithromycin
- erythromycin
- rifabutin
- ketoconazole
- clotrimazole
- fluconazole
- voriconazole
- itraconazole
- diltiazem
- verapamil
- carbamazepine
- phenobarbitone
- phenytoin
- cimetidine
- cisapride
- metoclopramide
- danazol
- bromocriptine
- letermovir
- ritonavir
- boceprevir
- telaprevir
- indinavir
- perindopril
- ramipril
- cannabidiol
- St. John's Wort
Alcohol & Driving
Be cautious when drinking alcohol or driving while taking Rapamune.
Alcohol
Consult your doctor about alcohol consumption while on Rapamune.
Driving and Operating Machinery
Be careful when driving or using machinery until you know how Rapamune affects you.
Storage
Store Rapamune tablets in their blister pack in a cool, dry place below 25°C. Keep them away from moisture and out of reach of children.
Overdose Information
If you suspect an overdose, seek immediate medical help. Contact the Poisons Information Centre at 13 11 26 or go to the nearest hospital.
Frequently Asked Questions
Rapamune starts to work after you begin taking it, but the full effect may take time as your doctor adjusts your dosage.
You can take Rapamune with or without food, but avoid grapefruit juice.
No, Rapamune is not considered addictive.
Do not stop taking Rapamune without consulting your doctor, as it may lead to organ rejection.
Consult your doctor regarding alcohol consumption while on Rapamune.
Weight gain is not specifically mentioned as a side effect, but monitor your health and discuss any concerns with your doctor.
Elderly patients should discuss their health conditions with their doctor before taking Rapamune.
If you miss a dose, skip it if it's close to your next dose. Otherwise, take it as soon as you remember, but do not double the dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.