Revestive (Teduglutide)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Revestive Used For?
Revestive contains teduglutide and is specifically designed to help people with Short Bowel Syndrome who need extra nutrition or fluids through IV feeding.
Primary Uses
Revestive is used to treat adults and children 2 years of age and above with Short Bowel Syndrome who need additional nutrition or fluids from intravenous feeding (parenteral support). Short Bowel Syndrome is a disorder that prevents your body from absorbing food nutrients and fluid properly from your gut, often caused by surgical removal of all or part of the small intestine.
How It Works
Revestive improves the absorption of nutrients and fluid from your remaining gut, helping reduce your dependence on IV nutrition support.
How to Take Revestive
Revestive is given as a daily injection under the skin. Your doctor will calculate the exact dose based on your body weight and provide detailed training on how to prepare and inject the medication.
Dosage Instructions
The recommended daily dose is 0.05 mg per kg body weight once per day, given under the skin. Your doctor will prescribe the dose as mL of solution based on your body weight. The injection can be self-administered or given by another person like your doctor, caregiver, or home nurse. If you’re self-injecting, you must receive proper training from your doctor or nurse. Inject at the same time each day, rotating injection sites on your belly or thigh to avoid discomfort.
What If You Miss a Dose?
If you miss your dose at the usual time, take it as soon as possible on that same day. Never use more than one injection in the same day. Do not inject a double dose to make up for the missed dose.
Important: Never inject more than one dose per day, even if you missed your regular dose
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Cold or flu-like symptoms
- Decreased appetite
- Headache
- Stomach pain
- Bloated stomach
- Flatulence
- Nausea
- Vomiting
- Swelling of stoma
- Trouble sleeping
- Cough
- Urinary tract infection
- Reddening, pain or swelling at injection site
Seek immediate medical attention if you experience:
- Swelling of hands and/or feet
- Infection of sinuses, throat, airways or lungs
- Chest pain
- Tiredness, shortness of breath, with or without swelling of ankles or legs (congestive heart failure)
- Allergic reaction with rash, sharp drop in blood pressure, difficulty breathing, hives/itching
- Severe stomach ache with fever (inflammation of pancreas)
- Severe stomach ache, vomiting, constipation (bowel blockage)
- Yellowing of skin and whites of eyes, itching, dark urine, light-colored stools, upper stomach pain (gallbladder problems)
- Blood in stool (could indicate polyps)
- Fainting
Important Warnings
There are several important conditions and situations where Revestive should not be used or requires special monitoring.
Who Should Not Take Revestive
Do not use Revestive if you are allergic to teduglutide or any ingredients in the medication, have or are suspected to have cancer, or have had cancer in the gastrointestinal tract (including liver, gallbladder, bile ducts, and pancreas) within the last five years. Children under 2 years of age or weighing less than 10 kg should not use this medication.
Medical Conditions to Discuss
Tell your doctor if you have severely decreased liver function, certain heart and blood vessel diseases like high blood pressure or weak heart, decreased kidney function, or other severe diseases that are not well controlled. Regular medical monitoring is required, including colonoscopies to check for polyps.
Pregnancy and Breastfeeding
Check with your doctor if you are pregnant, intend to become pregnant, are breastfeeding, or intend to breastfeed. If you become pregnant while using this medicine, tell your doctor immediately.
Cancer Screening Required: Regular colonoscopies are required before starting treatment and during therapy to monitor for polyps and cancer
Drug Interactions
Revestive may affect how other medicines are absorbed from your gut and how well they work.
- May affect absorption of other oral medications
- Doctor may need to adjust doses of other medicines
Alcohol & Driving
Be careful when driving or operating machinery until you know how Revestive affects you.
Alcohol
No specific alcohol interactions mentioned in the source material.
Driving and Operating Machinery
Revestive may cause dizziness in some people. Be careful before you drive or use any machines or tools until you know how Revestive affects you. If you experience dizziness, do not drive or use machines until you feel better.
Storage
Store Revestive in a cool dry place where the temperature stays below 25°C. Do not freeze it. After mixing the powder with solvent, the solution should be used immediately, though it can be stored for up to 3 hours at 25°C. Do not store in the bathroom, near a sink, in the car, or on window sills. Keep away from children and dispose of expired medication at any pharmacy.
Overdose Information
If you think you have used too much Revestive, you may need urgent medical attention. Immediately phone the Poisons Information Centre (13 11 26 in Australia; 0800 POISON or 0800 764766 in New Zealand), contact your doctor, or go to the Emergency Department at your nearest hospital. Do this even if there are no signs of discomfort or poisoning.
Frequently Asked Questions
The source material does not specify how long Revestive takes to show effects. Your doctor will monitor your progress through regular appointments to assess how well the medication is working for you.
The source material does not mention any food restrictions with Revestive. Since it’s an injection given under the skin, food timing should not affect the medication.
If you miss your dose at the usual time, take it as soon as possible on that same day. Never use more than one injection in the same day, and do not inject a double dose to make up for the missed dose.
Rotate injection sites each day using the upper, lower, left and right sides of your belly to avoid discomfort. You can also use your thigh if you have pain or tissue hardening on your belly. Avoid areas that are inflamed, swollen, scarred, or near a stoma.
Regular colonoscopies are required to check for polyps (small abnormal growths) in your colon and rectum. Adults need these examinations once a year during the first two years, then at minimum five-year intervals. Children need them after 1 year of treatment and every 5 years thereafter.
Do not stop using Revestive or lower the dosage without checking with your doctor. If you stop using it suddenly, your fluid balance may change, which could be harmful.
Do not use Revestive if you notice that the solution is cloudy or contains particles. The final solution should be clear. If it’s cloudy or has particles, discard it and start preparation again with a new vial.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.