Noxafil concentrated injection (Posaconazole)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Noxafil concentrated injection Used For?
Noxafil concentrated injection contains posaconazole, an antifungal medication used to treat and prevent serious fungal infections.
Primary Uses
It is used to treat invasive aspergillosis, fusariosis, zygomycosis, chromoblastomycosis, mycetoma, and coccidioidomycosis. It is also used to prevent fungal infections in high-risk patients.
How It Works
Posaconazole works by inhibiting the growth of fungi that cause infections.
Good to know: Noxafil is not considered addictive.
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How to Take Noxafil concentrated injection
Noxafil is typically given as a diluted slow infusion into a vein.
Dosage Instructions
The usual starting dose is 300 mg twice on the first day, followed by 300 mg once daily thereafter.
What If You Miss a Dose?
It is unlikely to miss a dose as it is administered under medical supervision. If you think a dose has been missed, inform your doctor or pharmacist.
Important: Never double the dose if you miss one.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Abnormal skin sensations
- Loss of appetite
- Stomach pain
- Dry mouth
- Dizziness
- Headache
Seek immediate medical attention if you experience:
- Swelling of the face, lips, mouth, throat, or neck
- Nausea or vomiting
- Diarrhoea
- Yellowing of the skin or eyes
- Unusually dark urine or pale faeces
- Unusual tiredness or weakness
Important Warnings
There are specific warnings regarding who should not use Noxafil.
Who Should Not Take Noxafil concentrated injection
Do not use if allergic to posaconazole or any of its ingredients.
Medical Conditions to Discuss
Discuss any history of kidney, liver, or heart problems, and any issues with potassium, magnesium, or calcium levels.
Pregnancy and Breastfeeding
Noxafil should not be used during pregnancy or breastfeeding unless directed by a doctor. Women of childbearing potential should use effective contraception during treatment and for two weeks after.
Drug Interactions
Some medications can interact with Noxafil, affecting its effectiveness or increasing side effects.
- terfenadine
- astemizole
- cisapride
- pimozide
- quinidine
- ergotamine
- dihydroergotamine
- halofantrine
- simvastatin
- lovastatin
- atorvastatin
- rivaroxaban
- apixaban
- rifabutin
- phenytoin
- efavirenz
- fosamprenavir
- cimetidine
- ranitidine
- omeprazole
- vincristine
- vinblastine
- cyclosporine
- tacrolimus
- sirolimus
- midazolam
- digoxin
- sulfonylureas
- protease inhibitors
Alcohol & Driving
Use caution when driving or operating machinery while taking Noxafil, as it may cause dizziness or blurred vision.
Alcohol
Consult your doctor regarding alcohol consumption while on Noxafil.
Driving and Operating Machinery
Be careful when driving or using tools until you know how Noxafil affects you.
Storage
Store Noxafil concentrated injection in a refrigerator at 2°C – 8°C. Once prepared, use it immediately or store it for up to 24 hours at the same temperature.
Overdose Information
In case of overdose, seek immediate medical attention. Contact the Poisons Information Centre at 13 11 26 or go to the nearest hospital.
Frequently Asked Questions
The time it takes for Noxafil to work can vary based on the type of infection being treated.
Consult your doctor or pharmacist regarding food interactions with Noxafil.
Noxafil is not considered addictive.
Consult your doctor before stopping Noxafil to discuss any potential risks.
It's best to consult your doctor regarding alcohol consumption while on Noxafil.
Weight gain is not commonly associated with Noxafil, but consult your doctor if you have concerns.
Elderly patients should discuss their health conditions with their doctor before starting Noxafil.
Inform your doctor or pharmacist if you think a dose has been missed.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.