Aldurazyme (Laronidase)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Aldurazyme Used For?
Aldurazyme is an enzyme replacement therapy used to treat Mucopolysaccharidosis I (MPS I), a condition where the body lacks sufficient levels of the enzyme α-L-iduronidase.
Primary Uses
Aldurazyme is primarily used to restore enzyme activity in patients with MPS I, helping to reduce the accumulation of glycosaminoglycans (GAGs) in the body.
How It Works
Aldurazyme provides the missing enzyme α-L-iduronidase, which helps break down GAGs, preventing their harmful buildup in tissues.
Good to know: Aldurazyme is not addictive.
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How to Take Aldurazyme
Aldurazyme is administered by a healthcare professional through an intravenous infusion.
Dosage Instructions
The recommended dosage of Aldurazyme is 100 U/kg (0.58 mg/kg) of body weight, given once a week.
What If You Miss a Dose?
It's important to keep your infusion appointments. If you miss a dose, contact your healthcare provider to reschedule.
Important: Do not double the dose if you miss an appointment.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- infusion-associated reactions (flushing, redness, itchiness, tenderness, pain, warmth, burning, stinging, swelling)
- headaches
- chest pain
- stomach ache
- muscle tenderness or weakness
Seek immediate medical attention if you experience:
- allergic reactions (rash, itching, hives)
- swelling of the face, lips, or tongue
- shortness of breath or wheezing
- respiratory failure
Important Warnings
There are important considerations to keep in mind before using Aldurazyme.
Who Should Not Take Aldurazyme
Do not use Aldurazyme if you have had severe allergic reactions to laronidase or any of its ingredients.
Medical Conditions to Discuss
Inform your doctor if you have breathing problems or are taking other medications, especially if you have a child under 5 years prescribed Aldurazyme.
Pregnancy and Breastfeeding
Consult your doctor if you are pregnant or breastfeeding, as the effects of Aldurazyme during these periods are not well-studied.
Drug Interactions
Certain medications may interact with Aldurazyme and affect its efficacy.
- chloroquine
- procaine
Alcohol & Driving
Be cautious with alcohol consumption and operating machinery while taking Aldurazyme.
Alcohol
Inform your doctor if you consume alcohol.
Driving and Operating Machinery
Exercise caution when driving or using machinery until you know how Aldurazyme affects you.
Storage
Aldurazyme is stored in a hospital or clinic pharmacy.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Symptoms may include nausea, abdominal pain, headache, dizziness, and difficulty breathing.
Frequently Asked Questions
The time it takes for Aldurazyme to show effects can vary by individual, as it is part of a long-term treatment plan.
There are no specific dietary restrictions mentioned for Aldurazyme.
No, Aldurazyme is not considered addictive.
Consult your doctor before stopping Aldurazyme, as it is part of a treatment regimen for MPS I.
You should inform your doctor if you consume alcohol while on Aldurazyme.
There is no information provided about weight gain associated with Aldurazyme.
Consult your doctor regarding the safety of Aldurazyme for elderly patients, especially those with pre-existing conditions.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.