Kadcyla (Trastuzumab Emtansine)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Kadcyla Used For?
Kadcyla is a medication that contains trastuzumab emtansine, used primarily for treating HER2-positive breast cancer.
Primary Uses
Kadcyla is used to treat early breast cancer after surgery and advanced or metastatic HER2-positive breast cancer.
How It Works
Kadcyla combines trastuzumab, a monoclonal antibody that targets the HER2 protein on cancer cells, with emtansine, an anti-cancer agent, to deliver treatment directly to the cancer cells.
Good to know: Kadcyla is not addictive.
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How to Take Kadcyla
Kadcyla is administered by a healthcare professional through an IV infusion.
Dosage Instructions
Kadcyla is given once every three weeks. The first infusion lasts 90 minutes, but if tolerated well, subsequent infusions may be shortened to 30 minutes.
What If You Miss a Dose?
If you miss an appointment for your Kadcyla infusion, schedule a new appointment as soon as possible; do not wait for the next planned appointment.
Important: Never double dose if you miss an appointment.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Fatigue
- Nausea
- Vomiting
- Diarrhea
- Bruising or bleeding easily
- Insomnia
- Weakness
Seek immediate medical attention if you experience:
- Severe allergic reactions (swelling of face, lips, tongue, or throat)
- Difficulty breathing
- Irregular heartbeat
- Severe skin reactions (rash, hives)
- Chest pain
- Jaundice (yellowing of skin and eyes)
- Dark urine
Important Warnings
There are several important warnings associated with Kadcyla.
Who Should Not Take Kadcyla
Do not use Kadcyla if you have a known allergy to trastuzumab emtansine or any of its ingredients.
Medical Conditions to Discuss
Discuss any history of heart problems, lung issues, liver problems, or bleeding disorders with your doctor.
Pregnancy and Breastfeeding
Kadcyla may harm an unborn baby; effective contraception is advised during treatment and for at least 7 months after. It is recommended to avoid breastfeeding during treatment and for 7 months after.
Drug Interactions
Certain medications may interact with Kadcyla.
- Oral antifungal medications (e.g., ketoconazole, itraconazole)
- Some antibiotics (e.g., clarithromycin)
- Medications for hepatitis
- Antidepressants
Alcohol & Driving
Be cautious about alcohol consumption and operating machinery while on Kadcyla.
Alcohol
Discuss alcohol use with your doctor.
Driving and Operating Machinery
Be careful when driving or using machines until you know how Kadcyla affects you.
Storage
Store Kadcyla in a refrigerator at 2°C to 8°C. Do not freeze.
Overdose Information
Overdose is unlikely as Kadcyla is administered under medical supervision. If you experience severe side effects, inform your doctor or nurse immediately.
Frequently Asked Questions
The effects of Kadcyla can vary by individual; your doctor will monitor your progress.
There are no specific dietary restrictions mentioned for Kadcyla.
No, Kadcyla is not considered addictive.
Do not stop taking Kadcyla without consulting your doctor first.
Discuss your alcohol consumption with your doctor.
Weight gain may occur; monitor any significant changes and inform your doctor.
Elderly patients should discuss their overall health and any specific concerns with their doctor before starting Kadcyla.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.