Alprolix (Eftrenonacog Alfa (Recombinant Coagulation Factor Ix Fusion Protein))
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Alprolix Used For?
Alprolix is a specialized medication designed to help people with haemophilia B, a condition where the body doesn't have enough factor IX to control bleeding properly.
Primary Uses
Alprolix is used to control and prevent bleeding episodes, routinely prevent and reduce the frequency of bleeding episodes, and reduce bleeding before, during, and after surgery in people with haemophilia B.
How It Works
People with haemophilia B lack sufficient factor IX to control bleeding. Alprolix works by replacing factor IX to enable blood to clot properly.
Good to know: This medicine helps to control your condition but does not cure it.
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How to Take Alprolix
Alprolix is given by slow injection directly into your veins. Your doctor will determine the exact amount you need based on your individual requirements for factor IX replacement therapy.
Dosage Instructions
Your doctor will decide how much Alprolix you use based on your individual need for replacement factor IX therapy. Your doctor may change the dose during your treatment. Alprolix comes as a sterile powder that needs to be mixed with the provided diluent before use. It's important not to shake Alprolix when mixing as this can damage the medicine. Mix only when ready to use. If mixed and interrupted, you can keep the mixed product for a maximum of 6 hours when stored at room temperature (below 30°C).
What If You Miss a Dose?
Use your dose of Alprolix as soon as you remember and resume your normal dosing schedule. Do not take a double dose to make up for the missed dose as this may increase the chance of unwanted side effects.
Important: Never double dose to make up for a missed dose. This may increase the chance of getting unwanted side effects.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Headache
- Tingling or numbness in your mouth (paraesthesia)
- Breath odour
- Fatigue
- Dizziness
- Taste disturbance or loss of taste (dysgeusia)
- Pain or redness at site of infusion
- Low blood pressure (symptoms include dizziness or feeling lightheaded)
- Fast or irregular heartbeats (palpitations)
- Pain in your side with blood in your urine (obstructive uropathy)
Seek immediate medical attention if you experience:
- Factor IX inhibition causing easily bruising or bleeding
- Allergic reaction with shortness of breath, wheezing or difficulty breathing
- Chest pain or discomfort
- Swelling of the face, lips, tongue or other parts of the body
- Rash or hives
Important Warnings
There are important safety considerations to discuss with your doctor before using Alprolix.
Who Should Not Take Alprolix
Do not use Alprolix if you are allergic to eftrenonacog alfa or other factor IX replacement factors, or any of the ingredients listed in the medication guide.
Medical Conditions to Discuss
Talk to your doctor if you have any other medical conditions or use any other medicines. Your body can make antibodies called 'inhibitors' against Alprolix, which may stop it from working properly. Alprolix may increase the risk of formation of abnormal blood clots in your body if you have risk factors for developing blood clots.
Pregnancy and Breastfeeding
Check with your doctor if you are pregnant or intend to become pregnant. There is no information on the use of Alprolix during pregnancy. Talk to your doctor if you are breastfeeding or intend to breastfeed. It is not known whether Alprolix passes into breast milk. Your doctor will discuss the risks and benefits in both situations.
Drug Interactions
It's important to tell your doctor about all medications you're taking to avoid potential interactions.
- Any medicines you get without a prescription from pharmacy, supermarket, or health food shop
- Vitamins or supplements
- Any medicines for other conditions
Alcohol & Driving
Be careful with activities that require alertness until you know how Alprolix affects you.
Alcohol
No specific alcohol warnings mentioned in the source material.
Driving and Operating Machinery
Be careful before you drive or use any machines or tools until you know how Alprolix affects you.
Storage
Keep Alprolix in the pack until it's time to use it. This medicine should be protected from light. Store in the refrigerator at 2°C to 8°C. Do not freeze. If necessary, you can keep Alprolix out of the refrigerator for a single 6-month period, storing the sealed carton in a cool dry place where temperature stays below 30°C. Record the date when removed from refrigerator on the carton. Once reconstituted, keep at room temperature (below 30°C) for up to 6 hours and protect from direct sunlight.
Overdose Information
If you think you have used too much Alprolix, you may need urgent medical attention. Immediately contact your doctor, go to the Emergency Department at your nearest hospital, or phone the Poisons Information Centre (13 11 26 in Australia or 0800 764 766 in New Zealand). Do this even if there are no signs of discomfort or poisoning.
Frequently Asked Questions
Once you mix the Alprolix powder with the diluent, you can keep it at room temperature (below 30°C) for up to 6 hours. Make sure to protect it from direct sunlight.
Tell your doctor immediately if bleeding is not controlled after using Alprolix. This is important information your doctor needs to know right away.
Yes, if necessary, you can keep Alprolix out of the refrigerator for a single 6-month period. Store the sealed carton in a cool dry place where temperature stays below 30°C and record the removal date on the carton.
Use your dose as soon as you remember and resume your normal dosing schedule. Never take a double dose to make up for the missed dose as this may increase the chance of unwanted side effects.
Mix the Alprolix powder with the provided diluent only when you're ready to use it. It's important not to shake the medicine when mixing as this can damage it. Always inspect the solution before use – it should be clear to slightly opalescent and colorless.
Tell any other doctors, dentists, and pharmacists who treat you that you are using Alprolix. Also inform your doctor if you're about to have any blood tests.
No, never give your medicine to anyone else, even if they appear to have the same condition as you. Alprolix is for single use in one patient only.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.