Perjeta (Pertuzumab)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Perjeta Used For?
Perjeta is a medication that contains the active ingredient pertuzumab, which is used to treat certain stages of breast cancer.
Primary Uses
Perjeta is used for metastatic (spreading) breast cancer and early breast cancer, either before or after surgery. It is prescribed only for patients whose tumors test positive for HER2.
How It Works
Perjeta works by recognizing and binding to the HER2 protein found in large amounts on some cancer cells, potentially killing them or slowing their growth.
Good to know: Perjeta is not addictive.
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How to Take Perjeta
Perjeta is administered by a healthcare professional through an IV infusion in a hospital or clinic.
Dosage Instructions
The first infusion is 840 mg given over 60 minutes. Subsequent infusions are 420 mg given over 30-60 minutes, every three weeks.
What If You Miss a Dose?
If you miss an appointment for your infusion, reschedule as soon as possible. If it has been 6 weeks or more since your last dose, the initial high dose will be given again.
Important: Never double the dose if you miss an appointment.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Fatigue
- Nausea
- Diarrhea
- Rash
- Hair loss
- Shortness of breath
Seek immediate medical attention if you experience:
- Severe allergic reactions (difficulty breathing, swelling)
- Heart problems (irregular heartbeat, severe chest pain)
- Severe diarrhea
- Fever or chills
Important Warnings
There are several important considerations before using Perjeta.
Who Should Not Take Perjeta
Do not use Perjeta if you are allergic to pertuzumab or any of its ingredients, if you are pregnant, or if the packaging is damaged or expired.
Medical Conditions to Discuss
Inform your doctor if you have a history of heart problems, have been treated with anthracyclines, or have digestive tract inflammation.
Pregnancy and Breastfeeding
Perjeta should not be taken during pregnancy as it may harm the unborn baby. Effective contraception is advised during treatment and for 7 months after. Breastfeeding is not recommended without consulting a doctor.
Elderly Patients With Dementia: Special caution is advised for elderly patients, particularly those with dementia.
Drug Interactions
Certain medications may interact with Perjeta.
Grapefruit interaction: Consult your doctor about potential interactions with grapefruit.
- Chemotherapy medicines known as anthracyclines (e.g., doxorubicin)
- Other medications that may affect heart function
Alcohol & Driving
Be cautious with alcohol consumption and driving while on Perjeta.
Alcohol
Discuss alcohol use with your doctor.
Driving and Operating Machinery
It is unknown if Perjeta affects your ability to drive or operate machinery; exercise caution.
Storage
Store Perjeta in a refrigerator at 2°C to 8°C and do not use it after the expiration date.
Overdose Information
Overdose is unlikely as Perjeta is administered under medical supervision. If you experience side effects, contact your doctor immediately.
Frequently Asked Questions
The time it takes for Perjeta to show effects can vary depending on individual response to treatment.
There are no specific instructions regarding food interactions; consult your doctor for personalized advice.
No, Perjeta is not considered addictive.
Do not stop taking Perjeta without consulting your doctor, as this may affect your treatment outcomes.
Discuss alcohol consumption with your healthcare provider to understand any potential risks.
Weight gain is not specifically mentioned as a side effect of Perjeta; however, consult your doctor for any concerns.
Elderly patients should use Perjeta with caution, especially those with dementia.
If you miss a dose, reschedule your appointment as soon as possible; do not wait for the next scheduled infusion.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.